Kazakhstan Republic has formed many antropogenous ecologic landscapes, unfavorable artificial provinces for population. That necessitates creation of ecologically favorable environment and harmonization of relationships between society and environment. The authors present experience of National center for industrial medicine and occupational diseases in medical ecology, demonstrate objectives of research and technologic programs performed earlier and at present by the center staffers. Objects and methods of studies are presented along with results and conclusions. The authors presented strategic trends of medical ecology development in Kazakhstan Republic - that can help to define patterns of various body systems injury and to justify early diagnostic criteria for ecologically dependent diseases, to create conditions for public health preservation in ecological ill-being.

The article covers analysis of total ranking of intense parameters in three blocks of complex evaluation of Priaralye adult population - epidemiologic, clinical and social hygienic. Analysis covered 9 settlements of Priaralye and their location area of disaster zones (Aral'sk town, Aitekebi settlement and Shalkar town), crisis zone (Shieli, Zhalagashskyi, Zhosaly settlements), pre-crisis zone (Arys' town, Irgiz and Ulytau settlements) and reference poiint (Atasu settlement) in Kazakhstan. Epidemiologic block considered retrospective data on primary morbidity and its prevalence, mortality. Clinical block included ranking of medical examination results, social hygienic block incorporated polling data on health state complaints. Consideration included 4 classes of presumably ecologically dependent respiratory diseases, gastro-intestinal disorders, cardiovascular and urinary illnesses. Total ranks of the studied settlements of Priaralye in epidemiologic, clinical and social blocks were corresponding to distribution zones of ecologic stress in territories.

The article presents results of hygienic, clinical and laboratory studies concerning dependence of mieloperoxidase level in males residing in ecologically unfavorable area of Kazakhstan (Taraz town) on polycholrbiphenols content of air. Polycholrbiphenols content appeared to be 2-3 times exceeded among suspended particles of ambient air. The enzyme activity appeared to be changed in the examinees group (p < 0,05), statistically significant decrease of the enzyme was seen in 48% of the examinees. Reliable invert correlation was seen between lower mieloperoxydase activity and polychlorbiphenol concentration - that was at r = - 0,82 (p < 0.05). Mieloperoxidase activity indicates its sensitivity to xenobiotics influence in dependence on the exposure duration. Studies of mieloperoxidase activity in neutrophils can serve as a screening method and prenosologic diagnosis of ecologically dependent disorders in population.

Examination of relationships between occupation and disease is a leading moment in occupational medicine. According to regulatory legal documents of Kazakhstan Republic, the examination topics are considered by professional committees of National center for industrial medicine and occupational diseases in Health and Social development Ministry of Kazakhstan Republic. Complex cases of diseases etiology and disputable matters are considered by Republic Expert dispute committee on occupational diseases of Health and Social development Ministry of Kazakhstan Republic. Complete examination of relationship between disease and workers' occupational occupational therapy service development for 2016-2020.

The article covers results of sanitary hygienic monitoring of ambient air pollution in Kalachi town of Akmolinsk region. The data obtained demonstrate that ambient air pollution exceeeded MAC for carbon oxide up to 2 times, that for ozone - up to 2-4 times, that for benzene - up to 6.3-11 times. Radiation studies support that internal irradiation with radon is a major radiation source for population. Average volume activity of radon in chambers is nearly 10 times over the MAC.

The authors studied features of congitive state and emotional profile in cerebrovascular diseases of Shieli settlement inhabitants. Clinical manifestations and cerebrovascular diseases severity among the inhabitants are presented.

The authors presented data of social poll and medical biologic study of public health in Irgiz settlement and Shalkar town in Atkiubinsk region, evaluated non-surgical morbidity among the examined population. About 82,5-85,8% of the examinees among north Priaralye population are assigned to the diseased group. Among the somatic diseases in Irgiz settlement, the first place is occupied by digestive disorders (61,2%), the second - by urinary disorders (43,5%), the third - by circulatory diseases (27,0%). In Shalkar town, the first place is occupied by urinary tract diseases (47,6%), the second - by digestive disorders (46,6%), the third - by circulatory system problems (29,6%). According to sociologic poll, ecologic situation in the studied regions remains unfavorable now.

The article presents results of neuropsychologic state studies in residents of Arys' town. The study of neuropsychologic state revealed high prevalence of vertebrogenous and cerebrovascular diseases among the residents. Findings are also changes in cognitive function parameters, more intense disorders of long-term memory, high levels of depression.

The authors presented comparative mathematic evaluation of functional strain in Kazakh and foreign students during study process. Object of study - Kazakh and foreign (India, Pakistan) students of medical university. Totally 89 students were examined, with physiologic, psychometric and statistic study methods. Findings are that adaptation of medical students to study process is based on functional system formation with many integral components participation, including specific (sensory, motor, intellectual) and nonspecific (activation of central nervous system, emotional tone, vegetative support). Psychophysiologic adaptation appeare to be better in foreign students, than in Kazakh ones. Mathematic modelling methods helped to specify criteria of functional strain for evaluation and forecast of functional strain levels in students during adaptation to study process.

The article covers evaluation of endocrine diseases in Priaralye residents aged 18 to 49 years. All the examinees underwent clinical and laboratory studies of thyroid gland: examination for clinical manifestations of thyroid disease, immune enzyme analysis to determine TSH level, free thyroxin and antibodies to serum thyroperoxidase, ultrasound examination of thyroid gland. The studies obtained results indicating high prevalence of thyroid diseases among the population of ecologically unfavorable area of Priaralye.

The article covers evaluation of ecologic safety of long-standing transportation of highly toxic rocket fuel - nonsymmetric dimethylhydrazine (heptyl) on territory of Kazakhstan Republic via railway transport. According to ecologic and chemical analytic studies, screening of health state of adult population, no negative influences were seen due to possible contaminationwith heptyl and its derivatives of environmental objects, natural and populated area along the transportationroute.

Complex evaluation covered work conditions of open-cast ores extraction enterprises. The authors presented changes in occupational morbidity over 2007-2014, its growth (increment coefficient 1.45), differences in the revealed morbidity structure among leading occupations. A system of occupational risks evaluation and management was specified.

The article deals with complications of silicosis that occupies important place in general occupational morbidity structure. Clinical cases of such rare complication of silicosis, as bronchial asthma and Caplan syndrome, are presented. The authors necessitate follow-up of silicosis patients for timely diagnosis and treatment of the complications.

The article covers the authors’ own observation of lung ossification in miner and immune histochemical study of pulmonary tissue sampling for epithelial mesenchymal transformation. Pulmonary fibrosis area development, bone tissue location mostly in these area, periossal location of coal dust and heterotopic character of ossification as a possible excessive morphogenetic cellular fibroblastic reaction specific for pneumoconiosis could be arguments pro ossification as anthracosilicosis manifestation. Bronchial epithelium and pulmonary fibrosis area demonstrated vimentine as a marker of low differentiated state of mesenchymal cells - that points to anthrasilicosis association with specialized bronchial epithelium cells with changed phenotype.

The authors suggest new methodic approach to analysis of relations between occupational hearing disorders (neurosensory deafness) and changed speech characteristics, as exemplified by civil aviation pilots. Analysis uses degree of correlation between parameters of hearing thresholds on audiogram and speech transfer function of speaker in identical spectral area. The study was conducted with participation of 29 pilots with clinically confirmed neurosensory deafness. The results obtained do not decline possible specific speech changes in adults with prolonged severe hearing disorder. The authors formulated main directions to increase validity of the methodic approach suggested for studying influence of hearing disorders on patients' speech characteristics.