The state of lipid metabolism indicators and the system of peroxidation — antioxidant protection in aluminum production workers with occupational bronchopulmonary pathology
https://doi.org/10.31089/1026-9428-2023-63-9-605-610
EDN: fayswf
Abstract
Introduction. In aluminum production workers, the most common occupational pathology is bronchopulmonary diseases, which are characterized by the formation of comorbid pathologies. Oxidative stress plays a key role in the pathogenesis of bronchopulmonary and cardiovascular pathologies.
The study aims to research the indicators of oxidative metabolism and antioxidant protection in aluminum production workers with occupational bronchopulmonary pathology (OBPP) during work and post-contact period.
Materials and methods. During the study, on the basis of the therapeutic department of the clinic at East-Siberian Institute of Medical and Ecological Research, scientists examined 130 patients — workers of aluminum production, with an established professional diagnosis of the bronchopulmonary system both during work and in the post-contact period. The authors have analyzed the indicators of oxidative stress, lipid metabolism and the concentration of antibodies to oxidized low-density lipoproteins.
Results. In patients with OBPP, decreased superoxide dismutase activity was more common during work than in the post-exposure period. About 60% of the examined patients had elevated cholesterol levels, almost 40% had higher reference values of the atherogenicity index and the content of antibodies to oxidized low-density lipoproteins. Cholesterol levels in high-density lipoproteins in individuals with OBPP in the long-term period were lower than in individuals with the same pathology during the work period.
Conclusion. The depletion of antioxidant protection in workers in the post-contact period of the OBPP, the researchers noted in the form of a decrease in the activity of superoxide dismutase in every third person examined, which can lead to the formation of endothelial dysfunction. An increase in the fractions of atherogenic cholesterol is accompanied by a significant increase in the occurrence of a reduced level of high-density lipoprotein cholesterol, which has anti-atherogenic properties.
Ethics. The examination of patients met ethical standards in accordance with the Helsinki Declaration of the World Association "Ethical Principles of Conducting Scientific Medical Research with Human Participation", as amended in 2000 and the "Rules of Clinical Practice in the Russian Federation", approved by Order of the Ministry of Health of the Russian Federation No. 266 of 06/19/2003. All the surveyed signed an informed consent to participate in the study. The protocol of the study was approved by the Ethics Committee of the East Siberian Institute of Medical and Environmental Research (Protocol No. 6 of 10.03.2020).
Contribution:
Beigel E.A. — concept and design of the study, design and editing of the article, responsibility for the integrity of the article;
Kudaeva I.V. — concept and design of the study, collection and processing of the material, editing of the article, approval of the final version of the article;
Masnavieva L.B. — collection and processing of the material.
Funding. The work was carried out within the framework of the State task.
Conflict of interests. The author declares no conflict of interests.
Received: 25.08.2023 / Accepted: 04.09.2023 / Published: 05.10.2023
About the Authors
Elena A. Beigel
East-Siberian Institute of Medical and Ecological Research; Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of the Russian Medical Academy of Continuing Professional Education
Russian Federation
Deputy Chief Medical Officer at the East Siberian Institute of Medical and Environmental Research, Cand. of Sci. (Med.).
Russian Federation
Deputy Chief Medical Officer at the East Siberian Institute of Medical and Environmental Research, Cand. of Sci. (Med.).
E-mail: elena-abramatec@rambler.ru
Irina V. Kudaeva
East-Siberian Institute of Medical and Ecological Research
Russian Federation
Russian Federation
Ludmila B. Masnavievа
East-Siberian Institute of Medical and Ecological Research
Russian Federation
Russian Federation
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Review
For citations:
Beigel E.A., Kudaeva I.V., Masnavievа L.B. The state of lipid metabolism indicators and the system of peroxidation — antioxidant protection in aluminum production workers with occupational bronchopulmonary pathology. Russian Journal of Occupational Health and Industrial Ecology. 2023;63(9):605-610. (In Russ.) https://doi.org/10.31089/1026-9428-2023-63-9-605-610. EDN: fayswf
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