The article presents results of occupational morbidity analysis in a region, with assessment of trends, levels, dynamics and structure of morbidity, factor dependency of occupational diseases, identification of occupational conditions of its occurrence. The information obtained helped to specify a system of occupational risk management, that increases efficiency in solving problems and better work safety in production.

Analysis of health state in connection with work conditions for workers of Voronezh tire plant was based on evaluation of occupational and general morbidity according to medical examination data, hygienic characteristics of occupational factors and working process. Findings are high level of general morbidity among the workers, related to combined influence of physical and chemical occupational hazards. First rank places are occupied by locomotory system diseases (32.3%) and cardiovascular diseases (29.3%). Recommendations cover decrease of unfavorable effects of occupational hazards, minimization of occupational risks, including further improvement of work conditions and implementation of laboratory biochemical methods diagnosing premorbid conditions.

The study covered health state of medical personnel exposed to magnetic field in MRI-tomography offices. Findings are changes in functioning of cardiovascular and central nervous systems in a personnel group working with tomographs, that prove tension of adaptation processes due to occupational factors.

Tests helped to evaluate psychoneurologic state in civil aviation pilots with various stages and grades of essential hypertension. Findings are that increase of essential hypertension intensity from borderline stage to 1 stage 2 grade reliably influences psychoneurologic state of pilots. Worsening was seen for parameters of volitional attention and spatial representation (test «Landolt rings»), ability to operate spatiel representations (test «Compasses»), ability to extrapolate, rapid sensomotor reaction (test «Labyrinth»), accuracy of dynamic eye assessment and balance of main nervous processes in visual analyzer (test «Reaction to moving object»). Essential hypertension groups demonstrated dependence of the test results on age. Essential hypertension lowers parameters of the tests restults - that characterizes psychoneurologic state of pilots.

Physiologic and hygienic evaluation covered work conditions on small business enterprises of retail and minor wholesale trade. Major unfavorable occupational factor for minor retail seller of foods is work process hardiness (up to 85% of «standing»). This work affects the workers' state, with 100% reports of the health state changes by the end of the working day. Physiologic parameter «work process hardiness» in the trade workers generally was assigned to allowable (2 grade) criterion, but such parameters as work contents (work covers solving complicated problems), work in tight time conditions, responsibility and long working hours are assigned to first jeopardy degree (3.1). Minor retail trade enterprises appeared to have no work and rest schedule, that is an additional risk factor. Microclimate parameters inside the rooms are the same as outdoors, therefore necessity is to provide artificial sanitary technical systems of ventilation and heating in projects of minor retail trade networks.

Findings are that major occupational risk factors of morbidity among hothouse female workers are unfavorable microclimate parameters: in hothouses for vegetables growing - high air temperature, high relateive humidity, high air motion speed in summer; in hothouses for mushrooms growing - high humidity, forced posture work. In occupational morbidity structure of hothouse female workers, the major place is occupied by acute respiratory viral infections, respiratory diseases (20.6%) and locomotory diseases (7.9%).

The article presents studies evaluating influence of chemical and noise exposure on public health in municipal district of Voronizh city, based on risk evaluation methodology. Comparative analysis covered levels of carcinogenic, non-carcinogenic and normalized risks in monitoring control sites of the district. The studies revealed «risky» territories within the city, defined critical organs and systems under unfavorable influence by studied environmental factors.

The article presents results of study concerning relationship of educational conditions and health state of high education students in 3 institutes of Voronezh city. Subjective self-assessment of health covered first 3 years students of Voronezh State Medical university (VSMU), Voronezh State university of engineering technologies (VSUET) and Voronezh State Construction university (VSCU). Health worsening was seen in 50,2% of VSMU students, in 28,7% of VSUET students and in 23,9% of VSCU examinees since beginning of the high education, and revealed breach of legislation concerning requirements of high education conditions are nearly identical.

Search in electronic resource ProQuest Dissertations and Theses (PQDT) found 12,813 dissertation works in hygiene, prepared in foreign universities in 1992-2015. Master's degree dissertations were 99.4%, doctor's degree - 0.6%, published in English - 97.2%. In US universities were prepared 67.7% of the works, in Canada - 30.9%, in other countries - 1.4%. No Russian dissertations were found in PQDT. General hygiene topics were studied in 27.5% of the works, communal hygiene - in 5.3%, industrial hygiene and occupational diseases - in 7%, pediatric hygiene - in 20%, nutrition hygiene - in 17.8%, radiation hygiene - in 0.7%, rural hygiene - in 12.5%, hospital hygiene - in 8.3%, military hygiene - in 0.9%. Electronic resource PQDT opens wide possibilities for scientists - 89.9% dissertations in hygiene contained complete texts.

The studies revealed that work of paramedical personnel can be assigned to 2 jeopardy class in chemical factor, noise, vibration, illumination, work hardiness; in unfavorable parameters of microclimate in summer period and work intensity - to 3.1 class, in biologic factor - to 3.1-3.3 class. According to totality of factors, the work of paramedical personnel corresponds to 3.2-3.3 class of work conditions. Morbidity level of medical nurses is «very low» with minimal level of occupational risk. With that, more detailed analysis in 4 length of service groups revealed that in a group with over 15 years of service the morbidity level reaches high and extremely high (from 104.0 to 244.4 cases per 100 medical staffers). This evidence could be explained by exposure to occupational risk factors and worse health state with longer length of service and ageing.

In search of inflammatory molecular markers helpful in detection of increased risk and prognosis of severity of syntropic occupational bronchial asthma and metabolic syndrome, the authors conducted a study covering 140 examinees with confirmed occupational bronchial asthma. According to IDF criteria (2005), the patients were assigned into a group with combined occupational bronchial asthma and metabolic syndrome, and a group of occupational bronchial asthma without metabolic syndrome. All the examinees underwent studies of inflammation markers - biochemical (C-reactive protein, leptine) and molecular-genetic ( polymorphism of Gln223Arg gene of leptine receptor (LEPR), polymorphism of C174G gene of interleukin-6 (IL-6), polymorphism of G308A gene of (TNF-а) tumor necrosis factor alpha). Evidences are that the patients with combined bronchial asthma and metabolic syndrome demonstrate higher activity of inflammatory processes (higher level of C-reactive protein, leptine) - that manifests in clinically more severe course of bronchopulmonary disease. Moleculary-genetic markers revealed are associated with higher activity of inflammation and therefore with increased risk of occupational bronchial asthma associated with metabolic syndrome and diabetess mellitus 2 type (polymorphisms of LEPR gene, IL-6 gene).

The article presents information on activities of International Committee on Occupational medicine - history of its foundation, development and formation, main scientific goals and studies.