Effect of radon therapy on epithelial cells of the respiratory tract mucosa in patients with occupational chronic obstructive pulmonary disease

The influence of natural radon waters on the state of the respiratory tract mucosal cells in patients working in the coal and metallurgical industries with occupational chronic obstructive pulmonary disease was studied. The positive effect of common radon baths on the restoration of cytological changes in the respiratory mucosa was revealed.

Indicators of local immunity of the respiratory tract mucosa in patients with occupational chronic obstructive pulmonary disease on the background of the use of general radon baths.

The aim of the study is to explore the effect of natural radon water in the form of shared baths on epithelial cells of the respiratory mucosa in patients with occupational chronic obstructive pulmonary disease based on the analysis of cytological changes in the respiratory mucosa. Patients of the main group with professional chronic obstructive pulmonary disease were given general radon baths from a natural source in sanatorium conditions. Patients in the control group had shared freshwater baths. All patients before and after treatment studies were conducted cytologic changes in the smears from the mucous membrane of the nose and phlegm. The use of common radon baths in the main group revealed a pronounced corrective effect on the function of cellular protection of the respiratory mucosa, which was expressed in a significant decrease in destructive processes in cells of all types with an increase in their functional activity, normalization of mucociliary clearance. There were no significant changes in indicators in the control group.

The use of common radon baths at the stage of rehabilitation in workers of the coal and metallurgical industry with professional chronic obstructive pulmonary disease leads to the restoration of the integrity of the cellular composition of the epithelial cover of the respiratory tract mucosa, preserves the functional activity of cells of local protection factors.

The authors declare no conflict of interests.

1. Smirnova I.N., Antipova I.I., Zaripova T.N. Local immunity protection of a respiratory path at galoaerozoltherapy. In: Materials V of Anniversary congress of immunologists and allergists of the CIS. SPb.; 2003: 38 (in Russian).

2. Chronic obstructive illness easy. Clinical recommendations. Professional associations. Th e Russian respiratory society. M.; 2018 (in Russian)

3. Chuchalin A.G., ed. Pulmonology. A national management (manual). M.: GEOTAR-MEDIA; 2014: 4 (in Russian).

4. Vasiljeva O.S. Infl uence of factors of an environment and chronic obstructive illness easy. Pulmonologiya. 2003; (6): 1–4 (in Russian).

5. Vasiljeva O.S., Kravchenko J.U. Chronic obstructive illness easy as occupational disease: risk factors and a problem of medicosocial rehabilitation of patients. Rossijskij meditsinskij zhurnal. 2015; 5 (2): 22–6 (in Russian).

6. Kosarev V.V., Babanov S.A. Occupational disease of bodies of breath. M.: Infra-î; 2013 (in Russian).

7. Chuchalin A.G., Vasilyeva O.S. Mazitova Н.Н., Kotova O.S., MarchenkoV.N. Professional chronic obstructive illness easy. In: “Occupational diseases of bodies of breath. A national management (manual)”. A series “National managements (manuals)“. Eds. N.F. Izmerov, A.G. Chuchalin. M.: GEOTAR; 2015: 293–338 (in Russian).

8. Serebrjakov P.V., Kartashov O.I., Fedin I.N. Kliniko-hygienic an estimation of a state of health of workers of manufacture of copper in conditions of Far North. Med. truda i prom. ekol. 2016; 12: 25–8 (in Russian).

9. Ignatova G.L., Stepanishcheva L.A., Mikrjukova J.A., Drozdov I.V., Galimova O.V., Grebneva I.V., Kovalenko V.N., Schusova L.M. Prevalence ХОБЛ at the large industrial enterprise (Chelyabinsk a tractor factory). Atmosfera. Pul’monologiya i allergologiya. 2003: 3 29–31 (in Russian).

10. Mazitova N.N. Professional factors and chronic obstructive illness easy: the metanalysis. Fundam. issled. 2011; 9–3: 588–92 (in Russian).

11. Samosjuk I.Z., Fedorov S.N., Dumin P.V. Radonoterapija: problems and prospects. Ukr. med. chasopis. 2000; 2: 119–23 (in Russian).

12. Karpuhin M.V., Whether А.А., Gusev M.E. Radonoterapija. M.: Geotar media; 2007 (in Russian).

13. Bogoljubov V.M., Ponomarenko G.N. General physiotherapy. Th e educational literature. M.: Geotar media 2015: 414–7 (in Russian).

14. Fahy J.V., Diskey D.F. Airway mucus function and dysfunction. N. Engl. J. Med. 2010; 363(23): 2233–47.

15. Velichkovsky B.T. Molecular and cellular bases of ecological pulmonology. Pul’monologiya. 2000; (2): 10–8 (in Russian).

16. Leontjeva E.L., Khanin A.L. Comprehensive treatment of patients with dust lesions of the lungs using prolonged bronchodilator tiotropium bromide. Med. v Kuzbasse. 2006; (S5): 72–4 (in Russian).

17. Chikina S.J., Белевский A.S. Mucociliary clearance in normal and pathology. Atmosfera. Pul’monologiya i allergologiya. 2012; 2–5 (in Russian).

18. Matveeva L.A. Method of the cytologic analysis назального a secret. In.: “Th e collection of works of Tomsk medical institute’. Tomsk; 1981: 129 (in Russian).

19. Psayis V.I. Material to clinic and treatment chronic adenoiditi. Dis. Dr. med. Sciences. M.; 1968 (in Russian).