Carcinogenic and genotoxic risks of combined exposure to dust and radiation in oxidative stress environment
Laura Ye. Chulenbayeva,
Sergey V. Kashanskiy,
Kenzhekyz B. Manekenova,
Gulzhan O. Ilderbayeva,
Talgat M. Omarov,
Oralbek Z. Ilderbayev https://doi.org/10.31089/1026-9428-2018-11-60-64
Abstract
Rats subjected to coal dust combined with radiation dose of 6 Gy in long-term period demonstrated cytogenetic disorders and changes in bronchial mucosa, arterial and arterioli walls in lung stroma, destructive changes in liver parenchyma with colliquation necrosis foci in liver lobules, on oxidative stress background. Findings are that combined experimental exposure to dust and radiation on oxidative stress background increases carcinogenic and genotoxic risks in animals.
Keywords
coal dust,
radiation,
combined exposure,
long-term period,
oxidative stress,
micronuclei,
fibrosis,
necrosis
Supporting agencies: The work was supported by the Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan, scientific project No. 0115РК01415.
About the Authors
Laura Ye. Chulenbayeva
L.N. Gumilyov Eurasian National University
Kazakhstan
5, K. Munaytpasova str., Astana, 010008
Kazakhstan
5, K. Munaytpasova str., Astana, 010008
Sergey V. Kashanskiy
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
Russian Federation
30, Popova str., Yekaterinburg, 620014
Russian Federation
30, Popova str., Yekaterinburg, 620014
Kenzhekyz B. Manekenova
JSC «Astana Medical University»
Kazakhstan
49A, Beybutshilik str., Astana, 010000
Kazakhstan
49A, Beybutshilik str., Astana, 010000
Gulzhan O. Ilderbayeva
Semey State Medical University
Kazakhstan
103, Abaya Kunanbayeva, Semey town, 071400
Kazakhstan
103, Abaya Kunanbayeva, Semey town, 071400
Talgat M. Omarov
JSC «Astana Medical University»
Kazakhstan
49A, Beybutshilik str., Astana, 010000
Kazakhstan
49A, Beybutshilik str., Astana, 010000
Oralbek Z. Ilderbayev
L.N. Gumilyov Eurasian National University
Kazakhstan
5, K. Munaytpasova str., Astana, 010008
Kazakhstan
5, K. Munaytpasova str., Astana, 010008
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Review
For citations:
Chulenbayeva L.Ye., Kashanskiy S.V., Manekenova K.B., Ilderbayeva G.O., Omarov T.M., Ilderbayev O.Z. Carcinogenic and genotoxic risks of combined exposure to dust and radiation in oxidative stress environment. Russian Journal of Occupational Health and Industrial Ecology. 2018;(11):60-64. (In Russ.) https://doi.org/10.31089/1026-9428-2018-11-60-64
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