Toxicological assessment of ammonium, sodium and potassium peroxidisulfate

The article presents a comprehensive overview of the toxicological characteristics of persulfate salts (ammonium, sodium and potassium), widely used in various industries. The study aims to systematize modern scientific data on the toxic effect of persulfates on the animal body at various routes of entry and levels of exposure.

The research methodology included an information and analytical approach using PubMed, Google Scholar, and eLibrary databases.RU and specialized toxicological registers.

The authors conducted an analysis of experimental studies of acute, subchronic toxicity, local irritant effect and sensitizing properties of persulfate salts.

The results of the study have showed that sulfate ion is the main toxicologically significant component of persulfate compounds. The main mechanisms of toxic action have been established: neurological disorders, systemic organ damage, respiratory disorders, local irritant effects on the skin and mucous membranes. Scientists have identified differences in the toxicity of salts depending on the cation: potassium persulfate is the safest, ammonium persulfate is the most toxic.

The scientific novelty of the work lies in the comprehensive assessment of the toxicological properties of persulfate salts and the identification of the need for further study, especially of sodium persulfate.

The practical significance of the study is to substantiate the need to develop a full-fledged regulatory framework for persulfate salts in order to ensure sanitary and epidemiological safety.

Contributions:
Fedotova L.A. — development of research design, writing the text of the manuscript, review of publications on the topic of the article, analysis of the data obtained, editing of the material, systematization of data, conceptualization, approval of the final version of the article;
Manaeva E.S. — development of the research design, writing the text of the manuscript, review of publications on the topic of the article, analysis of the data obtained, approval of the final version of the article;
Tonshin A.A. — editing of the material, systematization of data, conceptualization, approval of the final version of the article.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 30.10.2025 / Accepted: 14.12.2025 / Published: 15.02.2026

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