Analysis of relationships between biochemical markers of endothelial dysfunction in chronic mercury exposure

Abstract

Introduction. The cause of the development of endothelial dysfunction (ED) and, as a result, the pathology of the cardiovascular system may be exposure to mercury.

The aim of study is to study the relationship between ED markers in individuals exposed to mercury.

Materials and methods. A survey was carried out using biochemical and statistical methods in persons exposed to mercury with more than five years of work experience, and in patients with chronic mercury intoxication in the long-term post-exposure period.

Results. Relationships of biochemical indicators of ED of various directions have been established, indicating the presence of pathological changes in the endothelium of vessels in which its different links are involved.

Conclusions. Associations were established between the exposition load and the concentration of ED markers in workers without occupational disease, which indicates the contribution of production factors to its formation during contact with the toxicant. The results of the study of the correlation of biochemical indicators of ED indicate the presence of complex associations that form a closed system between its markers at the stage before the formation of occupational disease, and their disunity in the distant period of chronic mercury intoxication, especially in the presence of CVD.