Influence of radiation exposure on occurrence of radiation sickness and acute leucemia

The authors present data of prolonged clinical observation of patient underwent relatively uniform radiation exposure (4,3 Gy). Stable RBC and WBC counts within normal ranges were seen over 27 years. Neutrophils count transitory exceeded normal values probably due to exacerbation of chronic diseases in the patient (chronic tonsillitis and chronic bronchitis). Lymphocyte and platelet conts were the least stable: frequent lymphocytosis, lymphopenia and nearly constant (over 27 years) transitory moderate thrombocytopenia. Usually thrombocytopenia was considered as a manifestation of chronic persistent hepatitis. Cytogenetic studies of peripheral lymphocytes cultures via trichromatic FISH-method demonstrated presence of high levels of translocations - that indicates their presence in other cell lines and could be a source of malignant transformation. The discussion section considers various ways of leucosis clone formation. The conclusion stresses that the studied leucemia case is a polyethiologic disease with undoubtfully high contribution of accidental radiation exposure.

острый лейкоз, авария на Чернобыльской АЭС, аберрации хромосом, культура лимфоцитов периферической крови, костный мозг, acute leucemia, Chernobyl nuclear power station accident, chromosomal aberrations, peripheral lymphocytes culture, bone marrow

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