Evaluation of biologic effects caused by nano-silver influence on brain tissue of experimental animals
Abstract
The article presents results of histologic and immunohistochemical examination of nerve tissue of outbred white rats subjected over 9 days to nanobiocomposite containing nanoparticles of silver and natural biopolymer arabinogalactane. Exposure to the studied chemical was proved to cause structural and functional changes in nervous tissue. Comparing results of structural study of nervous tissue with expression of proteins caspase-3 and bcl-2 proves ability of nanosilver incapsulated into polymer matrix to penetrate through blood-brain barrier and induce apoptosis in neurons of brain cortex.
About the Authors
L. M. Sosedova
East-Siberian Institution of Medical and Ecological Research
Russian Federation
Russian Federation
M. A. Novikov
East-Siberian Institution of Medical and Ecological Research
Russian Federation
Russian Federation
E. A. Titov
East-Siberian Institution of Medical and Ecological Research
Russian Federation
Russian Federation
V. S. Rukavishnikov
East-Siberian Institution of Medical and Ecological Research
Russian Federation
Russian Federation
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Review
For citations:
Sosedova L.M., Novikov M.A., Titov E.A., Rukavishnikov V.S. Evaluation of biologic effects caused by nano-silver influence on brain tissue of experimental animals. Russian Journal of Occupational Health and Industrial Ecology. 2015;(4):26-30. (In Russ.)
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