Corrective infl uence of dihydroquercetin on oxidative metabolism state in drivers of Northern region
https://doi.org/10.31089/1026-9428-2019-3-183-187
Abstract
Professional drivers during their work are constantly subjected to toxic influence of chemical elements in automobile exhaust gases that cause excessive accumulation of lipid peroxidation products. The study covered 182 male inhabitants (aged 32,6±6,2 years) of Hanty-Mansiysk autonomous district: 94 drivers and 88 clerks. The drivers, when compared to the clerks, demonstrated reliably higher values of lipid peroxidation: lipids hydroperoxide (p = 0.026), active derivatives of thiobarbituric acid (p = 0.003), coefficient of oxidative stress (p = 0.002) with lower parameters of antioxidant system: general antioxidant activity (p<0.001), thiolic state (p = 0.002). After 3 months of correction by means of natural antioxidant dihydroquercetin (75 mg daily), the drivers demonstrated not only statistically significant decrease of lipid peroxidation parameters: lipids hydroperoxide, coefficient of oxidative stress (p = 0.007) and increased values of antioxidant system: general antioxidant activity (p = 0.003), thiolic state (p = 0.05), but also considerable improvement of general state and performance.
About the Authors
V. I. Korchin
Khanty-Mansiysk State Medical Academy
Russian Federation
Russian Federation
T. Ya. Korchina
Khanty-Mansiysk State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Korchin V.I., Korchina T.Ya. Corrective infl uence of dihydroquercetin on oxidative metabolism state in drivers of Northern region. Russian Journal of Occupational Health and Industrial Ecology. 2019;(3):183-187. (In Russ.) https://doi.org/10.31089/1026-9428-2019-3-183-187
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