The article covers major principles of activities performed by Kazakhstan Republic Committee on Consumers Rights Protection, its objectives, functions to achieve sanitary and epidemiologic well-being of the population.

To study influence of chrysotile-asbestos dust on health of asbestos production workers, the authors conducted biochemical study of serum lipids peroxidation in workers of mining transport enterprise and ore-dressing complex, in accordance with length of service. According to comparative analysis of the resuts obtained, the workers of mining transport enterprise and ore-dressing complex demonstrate more active lipid peroxidation with longer length of service, more pronounced in ore-dressing complex workers.

Studies of allowable (safe) length of service in occuptions of mining transport enterprise «Kostanaiskie mineral» JSC were conducted to forecast occurrence of dust lung diseases in workers exposed to chrysotile-asbestos dust. To calculate allowable length of service, the authors used values of average shift concentration of chrysotile-asbestos dust. Based on the calculated data of the allowable length of service in chrysotile-asbestos production, the authors forecasted course of dust lung diseases.

The article demonstrates that patients with chronic obstructive lung disease (COLD) of both mixed and bronchitis forms with medium severity grade appeared to have 2 types of changes in morphologic types of serum faces. Patients with various clinical forms of severe COLD presented unidirectional change in morphologic types of serum faces. Patients with various forms of moderate COLD had one variant of morphologic types of serum faces was close to that in the patients with more severe clinical course - so that face can be considered as a «transitional form» between moderate and severe COLD. These results are interesting in specifying diagnostic criteria of COLD severity and additional diagnostic criteria of the severity grade.

Buccal epithelium cytograms were analyzed in workers of chrysotile-asbestos production «Kostanaiskiye mineraly» JSC. Findings are that 10-20 years of service are associated with increased number of 4th differentiation grade cells and correspondingly decreased number of 5th differentiation grade cells. Later, with 20 years of service, numbers of 4th and 5 th grade epitheliocytes reach initial values. With 10-20 years of service, integral parameters of differentiation index, cornification index and intracellular relations decrease. Findings are that 10-20 years of service are connected with domination of proliferation over differentiation processes. Length of service over 20 years is with adaptive processess in the workers. These data are important in evaluation of mucosal system in variable length of occupational service.

Cytologic studies covered broncho-alveolar lavage in animals exposed to mechanical rubber aerosol in subacute (2 months) and chronic (5 months) experiments. Under exposure to mechanical rubber aerosol, the experimental animals developed disorders of lung protective mechanisms. Subacute dust inhalation in the experimental animals caused higher counts of neutrophils and degeneratively changed cells with increased functional activity of alveolar macrophages and neutrophils. Chronic dust inhalation in the experimental animals proved lower functional activity alveolar macrophages and neutrophils.

Military service activity appeared to influence health state of military personnel. Body strain at initial stages of the service, connected with stress situation, affects general body resistance and manifests in higher general morbidity level with transitory disablement that decreases with adaptation. Based on normalized intensity parameters, the equation enables to ease a procedure of evaluation and forecast of transitory disablement morbidity in draft military personnel.

The article covers evaluation of work strain in major and auxiliary occupations of by-product coke industry. The study results conclude that occupational activity of by-product coke industry workers, under exposure to occupational hazards, affects the workers' performance. Major occupations workers demonstrate higher level of functional strain of CNS, poor concentration of attention and lower ability to switch over, decreased general performance, vs. the auxiliary occupations workers who demonstrated increased cardiovascular and neuro-muscular strain due to occupational activity.

The authors studied influence of ecologic factors on respiratory diseases development in urban residents of Kazakhstan Republic. Multivariate (correlation and regression) analysis demonstrates that chronic obstructive lung disease development is contributed by high concentration of nitrogen oxide in ambient air (r = - 0.75; p = 0.005) in Temirtau, Kamenogorsk and Aktau cities, high lead content of sedimented dust (r = 0.64; p = 0.02) in Temirtau, Ust-Kamenogorsk and Ekibastuz cities.

The article deals with results of study covering influence of industrial pollution with mercury on its accumulation level in populated area objects and foods. Mercury content was measured in ambient air, snow, water, bed silt and regional foods of vegetable and animal origin - that is a potential health hazard for Central Kazakhstan population. The data obtained prove that high levels of mercury were detected in all the studied objects.

The work was aimed to find new screeding parameters (biomarkers) for evaluation of health state of workers engaged into enterprises with hazardous work conditions, as exemplified by «Maradykovskyi» object of chemical weapons extinction. Analysis of 27 serum cytokines was conducted in donors and the object personnel with various work conditions. Findings are statistically significant increase of serum eotaxin in the personnel of «dirty» zone, who are regularly exposed to toxic agents in individual filter protective means over the working day. For screening detection of health disorders in the object personnel, the authors suggested new complex biomarker - ratio Eotaxin* IFNγ/TNFα that demonstrates 67.9% sensitivity and 87.5% specificity in differentiating the «dirty» zone personnel and other staffers.

The article covers problems of biochemical methods assessing organophosphorus toxic compounds in objects of chemical weapons extinction. The authors present results of works developing new, more specific and selective biochemical methods.