Features of differential diagnosis of diseases with lung tissue dissemination syndrome in patients working in harmful and dangerous working conditions

The relevance of considering the issues of differential diagnosis of pulmonary dissemination syndrome in clinical practice is dictated by a similar X-ray picture in various clinical conditions. A thorough approach to the diagnosis of disseminated lung diseases in the examination of the association of diseases with professional activity involves a complete examination algorithm in order to exclude general somatic pathology and confirm the diagnosis with histological studies. A crucial factor for the recognition of a disease related to professional activity is the presence of long-term work experience in a profession with harmful working conditions in contact with dust, chemical factors exceeding the maximum permissible concentrations. The deciding factor for the recognition of a disease related to professional activity is the presence of long experience in a profession with harmful working conditions in contact with dust, chemical factors exceeding the maximum permissible concentrations.

This publication presents a clinical case of a patient in order to draw attention to the importance of dynamic monitoring of the patient, monitoring of examination data, including multispiral computed tomography of the chest organs in dynamics, a joint coordinated approach to the diagnosis of the disease according to a single algorithm of the occupational pathologist and general practitioners. The analysis of sanitary and hygienic characteristics, the results of the examination of related specialists in order to exclude a common somatic pathology similar in X-ray data, as well as dynamic monitoring will make it possible to correctly verify the diagnosis and start appropriate treatment in a timely manner.

Ethics. The article was approved by the Ethics Committee at the Novosibirsk Scientific Research Institute of Hygiene of Rospotrebnadzor (Protocol No. 5 dated September 2, 2025).

Contributions:
Ivashchenko I.E. — research concept and design, data collection and processing, text writing, editing;
Kuzmenko M.A. — research concept and design, text writing, editing;
Alexandrova I.V. — research concept and design, data processing;
Miller O.Yu. — data collection and analysis;
Alekhno A.S. — data collection, analysis, editing.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 23.09.2025 / Accepted: 27.10.2025 / Published: 21.11.2025

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