Comparative evaluation covered work conditions in contemporary sulphate cellulose productions with various levels of mechanization and automation. Findings are that major work hazards for cellulose production workers are: polluted workplace air with chemical complex (methylsulphurous compounds, chlorine, chlorine dioxide, alkaline aerosol) in concentrations exceeding MAC, heating microclimate, noise. Levels of workplace air pollution with chemical hazards and transitory disablement morbidity parameters are considerably lower in highly automated production.

The article presents results of study concerning biochemical markers of endothelial dysfunction and structural changes in cardiovascular system of aluminium production workers with initial and advanced symptoms of occupationally related bronchopulmonary diseases. Common pathogenetic traits of cardiovascular diseases with initial and advanced symptoms of occupationally related bronchopulmonary diseases are disordered regulation of vascular tone due to nitrogen and plasmin, atherosclerotic plaques formation and changed cardiomyocytes function. Individuals with initial symptoms of occupationally related bronchopulmonary diseases are characterized by increased cardiomyocytes apoptosis due to circulatory disorders. Mechanisms of cardiovascular diseases for advanced symptoms of occupationally related bronchopulmonary diseases are related to disordered regulation of cellular hemostasis by nitrogen oxide and plasmin, changed regulation via b-adrenoreceptors and altered cardiomyocytes metabolism.

The article deals with frequency data on polymorphism of candidate genes participating in endothelial dysfunction (EDN1 Lys198Asn, NOS3 T786C, AGT Thr174Met and AGT Met235Thr) in totality with concentrations of their active substances in individuals exposed to mercury. Findings are changes in levels of nitrogen oxide, endothelin-1, angiotensin II metabolites in examinees including those without cardiovascular diseases. The genetic conditionality is connected with unfavorable genotypes of polymorphic variants - Met235Thr of AGT gene and Lys198Asn of EDN1 gene. Changes in levels of biochemical markers of endothelial dysfunction in individuals exposed to mercury indicate serious endothelial function disorders and are not genetically determined processes.

The article presents results of evaluation concerning neurophysiologic and psychoemotional state of pilots with occupational neurosensory deafness. Findings are that pilots with occupational neurosensory deafness demonstrate disorganized type of EEG, supported by fading alpha-rhythm, increased slow wave activity in delta range. Other changes are decreased conduction velocity in distal part of median and ulnar nerves - that indicates development of demyelination processes. Psychologic studies proved that personality structure in pilots with occupational neurosensory deafness has dominant traits of balanced emotional reactions, constructive ways to overcome difficulties.

Clinical immunologic and electroneuromyographic examination covered patients with vibration disease. Registered demyelination disorders on lower and upper limbs in vibration disease patients were associated with neurochemical changes in special neural structures (OBM, S-100 protein, DNA, AH-R, DA-R, Ser-R, GAMK-R). Direct proof of demyelination disorders in vibration disease patients are reliable correlation between levels of antibodies to OBM and conduction velocity in distal part of median nerve, in ulnar nerve from elbow bend and lower third of arm, and ulnar residual latency. Diagnosed relations between levels of antibodies to regulatory proteins in nervous tissue (antibodies to OBM and to S-100 protein), neurotransmitters (antibodies to AH-R, DA-R, Ser-R, GAMK-R) and functional parameters of nervous system prove important role of autoimmune reactions in vibration disease pathogenesis.

The article deals with problems arising in consideration of relations between disease and occupation. The authors presented and analyzed legal occupational therapy documents that regulate examination for connection between disease and occupational activities. Consideration also covers legal aspects and solutions of debates in complicated examination cases with specific clinical examples of legal expertise, based on experience of FGBNU VSIMEI personnel.

The article deals with methodology for integral evaluation of life quality connected with health in industrial medicine. Object of evaluation is life quality connected with health in workers exposed to occupational hazards. Empirical basis is long-standing study of life quality connected with health in patients with occupational diseases and in industrial workers. The article covers result of methologic instruments suggested by the authors for integral evaluation of life quality connected with health in workers and individuals exposed to occupational hazards, principles of group formation for such studies. The authors consider evaluation of life quality connected with health as a major goals of industrial medicine, as it completes quantitatively and qualitatively other studies of health changes in workers due to changing vital activity.

The article covers results of examination in workers engaged into railway tunnel exploitation, for health state features, in dependence on occupational factors, character and intensity of somatic diseases. The authors evaluated frequency of instrumental parameters change, analyzed clinical symptoms at manifestation and advanced disease, and its dynamics.

Number of chemicals that induce occupational sensibilization is quite large and constantly increasing due to synthesis of new compounds. Diagnosis of occupational allergic diseases requires thorough systemic approach. Study covered groups of patients that necessitate diagnosis of occupational disease (107 individuals): chemical production workers, gas-arc welder, medical staffers, aluminium production workers, with diagnosed occupational bronchopulmonary diseases. Direction of leucocytes migration in the diagnostic test used was comparable with type of a chemical under study. Correspondence of clinical manifestations and results of inhibited natural leucocytes migration test approximates 70% in chemical production workers and gas-arc welders; 85-90% - in medical staffers and 50% - in aluminium production workers.

One of the main parameters characterizing workers' health state is transitory disablement morbidity. Among the occupational groups of railway workers in Mongolia, conductors occupy first place in morbidity, with values over 2.4 times higher than an average for all railway workers. Findings are high level of occupational conditionality for cardiovascular diseases (RR = 3.22; EF = 69; c2 = 7.46) and for genito-urinary tract diseases (RR = 4.84; EF = 79; c2 = 20.21), and diseases concerning pregnancy, delivery and post-partum (other obstetric conditions) (RR = 11.85; EF = 92; c2 = 11.21).

The authors estimated fluorine compounds content of workplace air in electrolysis workshops of aluminium production, for various electrolysis technologies. The data cover results of physical and chemical analysis and material constitution of produced toxic dust complexes, urinary excretion levels of fluorine ion and fluorides accumulation in hair of aluminium production workers.

The authors presented data of chemical analytic control of chlorine compounds level in workplace air of vinyl chloride and polyvinyl chloride production, and biomonitoring results of vinyl chloride and 1.2-dichloroethane metabolite - thiodiacetic acid urinary level in workers of this production. Findings are exceeded hygienic norms on maximal concentrations of 1.2-dichloroethane in a workshop for vinyl chloride production from 1.0 to 2.85 MACs and of vinyl chloride in a workshop for polyvinyl chloride production from 2.06 to 5.52 MACs. Urinary levels of thiodiacetic acid were assessed in workers of vinyl chloride and polyvinyl chloride production in dependence on occupation, length of service and post-contact time.

The authors revealed mercury role in pathologic changes of central mechanisms underlying cerebral circulation in metabolic circle, associated with changes in central afferent pathways in thalamic region. Relationship was established between intensity of the diagnosed affect and changes in levels of antibodies to proteins S-100, general myeline protein, myeline-associated glycoprotein - that can indicate general neurodegeneration process. Antibodies level can serve as a marker of demyelination intensity in central pathways under exposure to neurotoxicants.

Hygienic work conditions on fish-processing complexes mostly remain hard and hazardous, sometimes even dangerous. Presented literature data and some personal studies characterize current state of industrial medicine topics on fish-processing enterpirses. Absence of systemic studies in these sphere rises many questions on work conditions assessment in connection with contemporary knowledge, evaluation of occupational risk and risk of occupational and occupationally conditioned diseases in major occupational groups.

The authors studied two types of morbidity among adults of Moscow over 2012-2014 - primary and occupational. Findings are that those levels in the city are significantly lower than the general in Russia. Over the studied period, the structure of both types of morbidity did not change, but there was a tendency to decrease both in total and in main entity classes of general and occupational diseases.

The article deals with problems associated with health of female migrants arriving from Tadzhikistan to Russian Federation, with consideration of physical (manual), mental exertion, social and everyday factors.