Study covered cardiovascular system state in 79 individuals aged 30-40 and living in populated area influenced by aluminium industry enterprise, and in reference group of 29 individuals of similar age, residents of recreation territory. All the examinees had no previous cardiovascular diseases. Findings are that in the area influenced by aluminium industry enterprise, environmental objects (ambient air, drinkable water) pollution with specific chemicals exceeds existing hygienic norms 1,2-40-fold. In conditions of chronic complex combined exposure to priority pollutants, levels of aluminium and fluoride iod in biologic media (urine) of the population 3.,0 times exceeds analogous parameters in the reference group, and 3-4 times higher than the reference values. Over 65% of the examined population in the area influenced by aluminium industry demonstrate cardiovascular diseases even at the age of 35-40 years, that in one third of cases are associated with disordered endothelial functions and prevalent hypersympaticotonic type of vegetative regulation - that are reliably associated with increased levels of aluminium and fluoride iod in the body.

Evaluation of occupational health risk for workers engaged into potassium ores extraction enterprise covered following data: quantitative, semi-quantitative and qualitative assessment. Qualitative risk assessment was based on hygienic criteria: deviation of occupational environment and working process parameters from hygienic norms, with occupational risk category establishment. The results obtained helped to classify the workers' occupational risk from moderate to high (intolerable). Semi-quantitative risk assessment included determination of one-digit index of occupational disease (bilateral neurosensory deafness) - this level equalled 0.25 for machine operators. The assessed value of one-digit index of occupational disease corresponds to high (intolerable) risk and matches the risk level revealed in qualitative assessment. Qualitative assessment covered workers' health risk associated with occupational diseases and diseases related to work. The obtained occupational risk values are higher than acceptable one for occupational groups. Occupational risk levels obtained in various assessments are compared via categorizing scale.

The authors evaluated influence of exposure to occupational environment and working process factors on state of endothelium-dependent arterial tone regulation in blowing-out operators of thermal pit oil extraction. Pre- and past-shift examination covered 31 operators including 18 ones with 1 to 6 years of service and 13 ones with length of service over 12 years. In blowing-out zone, the operator appears to be exposed to combined influence of convection heat and oil components. Environmental heat load index in operators' workplace equals 27.5-29.2 and corresponds to 3,4-4 class (dangerous) of work conditions. Concentration of oil components including benzene, toluene, ortho-, metha-, para-xylene corresponds to 3,1-3,2 class of work conditions. The operators' serum demonstrates high levels of benzene, ortho-, metha-, para-xylene, toluene - those levels correlate with length of service. Among aromatic hydrocarbon recipients, “slow” and «fast inactivators» are seen. This phenomenon could be connected with depleted enzyme pool and substrate inhibition of xenobiotics biotransformation development in some recipients. First signs of endothelial dysfunction in blowing-out operators are seen for length of service under 6 years only after working shift and are reversible in 18 hours. For length of service over 12 years, stable morphofunctional endothelial dysfunction in brachial artery is developed. Statistic analysis revealed correlation relationships between aromatic hydrocarbons in blowing-out operators' serum, changes in morphofunctional signs of endothelial dysfunction and disordered regulation of brachial artery tone.

Work conditions of main occupations in fluorine polymers production (machine operators, boilersmiths, electric gas welders) are characterized by combine exposure to chemical and physical occupational factors: difluorochloromethane, 1,2-dichloroethane, chlorophormium, fluorodichloromethane, occupational noise, general vibration. At workplaces, equivalent noise levels exceed MACs up to 22 dBA; work conditions are assigned to hazardous (class 3.1-3.3) and cause a priori occupational risk from low to high. With increased length of service from 6 years and more, the workers' serum demonstrates increased chlorophormium level up to 2.3 times, that of 1,2-dichloroethane - up to 7.0 times vs. the parameters of workers with length of service under 6 years, and deviated hematologic and biochemic parameters characterizing RBC depression, depleted phagocytosis. Reliable connection is between increased activity of gamma-GT, lower general antioxidant activity and chlorophormium content of blood. For length of service at 6-10 years, gamma-GT level increased (72.79% - very high degree of occupational relation). For length of service over 10 years, homocystein level is increased with very high (76.53%) and nearly complete (80.41%) degree of relation to work conditions, increased lymphocytes with average (49.50%) degree of relation. These parameters should be considered in early diagnosis of diseases and specification of preventive measures in fluorine polymers production workers.

The article presents results of analysis concerning mortality among able-bodied population in RF subjects, dependent on economic development level, exemplified by Privolzhsky Federal District regions in 2015. Notion is that mortality level among able-bodied population has no linear dependence on economic development level. Only one cluster including Tatarstan Republic (the most economically developed region of Privolzhsky Federal District) demonstrates considerably low mortality level - 476.7 cases per 100,000 people in the region. Industrially developed regions of 2^nd cluster, the mortality level is considerably higher than the average in Privolzhsky Federal District. For 3^rd cluster, multidirectional trends are characteristic. Moreover, significant differentiation of economic development of the territories leads to considerably distorted results of econimc evaluation of losses caused by mortality (losses of GDP according to Methodology of calculating econimic losses from mortality, morbidity and disablement of population) - that causes underestimation of losses in 1^st cluster and significant overestimation in 3^rd cluster.

Examination covered workers of enterprise producing phthalic anhydride and fumaric acid (n = 104). Phthalic acid was detected in serum of main group workers (phthalic and fumaric acids in air of workplace) and in 100% of the examinees in concentrations range 0.077-0.420 mg/dm³, in reference group workers (absence of occupational hazard) - in 71% of the examinees in concentrations range 0.005-0.154 mg/dm³. Fumaric acid in serum of reference group workers was seen in 57% of the examinees in concentrations range 0.001-0.344 mg/dm³, in the reference group - in 26% of the examinees in concentrations range 0.002-0.104 mg/dm³. Average group concentrations (p < 0.05) of phthalic and fumaric acids in serum of main group workers were 2.6 and 7.6 times higher respectively. Reliable decrease of CD95 receptors of T-cells expression was also revealed. Allergic sorbent testing demonstrated increase in specific sensibilization to phthalic anhydride and its derivative phthalic acid in 79.2% of the workers, maximal average group concentrations of IgE to phthalic anhydride were detected in serum of mechanical technicians and operators of crystallization, absorption and chemical reagents preparation. Mathematic model of logistic regression describing dependence “serum level of phthalic acid - specific IgE to phthalic anhydride level” (exposure - response probability) obtained parameters - b₀ = 0.038; b₁ = 4.064; R² = 0.18; F = 19.568; p<0.01, that prove reliability of the model established. Immune regulation parameters: CD95+, TNFR, pro-apoptotic factor bax, anti-apoptotic protein Bcl-2, IgE specific to phthalic anhydride - describe immune regulation in workers of phthalic anhydride production and can be recommended as effect markers in evaluation of health risk for workers exposed to organic synthesis products.

The authors studied parameters of transitory disablement morbidity in all workers of Perm' region of Sverdlovsk railway service, including locomotive crew workers, over 2010-2016. Prognosis of transitory disablement morbidity was determined for 2017. Findings are that incidence parameters in locomotive crew workers always exceeded those in all workers, and average duration of one disablement case in them always was less (p<0.05). If incidence parameter in 2016, when compared to 2010, both in all workers and locomotive crews increased significantly (by 17.8 and 20.0% respectively, p<0.05), then duration parameter changed insignificantly (by 2.4 and 0.7% respectively, p>0.05). With that, average disablement duration increased by 10.1% in all workers and by 6.7% in locomotive crew workers (p<0.05). Main contribution into morbidity parameters both in all workers and in locomotive crew members is made by respiratory diseases, locomotory system diseases, traumatism and poisonings, circulatory disorders, digestive tract diseases. The authors found a stable trend to increase of transitory disablement morbidity both by incidence and by duration in all workers and locomotive crew workers.

The article presents results of complex studies concerning dust discharges by enterprise extracting and processing potassium salts, and describes components, dispersion contents and forms of solid particles. Summary balance set profile of dust discharges by enterprise and determined priority chemicals for certain production. Results of studies concerning ambient air quality at borderline of sanitary protective zone of the enterprise are demonstrated, and list of chemical elements is determined. Comparative analysis covered dust particles forms on borderline between sanitary protective zone and industrial discharges sources. The results obtained helped to conclude incorrect occupational control of suspended particles, performed by the enterprise. Construction of actual industrial discharge profile is necessary stage to justify a program controlling solid dust discharged by the enterprise.

Immunologic and genetic examination covered workers of halogen hydrocarbons production. Findings are immune regulation changes characterized by lower phagocyte activity, increased production of serum immune globulines IgG and intracellular immune mediators interleukin-4 and interleukin-6, if compared with reference group parameters, exceeded reference interval in level of specific IgG to chlorophormium. Immune features revealed were associated with increased frequency of minor pathologic genotype in TLR4, ZMPSTE24 and eNOS genes, and with higher frequency of mutant allel CYP1A1, IL-17F and VEGFA in the main group due to prevalence of heterozygous genotype variant. The obtained data on features of immune regulation and genetic variability in workers engaged into halogen organic compounds production demonstrate detoxification disorders, endothelial dysfunction, immune cytokine dysregulation and specific sensibilization.

Materials of Russian monitoring of economic state and public health by RLMS-HSE over 2016 helped to study relationships of three groups of microsocial risk factors (social demographic factors, social capital and social state) and objective and subjective health parameters in workers of Russia (select of 7943 people). Findings are that microsocial factors have stronger influence on self-esteem of health, than on its objective characteristics. Sensitivity to microsocial factors action appeared to be different in various sex- and age-matched groups. If concerning some parameters (specifically, fear to lose the job and health self-esteem), the relationship appeared to be bidirectional. Evidence was that presence of children and their quantity can be a health risk factor in some age groups - that can be explained by limited social resources and weak social capital.

The authors analysed transitory disablement morbidity among working population in Perm' region and 47 municipal districs within the region. Findings are that main disablement causes are respiratory diseases, locomotory disorders, traumatism, poisonings and some other consequences of external influences. Factor and multiple regression analysis helped to describe relationship between integral social economic factors and transitory disablement morbidity. Evidence is that level of social and economic well-being, social security level are priority macrosocial risk factors influencing workers' health. The authors calculated relative and absolute health losses associated with macrosocial factors action, revealed «risk territories» that require urgent measures to lower influence of macrosocial risk factors on workers' health.