For biomonitoring of exposure in workers with insectocaricides, the authors created a method of multi-component assessment of low levels of neonicotinomides in workers' urine, based on last generation tandem liquid mass-spectrometry (triple quadrupole) with ionization source - electrostatic dispersion (positive ionization) in dynamic multi-reaction monitoring with two transitions of parent ions (for quantitative assessment and ionic ratio confirmation). After the work, the operators gave urine samples (about 100 ml in average) that were frozen and kept under -20°C before analysis. Samples were defrozen before analysis, and each urine portion of 5 ml was diluted by equal volume of 0,1% formic acid. To extract substances out of the samples, solid-phase extraction (cartridges based on octadecylsilane) was applied, elution was performed with 1 ml of methanol. Lower limit of the substances detection in urine - 0,02-0,05 ng/ml, lower limit of the quantitative assessment - 0,1-0,2 ng/ml. The method was tested on monitoring of the workers' exposure to preparations based on imidaclopride and clotianidine in natural conditions of pesticides use in agriculture with various processing technologies. Imidacloprid was identified in urine of 3 professional operators after wheat and oat seeds treatment and after subsequent seeding at lower limit of detection (0,02 ng/ml), lower limit of quantitative assessment (0,1 ng/ ml) and 0,34 ng/ml.

Comparative evaluation of clinical, neurophysiologic and laboratory data changes in 154 workers exposed to vibration in mining industry helped to identify the most informative criteria of vibration disease diagnosis. Scientifically justified use of neurospecific parameters - S100B protein and neurospecific enolase - was aimed to evaluate vibration disease severity.

The authors presented results of hygienic evaluation of various techonologies connected with use of fipronil-based insecticides. Findings are allowable risk of fipronil exposure in workers, if technologic regulations and safety rules met. Exceeded allowable risk in some technologies is due to technologic process features, outdated equipment and poor efficiency of individual protective means - that requires management decisions.

Examination of 648 workers in ore mining and processing enterprises demonstrated role of psycho-social factors in diagnosis and development of occupationally conditioned dorsopathies, revealed the most important occupational and non-occupational factors influencing dorsopathies development. Findings also are clinical and psychologic criteria of health disorders in workers with occupationally conditioned dorsopathies. The authors suggested scientifically justified approaches to preventions of dorsopathies and to workers' health preservation.

The article covers studies on determining priority risk factors for health of female workers of heat-and-power engineering enterprise, risk groups revealed, suggestions for medical examinations with investigations in early diagnosis of cardiovascular system dysadaptation.

The article presents results of hygienic studies on work conditions in using imidacloprid-based pesticides in agriculture. Analysis covered imidacloprid levels in air of workplace, on skin and in urine of workers.

The authors revealed influence of occupational vibration on development of resistance to insulin and of II type diabetes mellitus in miners. With that, increased serum insulin level was diagnosed in the workers. Occurrence of patients with increased insulin level reaches 70% in vibration disease. The most intensively changed indexes are CARO and HOMA-IR, that identify early latent changes in resistance to insulin. Vibration appeared to influence significantly on II type diabetes mellitus development. Prevalence of II type diabetes mellitus among vibration disease patients is 5 times higher than that in general population of Russian Federation.

Hygienic evaluation covered work conditions and health state of medical personnel working with magnetic resonance tomographs. Work conditions of the medical personnel are characterized by a complex of hazards: constant magnetic field, increased intensity and hardiness of work, inadequate natural illumination, noise. The most unfavorable conditions are seen in diagnostic room during patients' preparation to the examination, where magnetic induction levels considerably exceed maximally allowable levels. The authors revealed reliable differences in functional parameters indicative of lower adaptational body resources in work with magnetic resonance tomographs. Suggestions are preventive measures to provide hygienic safety for medical personnel.

Using a complex of contemporary audiologic methods (high-frequency audiometry, acoustic reflexometry, registration of otoacoustic emission at aberration product frequency), examination covered 483 underground miners exposed to intensive noise. The most sensitive methods to diagnose early changes in fuctional state of hearing analyser at stage when tonal audiometry fails to determine hearing thresholds are otoacoustic emission at aberration product frequency (sensitivity 75%) and hearing study in extended frequency rating (sensitivity 65%). The authors specified a complex of informative parameters for early diagnosis and group risk identification of occupational deafness. Advisability is to include contemporary electroacoustic and neurophysiologic audiologic methods into routine periodic medical examinations.

Comparative analysis covered emotional personality disorders in vibration disease patients in dependence on presence and intensity of androgen deficiency. Parameters of depression, personal and actual anxiety in vibration disease patients are reliably higher in those with marked clinical and laboratory signs of androgen deficiency.

Deep clinical instrumental examination covered workers of National research center «Kurchatovsky Institute», who are exposed to complex of occupational hazards, to diagnose endocrine disease and assess complications risk. Suggestions are to proceed with specified timely treatment and prophylaxis for optimal health of the examinees and possible complications prevention.

The article is aimed to systematically review evidence-based data published in foreign literature on influence of level and characteristics of occupational noise on hearing loss. Search of the literature was based on key words “occupational noise exposure, permissible exposure limit, dose-response relationship, acceptable noise level, noise-induced hearing loss”. The authors studied 349 publications, 7 out of which were included into the present systematic review. Findings are that developed countries demonstrate a tendency to decreased prevalence of hearing loss among workers exposed to noise. Occupational groups with increased risk include workers of mining, machinery, light industries and agriculture. Lower occupational risk or no risk of hearing loss is seen in education, transport workers, musicians and other groups. Occupational noise level of 80 dB is a theoretically minimal exposure level resulting in no increase in hearing loss risk. Following normal noise level at 85 dB could decrease prevalence of hearing loss due to noise.

In lead intoxication model, with hyperglycemia state, atherogenicity coefficient reached 1,45 (1,35-1,85), if compared to 1,30 (0,85-1,40) in white rats exposed to lead. Heart rate reached 421,00 (411,00-468,00) per minute vs, 385,50 (359,00-399,50) per minute in animals died with lead intoxication, shorter median interval between QRS-complexes up to 143,00 (128,00-146,00) ms vs, 160,00 (150,50-169,00) ms was seen in animals exposed to lead.

The study included 335 males who were exposed to occupational hazards over 5 years to the moment of cerebrovascular stroke. The authors analysed structure of clinical forms of cerebrovascular stroke, found a concept of various age groups distribution in dependence on occupational factor type, established a frequency of cardiovascular risk factors distribution among males in dependence on occupational hazards, revealed forecasting value of intensity ranks in cerebrovascular stroke patients at the disease presentation.