Modern aspects of professional cancer treatment: prospects for the use of medical ozone in the correction of free radical homeostasis

Introduction. The well-known features of oncogenesis make it possible to assume the prospects of medical ozone as part of a comprehensive health-saving therapy for professional oncopathologies. Due to the risk of stimulating the proliferation of tumor cells, research on the search for optimal modes of ozone exposure is relevant.

The aim of the study was to evaluate the possibility of using ozonated saline solution (OSS) as part of complex antitumor therapy in an experiment.

Materials and methods. The effect of OSS with different concentrations of ozone in the ozone-oxygen mixture on the content of hemoglobin, active products of thiobarbituric acid (TBA) of lipid peroxidation (LP), the degree of oxidative modification of proteins, and the activity of superoxide dismutase and catalase in blood, liver, spleen, and tumor tissues was studied in Mature rats with normal and transplanted cholangiocellular carcinoma.

Results. The course effect of the OSS did not have statistically significant changes in the studied biochemical parameters under the conditions of the physiological norm in the experiment. Exposure to OSS during oncogenesis led to a decrease in the content of TBA-active LP products in the liver by more than 30%.

Conclusions. Course exposure to OSS with an ozone concentration in an ozone-oxygen mixture of 400 micrograms/l may be promising for the correction of free radical homeostasis as part of complex antitumor therapy, including in oncogenesis due to occupational factors.

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