The author presents results in main scientific trends developed in the Institute since its foundation and prospects of further advances in public health and healthcare, hygiene, industrial medicine, human ecology.

The authors accentuate the problem of preserving work potential of Russian population, most notable in industrial cities of Siberian federal district. Based on experience of Russian Federation outstanding scientists in industrial medicine and environmental hygiene (Izmerov N.F., Prokopenko L.V., At'kov O.Yu., Belyaev E.N., Bukhtiyarov I.V., Bushmanov A.Yu., Vereshagin A.I., Golovkova N.P., Kouz'mina L.P., Matiukhin VV., Tikhonova G.I., Ushakov I.B., et al), in accordance with Russian President's Orders and under support of Siberian Medical academic society, professionals in Research Institute of complex problems in hygiene and occupational diseases (Director - professor Zakharenkov VV.) carry out scientific basis for priority directions of governmental policy in Siberian region up to the level of complex special-purpose programs that are supposed to include present aims and facilities of various departments for implementation. The article covers conceptual points and main principles of program solutions, and one out of mechanisms for practical implementation.

Complex medical examination covered 87 metallurgists of aluminium production with chronic fluorine intoxication and 43 metallurgists witout occupational diseases, aged 40 to 60, to evaluate factors associated with multi-focal atherosclerosis risk in aluminium production workers with chronic fluorine intoxication. Findings are increased incidence of ischemic heart disease and combined atherosclerosis of extracranial and peripheral arteries in workers with long exposure to fluorine compounds. Metallurgists with chronic fluorine intoxication appeared to have more frequent hyperfibrinogenemia and coronary personality type A, if compared to those without occupational diseases.

The studies revealed specificity of morphologic changes in target organs, depending on acting occupational hazard. Evidences are that inhalation of coal rock dust causes irreversible sclerotic and degenerative changes mostly in lungs and bronchi even on 6th week of the experiment. In liver, changes in parenchyma and stroma are controlled by reparative processes by 9th week. Accumulation of sodium fluoride in the body causes irreversible necrotic changes mostly in liver, on 6th week of the intoxication. With that, morphologic changes in lungs and bronchi are minor, characterized by immune inflammation with degenerative changes only after the 9th week. Irrespective of the acting hazard, vascular changes are characterized by media and intima hypertrophy with endothelial dystrophy and hyalinosis since the 6th week of the experiment.

To design forecasting system, the authors studied occurrence of atherosclerosis and its risk factors in 152 workers of coal mines in South Kouzbass (tunnellers, cleaning pit-face miners, mining excavator operators), suffering from anthracosilicosis. Atherosclerosis was revealed in 124 (81.6%) workers with anthracosilicosis. With Bayess method for independent signs and Wald's sequential analysis method, the authors created a way to forecast atherosclerosis with coronary, extracranial and peripheral arteries involvement in miners with anthracosilicosis. Maximal risk of atherosclerosis in miners with anthracosilicosis is associated with following parameters: age 45 years and over, arterial hypertension, smoking, abdominal obesity type, diabetes mellitus, metabolic syndrome, respiratory failure, family history of IHD, hypercholesterolemia, increased LDL cholesterol, decreased HDL cholesterol, increased atherogeneity coefficient, hypertriglyceridemia, hyperhomocysteinemia, hyperfibrinogenemia, increased C-reactive protein, hypersthenic type according to Reese-Isenc index, andromorphic type according to Tanner index, blood group markers A (II) and B (III), rhesus negative, MN and NN. Through increased number of factors analyzed and selected additional markers, accuracy of atherosclerosis forecasting is increased - that enables to proceed with opportune treatment and prevention.

The authors studied intracellular liver protective mechanisms in development of chronic fluorine intoxication. Findings are that synthesis of protective proteins HIF-1a, HOx-1, HOx-2 and HSP72, restricting free radical oxidation in hepatocytes increased in liver at early stages (1-3 weeks) of exposure to fluorine. At late terms of chronic fluorine intoxication (6-12 weeks), damaging effects of fluorine result from its genotixicity - ability to suppress synthesis of intracellular protective proteins and enzymes of main metabolic cycles in liver.

Mining industry is characterized by hazardous work conditions that determine high risk of occupational morbidity. The article presents results of hygienic evaluation of work conditions and health risk for workers of Tashtagolsk mining enterprise in Kemerovo region, due to exposure to occupational hazards: noise, dust level, toxic chemicals. The authors present structure of occupational groups in mining industry, based on values of occupational factors, and taxonomic index characterizing overall risk level connected with occupational hazards.

The authors analyzed changes of statistic, spectral and non-linear parameters of cardiac rhythm variability in response to active orthostasis test in young individuals engaged into manual work, and the results are compared with hemodynamic parameters. Evidence is that the patients with neurogenous fainting present sympathetic vasomotory regulation disorders even in young age, before clinical manifestation as orthostatic hypotension. In comparison with common tilt-test, spectral analysis of cardiac rhythm variability in active orthostatic test can be more useful to reveal early disorders of autonomous regulation.

Experimental studies covered risk of possible toxic influence by medications - derivatives of 1.4-benzodiazepine - in single and multiple intake by intragastric way, inhalation and skin application. The authors give recommendations on hygienic regulation of 1.4-benzodiazepine derivatives - alprazolam, diazepam, mezapam and nozepam. The study results served as a base for specifying approximate safe level of exposure to alprazolam at level of 0.1 mg/m³, diazepam - 0.2 mg/m³, mezapam - 0.3 mg/m³ and nozepam at level of 1.0 mg/m³ in the air of workplace.

The article presents results of evaluating chronic intoxication risks, acute toxic effects risk, carcinogenic risk and risk of occupational diseases due to dust. Findings are that the highest risk levels for chronic intoxication and carciongenic risk are seen in coal open cast miners. The most dangerous occupation is diesel locomotive operator. High risk of occupational disease due to dust is seen in electric steel-making, rail and structural steel production. The most dangerous occupations are electric furnace melters, melter assistants, crane operators, hot rolling operators, metal heaters. The authors revealed chemicall pollutants making maximal contribution into formation of health risk for workers.

The article presents results on experimental modelling an influence of silver nanoparticles incorporated into natural polymer arabinogalactane matrix on brain tissue of white outbred rats. The rats underwent parenteral injection of silver nanoparticles incorporated into polymer arabinogalactane matrix (dosage of 100 and 500 micrograms of silver per kg of the animal weight). The studies covered expression of 2 proteins participating in apoptosis process, in mitochondrial activation type - сaspase-3 and protein bcl-2. During experiment, the groups examined demonstrated significant dose-dependent effect of bcl- 2 protein expression and increased number of caspase-3 expressed and non-expressed hyperchromic cells under exposure to argentumarabinogalactane - that indicates disorders of cellular structure and apoptosis development.

The article covers historical materials about Russian scientists Vladimir Vladimirovitch Svyatlovsky, author of the first Russian manual on industrial medicine - «Factory hygiene». Role of the scientist in national science development, his contribution into workers' health preservation, his works and lectures - these are topics also covered in the article.