Features of economic and social development of certain territories in Siberian Federal District caused formation of four clasters varying in shares of workers exposed to occupational hazards and in levels of reversible health losses among able-bodied population. Share of workers exposed to hazardous microclimate, gas contamination, vibraion, noise in claster 4 (Kemerovo region) is 1.5-2 times higher than in other clasters. Leading negative factors for workers in Siberian Federal District are: acoustic factor, work hardiness, work intensity, illumination, gas contamination. Occupational diseases structure is associated with the leading factors.

The article shows that despite implementation of healthy work conditons program in electrolysis workshops of Bratsk and Irkutsk aluminium plants, the main occupational hazard is the workers' exposure to complex of chemicals in concentrations exceeding hygienic norms. Among them, the most important hygienically are hydrogen fluoride, fluorides, metallic and fluoric dust, resinous substances. The stated complex of chemicals, if long acting, causes occupational broncho-pulmonary diseases including chronic obstructive lung disease (COLD). COLD decreases psychologic well-being of patients, with negative influence on physical and psychic components. With that, COLD causes disorders of interactions between individual and environment, as well as of primitive behavioral stereotypic psychologic defences in stress situations. The results obtained should be considered in specification of rehabilitation measures complex for occupational COLD patients.

The authors evaluated use of three variants of biofeedback technologies in rehabilitation of patients with occupational diseases caused by chemical and physical factors. First variant included a-stimulating training with music therapy for relaxation techniques development, the second - combination of EEG-a-stimulating and temperature myographic biofeedback with music therapy, the third - only EEG-a-stimulating and temperature myographic biofeedback. Before and after biofeedback technologies use according to conventional methods, patho-psychologic, psychologic and physiologic parameters were examined. Clinical effect was estimated according to scale from no effect to considerable improvement of the patients' state. The studies prove prospective use of biofeedback technologies in occupational therapy for rehabilitation of individuals suffering from exposure to chemical and physical factors. The treatment dynamics can be analyzed objectively by physiologic parameters saved during each session on patient's local computer and sent on servers via Internet - that could serve as continuous rehabilitation.

Patients with occupational diseases due to physical and chemical factors underwent treatment by impulse magnetic stimulation. Magnetic stimulation improved interaction between subcortical stem structures and associative regions of frontal and temporal brain lobes. There was shorter time of afferent excitation wave conduction at cervical spine level, and time necessary for activation of near-field neurons in somatosensory cortex, restored impulse conduction velocity on peripheral nerves, lower levels of emotional strain, anxiety, better psychologic comfort in patients. Neurosensory deafness patients demonstrated better audiometry parameters and acumetric data.

Examination covered 124 workers with occupational exposure to metallic mercury vapors from 9 to 28 years, 18 patients with chronic mercury intoxication without toxic encephalopathy, and 41 ones with chronic mercury intoxication with toxic encephalopathy. Findings are that individuals exposed to mercury demonstrate altered content of biochemical markers of endothelial dysfuction: lower nitrogen oxide level, increased angiotensin II level. The patients with chronic mercury intoxication demonstrated increased serotonin and endothelin-1 levels, lower concentration of sICAM-1, with that individuals having toxic encephalopathy the changes were associated with altered levels of sVCAM and histamine. Thus, indivuduals with toxic encephalopathy and chronic mercury intoxication have same direction of change in endithelial dysfunction parameters that are more marked than in patients without toxic encephalopathy.

The authors present results of studied nanoparticles toxicity of metals - bismuth (Bi) and silver (Ag) incorporated into natural biopolymer arabinogalactan matrix (AG), prospective antimicrobial compounds Bi-AG and Ag-AG respectively. Subacute toxicity was studied via intragastric (Ag-AG) and intraperitoneal (Bi-AG) injection of Ag and Bi during 9 days in dose of 500 mg/kg of body weight. To study biologic response on subcellular level, the authors used immune histochemical method determining activity of proteins-modulators of apoptosis bcl-2 and caspase-3 in white rats brain neurons. In subacute experiment, despite the same matrix - AG, the body response differed in accordance with metals nanoparticles incorporated into the matrix. Injected Ag-AG caused brain cells readines to apoptosis, irreversible structural changes in brain tissues, lower number of normal neurons in sensomotory area and increased expression of proapoptosis protein caspase 3 in them. Action of Bi-AG caused no increase of programmed cell death process and structural disorders of neural tissue. When biologic properties of nanobiocomposites studied, one should estimate bodily response on cellular and subcellular level.

The article presents hygienic evaluation of work conditions of civil aviation aircrafts pilots, state of occupational and general morbidity. Characteristics cover main occupational factors influencing pilots during flight. Findings are that median levels of noise and sound pressure, general vibration, microclimate parameters during flight do not correspond to hygienic norms. Levels of barometric pressure influencing the aircraft crew, chemicals concentrations, illumination levels, electromagnetic fields intensity correspond to hygienic requirements. Work conditions of civil aviation pilots, according to jeopardy and hazardousness, work hardiness and intensity, are assigned to 3^rd class 1-4 degree mostly due to high levels of acting noise and work hardiness.

Twofold examination in 4-5 years interval covered 77 males exposed to mercury at work during 5 and more years. Serum examination included general cholesterol level and its fractions. For every examinee, level of individual exposure load during the work in hazardous conditions was calculated. Multiple nonlinear regression with direct step-by-step inclusion of signs helped to receive an equation expressing relation of variable (forecasting value of atherogeneity index) with predictors: atherogeneity index level and exposure load value at study, estimated age of examinee for forecasted time. The dependence obtained enables to forecast atherogeneity index in 4-5 years for timely preventive and therapeutic measures in workers with long length of service and exposed to mercury.

Examination covered 98 former workers of causticum production, with chronic exposure to mercury vapors, who were divided into 2 groups: first (n=44) - without chronic mercury intoxication diagnosis, second (n=54) - with chronic mercury intoxication diagnosis. Via PCR-PDRF analysis, the authors studied polymorph variants of genes HSPA1A (+190G/C), HSPA1B (+1267A/G) and HSPA1L (+2437T/C), “Ageing diagnosis: biologic age» program helped to assess biologic age and ageing intensity as difference between biologic age and calendar age. Findings are increased frequency of GG-HSPA1B (+1267A/G) genotype in the group with chronic mercury intoxication diagnosis (p=0.011), increased biologic age in GG genotype carriers (p=0.042), if compared to the rest of group 2. The results obtained prove involvement of the studied polymorph locus (+1267A/G) of HSPA1B gene into mechanisms of chronic mercury intoxication development and progression, and could be considered in elaboration of personified approaches to prevention and treatment of chronic mercury intoxication.

The article covers hygienic evaluation of main hazards in vinyl chloride and polyvinyl chloride production, presents data on retrospective evaluation of workplace air pollution with vinyl chloride and 1,2-dichloroethane over many years of observations. Findings are considerable improvement of hygienic situation on the stated enterprises, specifically, significant decrease of chemical hazards and the polymer dust concentrations in air of workplace due to equipment modernization, technologic process improvement.

The examination covered workers exposed to local vibration (long length service workers without health disorder signs and patients with vibration disease). Findings are that long exposure to vibration causes compensatory increase in levels of IL-1b and protein S-100b, lower levels of IgA, IgM, IL-4, TNFa. Vibration disease development was associated with decrease of IL-1b, IgG, protein S-100b and increase of TNFa. Discriminant analysis helped to justify the most informative laboratory biomarkers in vibration disease diagnosis - protein S-100b and TNFa.

The authors present results of granulometric and morphologic analysis of dust particles in workplace air of electrolytic aluminium production. Dimensions and morphology of 6339 separate particles were assessed by scanning electronic microscopy. Findings are that fractions less than 10 micrometers covered up to 95% of the general structure. Maximal mass of low-dispersed fractions was seen in workplace air of anode operator and crane-operator.

The article covers legal problems of digital economics or “Industry 4.0”, and National technologic initiative based mostly on informational communication technologies. The authors demonstrated changes and increases in professional community for digital economics, including new medical occupations for preventive medicine. Based on analysis of work conditions for information technologies workers in EU, and of trends and prospects, the authors sysematized advantages and drawbacks of digital economics from occupational medicine viewpoint. Necessity to specify new occupational descriptive parameters and criteria for evaluating emotional strain of operators, as well as methods and criteria in medical psychology and occupational pathology to evaluate borderline conditions of cognitive functions and psychosomatic disorders, based on allostatic exertion assessment in chronic stress. As digital economics develops on basis of informational communication technologies, informational hygiene as a new sphere of occupational medicine becomes a priority.

Problems of healthy lifestyle and prevention of noninfectious diseases in recent years have been under observation of international and national organizations responsible for health and well-being of population. Moreover, many successful enterprises, understanding evident profit from the programs on healthy lifestyle formation, implement measures promoting healthy habits in the workers and their family members. These measures in general complete initiatives provided by RF government and are significant benefits for workers, employers and society in general. The article considers experience of “Healthy nutrition” program implementation as a part of preventive measures system aimed at rational nutrition of workers in major coal-extracting enterprise in Kuzbass, and presents first results obtained.