Influence of nonsteroid anti-inflammatory preparations on development of gastro-intestinal tract diseases: new possibilities of gastric and enteral protection (review of literature)
Abstract
Nonsteroid anti-inflammatory medicines are most widely used medicaments with pain-killing, anti-inflammatory and antipyretic action. Systematic intake of nonsteroid anti-inflammatory medicines frequently affect whole length of gastrointestinal tract, with erosions and ulcers formation, complicated by gastro-intestinal bleeding. Given systemic pain-killing action of nonsteroid anti-inflammatory medicines, these complications often are asymptomatic, being an accidental finding at endoscopic examination. Selective inhibitors intake does not rule out risk of gastric and intestinal problems due to nonsteroid anti-inflammatory medicines, thus prevention of those complications remain a topical problems nowadays. Special attention is paid to possible protection of gastric and intestinal lining. The authors listed major risk factors and complication types induced by nonsteroid anti-inflammatory medicines, considered main groups of medications used in treatment of those gastrointestinal disorders. Special accent is made on advantages of relatively new cytoprotector drug Rebamipid - at present single inductor of endogenous prostaglandine synthesis. Clinical data supporting its high efficiency and low incidence of adverse effects are presented.
Keywords
нестероидные противовоспалительные препараты,
побочные эффекты,
НПВП-гастро- и -энтеропатии,
факторы риска развития НПВП-гастропатий,
цитопротекторы,
ребамипид,
nonsteroid anti-inflammatory medicines,
side effects,
gastro- and enteropathies due to nonsteroid anti-inflammatory medicines,
risk factors of gastropathies due to nonsteroid anti-inflammatory medicines,
cytoprotectors,
rebamipid
About the Authors
S. A. Chorbinskaja
Central state medical academy of department of presidential affairs of the Russian Federation
Russian Federation
Russian Federation
N. A. Kudryavtseva
Central state medical academy of department of presidential affairs of the Russian Federation
Russian Federation
Russian Federation
G. A. Baryshnikova
Central state medical academy of department of presidential affairs of the Russian Federation
Russian Federation
Russian Federation
S. A. Davitashvili
«Hospital with polyclinic» of administrative Department of the President of the Russian Federation
Russian Federation
Russian Federation
I. I. Stepanova
Central state medical academy of department of presidential affairs of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Chorbinskaja S.A., Kudryavtseva N.A., Baryshnikova G.A., Davitashvili S.A., Stepanova I.I. Influence of nonsteroid anti-inflammatory preparations on development of gastro-intestinal tract diseases: new possibilities of gastric and enteral protection (review of literature). Russian Journal of Occupational Health and Industrial Ecology. 2017;(8):37-42. (In Russ.)
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