Introduction. One of the key indicators of the effectiveness of occupational health risk management measures is occupational morbidity. The Sverdlovsk region is characterized by a significant percentage of workers who are exposed to occupational hazards, which determines the need for a systematic analysis of the dynamics and structure of occupational pathology.

The study aims to analyze the dynamics, structure, and regional characteristics of newly identified and accumulated occupational morbidity in the Sverdlovsk Region over the period 2011–2025.

Materials and methods. In the course of the work, the authors studied the data contained in the registry of patients in the Sverdlovsk region with established occupational diseases (3806 cases in 2968 people), as well as information about patients with occupational diseases registered in medical organizations in the region (6855 cases in 6121 people). The continuous observation method was used to analyze occupational morbidity, and therefore representativeness errors were not calculated.

Results. Despite the consistently high proportion of workers who are adversely affected by work, the rate of newly diagnosed occupational pathology in the region has decreased by 7.8 times in 15 years (from 4.39 to 0.56 per 10,000 employees). During this period, the structure of occupational morbidity underwent drastic changes: the proportion of pathology caused by physical factors increased from 6.9% to 54.9%, while the proportion of diseases associated with chemical factors decreased from 82.9% to 32.9%.

Limitations. The study is limited to the time frame 2011–2025.

Conclusion. Priority areas for the prevention of occupational morbidity in the Sverdlovsk region should be considered: reducing the effects of physical and chemical factors, the severity of the labor process, as well as improving the system for early detection of occupational diseases associated with them at the stage of periodic medical examinations.

Ethics. The conclusion of the local Ethics Committee is not required for conducting the study.

Contributions:
Gazimova V.G. — concept and design of the research, writing and editing of the text, approval of the final version of the article, responsibility for the integrity of all parts of the article;
Shastin A.S. — writing and editing of the text, approval of the final version of the article, responsibility for the integrity of all parts of the article;
Sozonova T.V. — data collection, statistical data processing, approval of the final version of the article, responsibility for the integrity of all parts of the article;
Fedoruk A.A. — text editing, approval of the final version of the article, responsibility for the integrity of all parts of the article;
Martin S.V. — text editing, approval of the final version of the article, responsibility for the integrity of all parts of the article;
Ivashchenko M.A. — text editing, approval of the final version of the article, responsibility for the integrity of all parts of the article.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 08.05.2026 / Accepted: 15.05.2026 / Published: 27.06.2026

Introduction. Underground coal mining is one of the types of economic activity with the largest proportion of workers engaged in harmful and dangerous working conditions, characterized by the complex effects of harmful factors of the production environment and the labor process.

The study aims to assess the impact of harmful production factors during underground coal mining on the development of chronic general somatic diseases in workers in order to develop adequate preventive measures aimed at maintaining health and prolonging working longevity.

Materials and methods. The authors conducted a cross-sectional epidemiological study, during which they examined the prevalence of chronic general somatic diseases. The object of the study was workers engaged in underground coal mining in a coal mine, the main group (272 people). The comparison group included repair and technical personnel employed in open-pit coal mining (140 people).

Results. It was found that the prevalence of chronic general somatic diseases among workers engaged in underground coal mining and workers in the comparison group are at the same level and amount to 78.0±2.5 and 70.7±3.8 per 100 employees, respectively, and significantly (p<0.05) increase with increasing length of service. The prevalence of diseases associated with metabolic disorders of lipoproteins and other lipidemias is significantly (p<0.05) higher among workers engaged in underground coal mining, and is 44.5±3.0, compared with the comparison group of 12.9±2.8. Among workers engaged in underground coal mining, a significant (p<0.05) increase in indicators was recorded with increasing length of service work from 34.9±4.2 with experience up to 15 years to 52.7±4.1 with experience of 15 years or more. It is shown that the prevalence of circulatory system diseases among workers over 40 years of age varies significantly — in the comparison group, the indicator was 40.7±5.5 per 100 employees, which is significantly higher (p<0.05) compared with workers engaged in underground coal mining — 20.0±3.1. It was found that dorsopathies are significantly (p<0.05) more often registered among workers engaged in underground coal mining, and amount to 33.1±2.9 per 100 workers, with 23.6±3.6 per 100 workers in the comparison group.

Limitations. The study is limited to a sample of surveyed employees of two coal mining enterprises using underground and open-pit coal mining methods (a coal mine and a coal mine).

Conclusion. It is shown that workers engaged in underground coal mining have an earlier formation of chronic dorsopathies. Lower prevalence rates of circulatory system diseases have been established in the group of workers engaged in underground coal mining compared to the group of workers engaged in open-pit coal mining, which may be due to the effect of a healthy worker, which is manifested as a result of the selection of people without chronic diseases characterized by high blood pressure in the profession of underground coal mining. In the first place in the structure of the prevalence of general somatic diseases in both groups were diseases of the endocrine system, eating disorders and metabolic disorders. Conducting a cross-sectional epidemiological study of the prevalence of chronic noncommunicable diseases based on data from periodic medical examinations of employees provides an opportunity to identify production-related forms of diseases in the structure of general somatic pathology. The results of such studies can be used in the development of scientifically based medical and preventive measures.

Ethics. The study was conducted in accordance with the Helsinki Declaration and approved by the Local Ethics Committee of the Izmerov Research Institute of Occupational Health, Protocol No. 5 dated 08/02/2023.

Contributions:
Varakuta I.S. — research concept, data collection, text writing, editing;
Leskina L.M. — research concept and design, editing, responsibility for the integrity of all parts of the article, writing the text;
Golovkova N.P. — research concept and design, editing, responsibility for the integrity of all parts of the article, writing the text;
Lyubimova M.S. — research concept, text writing, editing;
Khvalyuk P.O. — research concept, text writing, editing;
Lezhnev E.A. — research concept and design, data collection;
Chasovskikh E.V. — research concept and design, data collection.

Funding. The study was conducted within the framework of research work No. FGFE-2023-0014.

Conflict of interest. The authors declare no conflict of interest.

Received: 04.05.2026 / Accepted: 18.05.2026 / Published: 00.00.2026

Introduction. The professional activity of diagnostic physicians in computed tomography (CT) and magnetic resonance imaging (MRI) departments is characterized by chronic exposure to static, sensory, and psychoemotional loads, which creates a high risk of developing musculoskeletal disorders, visual fatigue, and burnout syndrome.

The study aims to evaluate the clinical, psychophysiological, and economic efficiency of a developed organizational-preventive work model based on the integration of regulated breaks with therapeutic exercise elements into the work process of CT and MRI diagnostic physicians.

Materials and methods. A prospective controlled before-and-after study included 52 diagnostic physicians from CT and MRI departments of two multidisciplinary hospitals (mean age 39.2±6.8 years; work experience 11.4±6.1 years). The researchers have introduced mandatory 10-minute organizational and technological breaks at the workplace every 1.5 hours with a set of therapeutic exercises for the cervical spine and gymnastics for the eyes. The follow-up period was 12 months. Assessment included questionnaires (Visual Analogue Scale — VAS, Modified Fatigue Symptom Inventory — MFSI-SM, Pittsburgh Sleep Quality Index — PSQI-R), psychophysiological testing (computer test "Number-Letter Combinations"), analysis of production indicators (equipment load, timing, error rate), and correlation analysis.

Results. After 12 months of implementing the model, the researchers have recorded a significant decrease in pain intensity: in the neck/shoulders — from 6.1±1.7 to 3.2±1.3 points according to VAS (≈47.5%; p<0.001), in the lower back — from 5.9±1.9 to 3.3±1.4 points (≈44.1%; p<0.001). The severity of asthenia on the MFSI-SM scale decreased by 43.5% (p<0.001), the global PSQI sleep quality index improved by 34.5% (p<0.001). The attention efficiency coefficient (Ke) increased by 25.3% (p<0.001). A moderate inverse correlation was found between the reduction of neck pain and the increase in Ke (r=–0.49; p=0.002). Production indicators: average daily equipment load increased by 17.3% (from 9.8±1.1 to 11.5±1.3 examinations per day; p<0.001), the average time for reporting one examination decreased by 9.2% (p=0.009), and the number of identified discrepancies in reports decreased by 33.3% (p=0.01).

Limitations. The limited sample size does not provide sufficient statistical power for the unconditional dissemination of conclusions to the entire set of diagnostic specialists. The long period of observation required constant administrative support to ensure compliance with the rules of preventive breaks, which may make it difficult to reproduce the model in conditions of limited human resources.

Conclusion. The developed organizational-preventive model demonstrated high comprehensive efficiency, providing a synergistic effect: a significant improvement in the somatic and psychoemotional health of diagnostic physicians is accompanied by increased labor productivity and diagnostic quality without increasing staff numbers. The model is recommended for implementation in specialized radiology departments.

Ethics. The study was approved by the local Ethics Committee of the Medical Biotechnological University of Innovations and Continuing Education of the State Research Center – Burnasyan Federal Medical Biophysical Center of the Federal Medical Biological Agency of Russia. (Protocol No. 127 dated October 17, 2025). All participants signed informed consent.

Contributions:
Bushmanov A.Y. — concept and design of the study, approval of the final version of the article;
Titova N.A. — collection, instrumental measurements, statistical processing, approval of the final version of the article;
Karimova D.Y. — data analysis and interpretation, text writing, literature review, approval of the final version of the article.

Acknowledgement. The authors thank the clinic staff for their assistance in conducting the research.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 01.04.2026 / Accepted: 15.04.2026 / Published: 27.06.2026

Introduction. Silicosis remains one of the most common forms of pneumoconiosis among occupational lung diseases. However, effective preventive and therapeutic measures aimed at accelerating the removal of dust particles from the respiratory tract remain underdeveloped.

The aim of this study was to evaluate the feasibility of drugs with antioxidant properties available in pharmacies to stimulate lung self-clearance from quartz dust particles in a rat experimental model of silicosis.

Materials and methods. The study was performed in male Wistar rats that received a single intratracheal instillation of a standard quartz dust sample. Experimental groups were treated intraperitoneally with ethylmethylhydroxypyridine succinate (EMHPS) or dimethyloxybutylphosphonyldimethylate (DMOBPDM) for 4 weeks; 0.9% saline was used in the positive and negative control groups. At the end of the experiment, wet and dry lung weight, lung mass coefficient, dry weight index, wet to dry ratio, body weight gain, and the relative amount of quartz dust spontaneously removed from the lungs were determined.

Results. In the fibrotic groups, wet and dry lung weights were significantly higher than in controls, accompanied by a tendency toward reduced body weight gain. The relative amount of spontaneously removed quartz dust was significantly higher in the EMHPS group than in the positive control, whereas DMOBPDM did not increase dust clearance and yielded values did not exceed those in the control.

Conclusions. EMHPS enhances self clearance of quartz dust in experimental silicosis in rats, while DMOBPDM showed no such effect under the studied conditions. The results suggest the potential of systemic antioxidant drugs for the pathogenetic prevention and treatment of dust related lung diseases, including silicosis.

Contributions:
Tonshin A.A. — research concept and design, conducting experiments, collecting and processing experimental data, writing text;
Makarov A.F. — concept and design of research, conducting experiments, preparation of literature data;
Krikunov O.V. — conducting experiments;
Bidevkina M.V. — concept and design of research, conducting experiments, preparation of literature data;
Muravskaya M.P. — conducting experiments;
Nikolaev I.M. — conducting experiments;
Bonitenko E.Yu. — research concept and design, text writing, editing.

Funding. The study was carried out within the Framework of research project No. FGFE-2025-0023 of the state assignment.

Conflict of interest. The authors declare no conflict of interest.

Received: 21.05.2026 / Accepted: 25.05.2026 / Published: 27.06.2026

Preserving the reproductive health of female medical workers is a priority task of occupational medicine and demographic policy. The review analyzes current data from peer-reviewed publications from international (PubMed, MEDLINE, Scopus) and Russian (eLibrary, RSCI) scientific databases on the impact of harmful industrial factors on the reproductive health of female medical workers. Original studies, systematic reviews, and meta-analyses containing quantitative risk assessments were selected: odds ratio (OR), relative risk (RR), and etiological proportion (EP).

The presented analysis convincingly shows a statistically significant association between exposure to harmful occupational factors and reproductive health disorders in medical professionals, including pregnancy complications and decreased fertility.

Contributions:
Fesenko M.A. — research concept and design, data analysis and interpretation; approval of the final version;
Golovaneva G.V. — research concept and design, data analysis and interpretation, editing;
Miteleva T.Y. — collecting and processing material, writing text;
Vujtsik P.A. — collecting material, writing the text of the article section;
Khalturina Yu.V. — collecting material, writing the text of the article section;
Utkina N.S. — collecting material, writing the text of the article section;
All co-authors — approving the final version of the article and ensuring the integrity of all parts of the article.

Funding. The study had no funding.

Conflict of interests. The authors declare no conflict of interest.

Received: 01.04.2026 / Accepted: 28.05.2026 / Published: 00.00.2026

The syndrome of professional burnout among medical workers, caused by exposure to non-industrial and a complex of harmful production factors and factors of the labor process (high tension, biological, chemical, physical factors), has acquired the character of an epidemic, threatening both the health of workers and the safety of patients. This syndrome is considered as prolonged occupational stress, which is realized in the disruption of adaptation to chronic exposure to high neuropsychiatric stress. The pathogenesis is based on functional overstrain of the nervous system, which is caused by psychoemotional stress in conditions of high intensity of the labor process (class 3.2–3.3). Traditional models that explain burnout solely by factors of the work environment cannot fully explain the individual variability of stress tolerance.

This review systematizes current data on the genetic and epigenetic determinants of variability within the framework of the biopsychosocial model and the concept of "differential susceptibility."

The results of the literature analysis demonstrate that the individual vulnerability profile to burnout is formed by polymorphisms in genes regulating key neurobiological systems: dopaminergic (COMT, DRD2, DRD4, SLC6A3 genes), serotonergic (SLC6A4, HTR1A, HTR2A), neuroplasticity (BDNF) and circadian rhythms (PER3). The authors paid special attention to the polymorphisms Val158Met of the COMT gene and Val66Met of the BDNF gene, which acted as markers of plasticity under chronic stress, mediating both vulnerability and resistance. Epigenetic mechanisms (DNA methylation of the SLC6A4, NR3C1, and DRD2 genes, changes in microRNA expression, and reactivation of endogenous retroviruses) are a dynamic link linking chronic occupational stress with molecular and cellular changes.

The analysis reveals the methodological limitations of existing studies, including the predominance of the "candidate genes" approach and the lack of studies performed using the genome-wide association search method. The prospects for overcoming the problem lie in the field of personalized occupational health: the use of genetic data to optimize work schedules, targeted prevention among risk groups, and the introduction of predictive biomonitoring based on epigenetic markers. For clinical validation, a transition to large-scale longitudinal studies is necessary.

Contributions:
Zaidullin I.I. — concept and design of the study, writing the text;
Valeeva E.T. — writing, editing;
Masyagutova L.M. — writing text, editing;
Gizatullina A.R. — collection and processing of material, statistical data processing.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 05.05.2026 / Accepted: 15.05.2026 / Published: 27.06.2026

Polymorphisms in the genes encoding the first-line antioxidant defense enzymes (SOD2, CAT, GPX4) may reduce their activity and lead to the accumulation of free radicals, which may increase the risk of cardiovascular diseases when exposed to xenobiotics. In this regard, it is necessary to study informative molecular genetic markers related to antioxidant protection.

The study aims to find an association of a combination of functional polymorphisms rs4880 (SOD2), rs1001179 and rs7943316 (CAT), rs713041 (GPX4) with diseases characterized by high blood pressure in converter shop workers.

The sample included 151 employees of the converter shop (the main group) and 203 employees of administrative and management departments (the comparison group). The authors have collected information on diseases I10–I15 (ICD-10), as well as whole blood sampling. The researchers have used commercial kits and an Applied Biosystems QuantStudio 3 amplifier for genotyping. The dominant genetic model of inheritance and alleles were used to determine the odds ratio.

The analysis of gene polymorphism combinations revealed that carriage of at least one of the polymorphic alleles (p=0.034) and genotypes (p=0.036) of SOD2 (rs4880) and CAT (rs1001179) significantly increased the risk of hypertensive diseases in the converter shop workers, but not in the controls.

Identification of polymorphisms of genes of the first line of antioxidant protection can increase the effectiveness of identifying risk groups for the occurrence and development of diseases characterized by high blood pressure among workers of the converter shop.

Limitations. The study did not take into account the influence of electromagnetic radiation from office equipment, as well as the lifestyle of patients.

Ethics. The ethical approval of the study was received from the local Ethics Committee of the Federal Budgetary Institution of Science "Yekaterinburg Medical Scientific Center for Prevention and Health Protection of Industrial Workers" of Rospotrebnadzor (Protocol No. 1 dated 02/26/2021). The work was carried out in accordance with the ethical standards of the Helsinki Declaration of the World Medical Association (2013 edition).

Contributions:
Bereza I.A. — research concept and design, data collection and processing, text writing;
Kikot A.M. — research concept and design, data collection and processing, text writing;
Shaikhova D.R. — research concept and design, data collection and processing, text writing;
Sutunkova M.P. — research concept and design, editing;
Polianina D.D. — data collection and processing, editing;
Bokovoy V.D. — data collection and processing, editing;
All co-authors— approving the final version of the article and ensuring the integrity of all parts of the article.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 13.05.2026 / Accepted: 21.05.2026 / Published: 27.06.2026