zurniimtpeМедицина труда и промышленная экологияRussian Journal of Occupational Health and Industrial Ecology1026-94282618-8945FSBSI “Izmerov Research Institute of Occupational Health”10.31089/1026-9428-2026-66-1-39-48ejcbpnzurniimtpe-4041Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSТоксикологическая оценка пероксидисульфата аммония, натрия и калияToxicological assessment of ammonium, sodium and potassium peroxidisulfatehttps://orcid.org/0000-0003-0089-5177ФедотоваЛионэлла АйдыновнаFedotovaLionella A.

Вед. науч. сотр. отдела профилактической токсикологии и медико-биологических исследований ФГБУ «Центр стратегического планирования и управления медико-биологическими рисками здоровью» ФМБА России, ведущий научный сотрудник отдела токсикологии и биопрофилактики ФБУН «Екатеринбургский медицинский научный центр профилактики и охраны здоровья рабочих промпредприятий» Роспотребнадзора, канд. мед. наук

e-mail: LFedotova@cspfmba.ru

Leading Researcher, Department Of Preventive Toxicology And Medical And Biological Research (Centre for Strategic Planning); Leading Researcher, Department of Toxicology and Bioprevention (Yekaterinburg Medical Research Center Prevention and Occupational Health of Industrial Workers), Cand. of Sci. (Med.)

e-mail: LFedotova@cspfmba.ru

LFedotova@cspfmba.ruhttps://orcid.org/0000-0003-1048-6342МанаеваЕлизавета СергеевнаManaevaElizaveta S.

Ст. науч. сотр. отдела профилактической токсикологии и медико-биологических исследований ФГБУ «Центр стратегического планирования и управления медико-биологическими рисками здоровью» ФМБА России, канд. биол. наук

e-mail: EManaeva@cspfmba.ru

Senior Researcher, Department Of Preventive Toxicology And Medical And Biological Research (Centre for Strategic Planning), Cand. of Sci. (Biol.)

e-mail: EManaeva@cspfmba.ru

EManaeva@cspfmba.ruТоньшинАнтон АлександровичTonshinAnton A.

Зав. лаб. токсикологии ФГБНУ «Научно-исследовательский институт медицины труда имени академика Н.Ф. Измерова», канд. биол. наук.

e-mail: atonshin@yandex.ru

Head Of The Toxicology Laboratory (Izmerov Research Institute of Occupational Health), Cand. of Sci. (Biol.)

e-mail: atonshin@yandex.ru

atonshin@yandex.ruФГБУ «Центр стратегического планирования и управления медико-биологическими рисками здоровью» ФМБА России; ФБУН «Екатеринбургский медицинский научный центр профилактики и охраны здоровья рабочих промпредприятий» РоспотребнадзораРоссияCentre for Strategic Planning, of the Federal medical and biological agency; Yekaterinburg Medical Research Center Prevention and Occupational Health of Industrial WorkersRussian FederationФГБУ «Центр стратегического планирования и управления медико-биологическими рисками здоровью» ФМБА РоссииРоссияCentre for Strategic Planning, of the Federal medical and biological agencyRussian FederationФГБНУ «Научно-исследовательский институт медицины труда имени академика Н.Ф. Измерова»РоссияIzmerov Research Institute of Occupational HealthRussian Federation2026150220266613948Copyright © Федотова Л.А., Манаева Е.С., Тоньшин А.А., 20262026Федотова Л.А., Манаева Е.С., Тоньшин А.А.Fedotova L.A., Manaeva E.S., Tonshin A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.journal-irioh.ru/jour/article/view/4041

Представлен комплексный обзор токсикологических характеристик персульфатных солей (аммония, натрия и калия), широко применяемых в различных отраслях промышленности. Цель исследования — систематизация современных научных данных о токсическом действии персульфатов на организм животных при различных путях поступления и уровнях воздействия.

Методология исследования включала информационно-аналитический подход с использованием баз данных PubMed, Google Scholar, eLIBRARY.RU и специализированных токсикологических регистров. Проведён анализ экспериментальных исследований острой, субхронической токсичности, местно-раздражающего действия, сенсибилизирующих свойств персульфатных солей.

Результаты исследования показали, что сульфат-ион является основным токсикологически значимым компонентом персульфатных соединений. Установлены основные механизмы токсического действия: неврологические нарушения, системные поражения органов, респираторные расстройства, местно-раздражающее воздействие на кожу и слизистые оболочки. Выявлены различия в токсичности солей в зависимости от катиона: персульфат калия является наиболее безопасным, персульфат аммония — наиболее токсичным.

Научная новизна работы заключается в комплексной оценке токсикологических свойств персульфатных солей и выявлении необходимости дальнейшего изучения, особенно персульфата натрия. Практическая значимость исследования состоит в обосновании потребности разработки полноценной нормативной базы для персульфатных солей с целью обеспечения санитарно-эпидемиологической безопасности.

Участие авторов

Участие авторов:Федотова Л.А. — разработка дизайна исследования, написание текста рукописи, обзор публикаций по теме статьи, анализ полученных данных, редактирование материала, систематизация данных, концептуализация, утверждение окончательного варианта статьи;Манаева Е.С. — разработка дизайна исследования, написание текста рукописи, обзор публикаций по теме статьи, анализ полученных данных, утверждение окончательного варианта статьи;Тоньшин А.А. — редактирование материала, систематизация данных, концептуализация, утверждение окончательного варианта статьи.

Финансирование

Финансирование. Исследование не имело спонсорской поддержки.

Конфликт интересов

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Дата поступления

Дата поступления: 30.10.2025 / Дата принятия к печати: 14.12.2025 / Дата публикации: 15.02.2026

The article presents a comprehensive overview of the toxicological characteristics of persulfate salts (ammonium, sodium and potassium), widely used in various industries. The study aims to systematize modern scientific data on the toxic effect of persulfates on the animal body at various routes of entry and levels of exposure.

The research methodology included an information and analytical approach using PubMed, Google Scholar, and eLibrary databases.RU and specialized toxicological registers.

The authors conducted an analysis of experimental studies of acute, subchronic toxicity, local irritant effect and sensitizing properties of persulfate salts.

The results of the study have showed that sulfate ion is the main toxicologically significant component of persulfate compounds. The main mechanisms of toxic action have been established: neurological disorders, systemic organ damage, respiratory disorders, local irritant effects on the skin and mucous membranes. Scientists have identified differences in the toxicity of salts depending on the cation: potassium persulfate is the safest, ammonium persulfate is the most toxic.

The scientific novelty of the work lies in the comprehensive assessment of the toxicological properties of persulfate salts and the identification of the need for further study, especially of sodium persulfate.

The practical significance of the study is to substantiate the need to develop a full-fledged regulatory framework for persulfate salts in order to ensure sanitary and epidemiological safety.

Contributions

Contributions:Fedotova L.A. — development of research design, writing the text of the manuscript, review of publications on the topic of the article, analysis of the data obtained, editing of the material, systematization of data, conceptualization, approval of the final version of the article;Manaeva E.S. — development of the research design, writing the text of the manuscript, review of publications on the topic of the article, analysis of the data obtained, approval of the final version of the article;Tonshin A.A. — editing of the material, systematization of data, conceptualization, approval of the final version of the article.

Funding

Funding. The study had no funding.

Conflict of interest

Conflict of interest. The authors declare no conflict of interest.

Received

Received: 30.10.2025 / Accepted: 14.12.2025 / Published: 15.02.2026

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The authors declare that there are no conflicts of interest present.