In 2015, Federal Service on surveillance in consumers rights protection and public well-being set a task to organize planned work of regional agencies on basis of risk-oriented model of control and supervision. Based on results of pilot project in Rospotrebnadzor Department of Perm area and St-Petersburg, the article covers methodic approaches to classification of objects liable to surveillance in occupational hygiene. The classification considers possibility of sanitary law violation, severity of this violation consequences and number of workers exposed to risk factors including hazardous work conditions. The authors specified recommendations on periodicity and forms of planned inspections considering evaluation of potential risk for human health, determined problems that require solution in implementation of riskoriented model of surveillance.

The article presents results of evaluation of a priori and a posteriori occupational risks for workers engaged into underground mining. Evidence is that work conditions of major occupational groups of workers engaged into underground mining, according to workplace certification, correspond to 3 class 3 jeopardy degree. A priori risk of diseases development corresponds to high (unbearable). Evaluation of cause-effect relationship between health disorders and work conditions revealed a medium degree of occupational conditionality for vascular regulation disorders and metabolic disorders, that can be considered as cardiorisk indicators.

The article covers changes in occupational cardiovascular risk for workers of nonferrous metallurgy. Findings are that exposure to noise up to 94 dB with length of service increases possible atherosclerosis and metabolic syndrome. With 5 years of service, risk of the predicted conditions increases by 40.5%. When occupational exposure lasts over 5 years, risk of arterial hypertension increases. A group of workers without exposure to occupational factors appeared to have no connection between length of service and metabolic syndrome and arterial hypertension. Risk evolution modelling proved that risk of functional disorders in nonferrous metallurgy workers becomes unacceptable aft er 5 years of service (cardiovascular disorders are critical).

The study covered prevalence of endometriosis under various levels of exposure to chemical environmental factors and chemical risk factors for immune and reproductive female systems, identified as exposure markers in sanitary epidemiologic studies. Findings are that a part of inhabited area neighbouring to industrial territory is characterized by unacceptable risk of immune disorders and reproductive system diseases due to chronic exposure to formaldehyde, nickel, lead, benzene, that can result in increased prevalence of endometriosis.

The article contains results of studies characterizing nanoparticles in blood and serum of exposed workers engaged into titanium and magnesium production and workers outside coverage of occupational factors. Comparative study of the workers’ serum included dynamic light dispersion, scanning electronic microscopy, transmission electronic microscopy. Measuring despersion characteristic of blood serum in the workers exposed to nanomaterial revealed increased percentage of particles with hydrodynamic diameter within 60–100 nm and over 100 nm.

The study covered genetically determined lipid metabolism disorders due to oral intake of technogenic hyperchlorination drinkable water products. Findings are that overweight and obese children in a main group appeared to have serum chloroform level 2.3 times higher than that in a reference group. In oral intake of hyperchlorination drinkable water products, the study revealed main genes having polymorphism associated with endocrine disorders: overweight and obesity  — APOE, PPARG, HTR2A, characterizing antioxidant system state  — SOD2 and detoxication  — SULTA. Polymorphism of candidate genes HTR2A and SOD2 was characterized by increased occurrence of mutant homo  — and heterozygous genotype, relative risk of pathologic allele presence in population exceeded the refrence group values. Probability of increased serum serotonin and lower Cu/Zn in children with mutant homozygous genotype HTR2A and SOD2 is 1.2–1.3 times higher than in those with heterozygous and normal homozygous genotypes.

The article covers problems of risk communication system function on industrial enterprise. Sociologic study in machinery construction enterprise of Perm area helped to consider main procedures of informing on occupational risk for health of workers exposed to occupational hazards, to describe features and mechanisms of risk communication, to specify its model. Th e authors proved that main obstacles for efficient system of occupational risks communication are insufficiently thorough legal basis, low corporative social responsibility of the enterprise and low social value of health for workers. Th is article was prepared with the support of the Russian Humanitarian Science Foundation (Project No. 14-16-59011).

Complex clinical, functional an laboratory examination of children living under unacceptable risk conditions due to aerogenous exposure to cadmium, chromium, lead and phenol revealed that kidney diseases associated with exposure to metals and phenol develop in children with genetic predisposition to disordered biotransformation of chemicals — polymorphism of genes CYPOX, RCYT 450, SULTA1 in homozygous and heterozygous variants. Increased levels of chemicals in blood causes microcirculation disorders in renal cortex, direct toxic effect in nephrons, suppresses activity of anitoxidant defense on cellular and systemic levels. The authors specifi ed pathogenetically based complex of clinical and laboratory diagnostic markers of chronic kidney diseases associated with exposure to metals (cadmium, chromium, lead) and oxygen-containing (phenol) organic compounds.

The article considers mechanisms of development and progression of osteoarthrosis as an occupationally conditioned disease in women of manual work. Women working in physical overstrain conditions are under occupational risk with dysfunction of many body systems. The authors set a hypothesis on association of endothelial dysfunction markers dysbalance and structural remodelling of cartilage matrix as a proof of degenerative changes.