The authors present review of themes covered by Novosibirsk Research Hygiene Institute and the study results obtained over recent years. Evidences are that industrial Siberian centers demonstrate general positive changes in environmental pollution decrease and better health state of children and adolescents, but the situation remains warning about medical and sanitary care for workers engaged into hazardous work conditions, about lower diagnostic coverage of occupational diseases in periodic medical examinations. Facts are that qualified early diagnosis of primary signs of workers' disablement and opportune rehabilitation and preventive treatment enable to stop occupational diseases formation.

Based on spectral analysis of heart rhythm variability, studies covered changes in vegetative regulation in patients with occupational dorsopathies of cervical and lumbar regions. Findings are that 75% of patients with occupational dorsopathies have marked vegetative disorders - insufficient activity of sympathetic nervous system and drastic dominance of parasympathetic regulatory mechanisms due to pathologic vertebrogenous influences on peripheral vegetative structures. The most informative stress testing to reveal vegetative dysfunction in patients with occupational dorsopathies is flexion test. Individuals with occupational dorsopathies and dominant parasympathetic regulatory mechanisms have more severe prognosis due to more frequent severe degenerative and dystrophic spinaI changes.

The article covers data on prevalence of neurosensory deafness among civil aircraft crew members. The study revealed high level of neurosensory deafness in civil aircraft crew members, averaging to 50.8% in neurosensory deafness structure among noise-related occupations. Arterial hypertension appeared to be the most prevalent concurrent disease in civil aircraft crew members with neurosensory deafness, found in 47.5% of the patients examined - that considers arterial hypertension as a factor of neurosensory deafness progression.

The article covers implementation of regulatory and legal concepts in prevention of risk caused by hazardous effects of noise in civil aviation flight personnel. The authors analyzed case histories of civil aviation flight personnel patients examined in occupational diseases clinic, with first diagnosed occupational neurosensory deafness

Analyzing distribution of genotype polymorphism occurrence of Pro198Leu gene of GPX1 (glutathion peroxidase) and Ala 16 Val gene of MnSOD (superoxide dismutase), the authors presented major mechanisms and leading pathogenetic factors of vibration disease formation and course in post-contact period. The article covers also results of metabolic processes evaluation in patients with varying resistence to occupational vibration, for forecasting its course after discontinued contact with the factor.

The article deals with results of cardiorespiratory status study in professional guttural singers. Findings are that long length of service in “hoomey” style professional guttural singers results in lower external respiration parameters and RBC saturation values. Ultrasound investigation demonstrates reliably more frequent left ventricle hypertrophy. The results obtained necessitate specification of programs for complex evaluation of occupational risks and for prevention of occupational and occupationally mediated diseases in guttural singers.

Increased length of service in house-painters causes longer half-periods of adaptation and recovery, larger their total, lower coefficient of recovery and lower coefficient of myocardial resources expenditure. That indicates lower efficiency of heart action under exertion, poor adaptive reactions to physical exertion and latent heart failure formation.

The article covers topics of possible local methods to treat pain in occupational diseases. Local pain treatment was implemented in patients of occupational diseases clinic, having locomotory and peripheral nervous system diseases.

The authors found statistically significant differences in cognitive tests results between group of drivers and reference group (p = 0,021). Correlation analysis proves statistically reliable relationship between cognitive functions and hemodynamic as well as morphologic parameters of cardiovascular system.

The authors analysed health state and morbidity of women engaged into professional navy service in North Fleet, age features of health state in these servicewomen, and results of medical stationary examination and checkup results, regular medical examination results and the servicewomen morbidity over 12 years (about 15.5 thousand cases), and 697 reports on the servicewomen diseases according to military medical (navy) commission. The article covers causes of changes in navy fitness category for the servicewomen, analysis of comorbidity, suggestions of new approaches to comorbidity analysis.