The article studies structure of occupational morbidity in Russian Federation over recent years. According to WHO and WLO, leading role in occupation-related mortality structure is taken by occupational diseases among which respiratory diseases prevail.

The article presents a problem of safe usage of pesticides in agriculture production in Russian Federation. The authors describe value of Russian model of risk evaluation in a system of safe pesticides usage and its possible application as a probative basis to solve problems on possibility or prohibition of plants protection means in the country.

The authors suggested a new methodic approach to evaluation of dermal exposure to pesticides in workers, using biologic model for creation of exposed washout through placement of measured quantity of the studied substance and assessment of median washout completeness that enables complete evaluation of skin pollution. That justifies measures of individual primary prevention, priority of dermal way for toxicant entry, solutions on the medicine application in Russian Federation. The suggested priority method served as a base of patent «Method to evaluate dermal exposure to pesticides in workers».

Based on results of pesticides tests in natural conditions, the authors evaluated risk for operators working with acetochlorine pesticides according to expsure and absorbed dose, defined preparations with exposure risk more than the allowable one. The article presents data on specific formation of exposure to acetochlorine on operator's skin in real conditions of agricultural production. Findings are that the most intensive skin pollution with the substance is seen in first 20 minutes of work with pesticide. Formation of exposure levels of pesticides on skin and in workplace air depends on many environmental factors, work time, equipment used and preparation form contents.

The authors first performed comparative analysis of work conditions and workers' morbidity in implementation of economical production principles on transport machinery construction enterpirse. Since 2010 phased implementation of economical production principles in work safety enabled to decrease a share of 3.4 jeopardy class workplaces from 13.4% to 1.9%, that of 3.3 jeopardy class - from 47.3% to 20.6%, that was associated with reliable decrease in transitory disablement morbidity and occupational morbidity. Implementation of industrial systems based on economical production principle results in effective solving problems of safe work conditions in industry and eventually in lower morbidity of workers in the enterprise.

Present regulatory base determining examination procedure of relation between malignancies and work conditions forms two types of uncertainity: absence of data on development of nosologic variants of malignancies under influence of various carcinogens and nonregulated parameters of exposure characteristics that enable to conclude on probative measure of impact. For overcoming the current problems, the authors suggest to use data published by International Cancer study Agency and to apply methods of individual carcinogenic risk evaluation.

The authors defined features of hormone changes in pituitary-thyroid and pituitary-genital systems among workers of mining industry and machinery construction, having vibration disease, neurosensory deafness and association of several occupational diseases. Levels of thyroid-stimulating hormone, free triiodothyronine and free thyroxine change insignificantly. Only a tendency to higher level of thyroid-stimulating hormone and lower free triiodothyronine and free thyroxine is seen. Changes in hormones of pituitary-genital system are more intense. Concentration of luteinizing hormone considerably increases, and that of general testosterone - decreases. The hormonal changes are more marked in associated diseases and depend on the disease severity.

The authors performed retrospective analysis of occupational deafness morbidity in some major enterprises of mining industry and machinery construction over 20 years (1991-2012). Analysis covered archives of Erisman Clinic over 1988 2012. Findings are considerable increase in occupational deafness occurrence in enterprises engaged into mining and ore processing. Disclosed features of occupational deafness formation and course nowadays are: prevalence of early and light forms of the disease (70-84%), longer terms of development by 3.7-6.5 years in average, older age of the patients by 4-7 years at primary diagnosis (in comparison with 1990s).

The article covers characteristics of demographic processes in Irkutsk region over 2000-2012 and presents trends and specific changes in mortality, birth rate, average life expectancy, and influence of these changes on formation of children and able-bodied populations. Main losses of reproductive and woking potential of Irkutsk region population over 2000-2012 are caused by considerable population reduction (by 8,4%), major mortality of males at young age (mortality coefficients of males are 2,8-4,1 higher than those of the females), lower average life expectancy (the average life expectancy for the males is by 2,5-4,4 years lower than the average one in North Federal District and in Russian Federation, that for the females is by 1,5-3,1 years lower), decreased share of children (from 21,9 to 17,8%) and adolescent (from 5,6 to 3,4%) population, reduction of fertile female population (by 14.4%) and able-bodied population (by 9.4%). The observed positive trends in increased birth rate are insufficient for extended and simple reproduction of reproductive and working resources in descending generations.

Regulation should cover duration of physical work in heating microclimate, when physiologic thermoregulatory mechanisms fail to preserve heat balance in human body, manifesting in functional strain of many systems, with discomfort, health disorders, overheating of various degrees. Based on evaluation of heat and functional state of human wearing military combat outfit, the authors demonstrated that continuous physical work at air temperature +50C is permissible for 35-65 min, with preserved fighting efficiency, quality of tactical operations and health.