Clinical and genetic features of the formation of concomitant visceral pathology in workers with industrial fluorosis

Introduction. The urgency of the problem determines the high level of occupational morbidity in aluminum production workers and the prevalence of somatic pathology, which occupies one of the leading positions in the pathogenesis of fluorosis.

The aim of the study is to determine the clinical and genetic features of the nature of concomitant visceral pathology in workers with industrial fluorosis.

Materials and methods. A complex of clinical, biochemical, molecular, genetic, and instrumental research methods was used in patients with fluorosis (246 people) and in the control group (106 people).

Results. A high frequency of health disorders in workers engaged in the production of aluminum was determined during long-term monitoring. An extended clinical and genetic study of the state of somatic organs in workers with fluorosis and in control is presented. It is revealed that in the group of subjects with proven diagnosis, pathologies concomitant with the main disease were significantly more common: pathologies of musculoskeletal and articular systems, blood circulation, respiratory (rhinitis, chronic, toxic and dust-borne bronchitis, chronic obstructive pulmonary disease), hepatobiliary (steatosis, fluoride hepatopathy), gastrointestinal tract (chronic gastritis, cholecystopancreatitis), renal systems (pyelonephritis, urolithiasis), as well as a combination of several nosologies was in 43%. The association of GG VEGF genotypes with chronic pyelonephritis and TT Il1ß, GSTT 1 0/0 with fluoride hepatosis was revealed in patients with fluorosis.

Conclusions. The structure of occupational morbidity in workers of the main professions of aluminum production is dominated by concomitant pathology of functional systems against the background of bone destruction, determined by endogenous factors of the course of metabolic processes of the body.

The authors declare no conflict of interests.

1. Chebotarev A.G., Prokhorov V.A. Modern working conditions and occupational morbidity of metallurgists. Med. truda i prom. ekol. 2012; (6): 1-7 (in Russian).

2. Roslaya N.A., Likhacheva E.I., Oransky I.E., Odinokaya V.A., Plotko E.G., Zhovtyak E.P. et al. Clinical and pathogenetic features of chronic occupational toxicity with fl uorine compounds in modern conditions. Med. truda i prom. ekol. 2012; (11): 17-22 (in Russian).

3. Cicek E., Aydin G., Akdogan M. Effects of chronic ingestion of sodium fluoride on myocardium in a second generation of rats. Hum. Exp. Toxicol. 2005; 24(2): 79-87.

4. Hewavithana P.B., Jayawardhane W.M., Gamage R., Goonaratna C. Skeletal fluorosis in Vavuniya District: an observational study. Ceylon Med. J. 2018; 63(3): 139-42.

5. Obukhova T.Yu., Budkar L.N., Shmonina O.G., Ovchinnikova E.E., Talankina A.A., Kudrina K.S. The impact of cardiovascular and metabolic disease at the time of development of occupational chronic fluoride intoxication in workers of aluminium production. Ural’skiy meditsinskiy zhurnal. 2018; (10): 66-71 (in Russian).

6. Shalina T.I., Nikolaeva L.A., Savchenkov M.F., Bykov Yu.N., Manueva R.S. Environmental pollution by fluoride compounds and their effect on children’s health. Gigiyena i sanitariya. 2016; 95(12): 1133-7 (in Russian).

7. Kurchevenko S.I., Boklachenko E.V., Bodienkova G.M. Comparative analysis of the immune response in workers under the influence of various production factors. Gigiyena i sanitariya. 2018; 97(10): 905-9 (in Russian).

8. Zemlyanova M.A., Koldibekova Yu.V., Pustovalova O.V. Evaluation of the impact of work experience on biochemical and hematological parameters in fluoropolymer production workers. Med. truda i prom. ekol. 2017; (11): 24-30 (in Russian).

9. Zhukova A.G., Mikhailova N.N., Kazitskaya A.S., Alekhina D.A. Contemporary concepts of molecular mechanisms of the physiological and toxic effects of fluorine compounds on an organism. Meditsina v Kuzbasse. 2017; 16(3): 4-11 (in Russian).

10. Agalakova N.I., Petrova T.I., Gusev G.P. Activation of fas receptors, caspase-8 and caspase-3 by fluorine ions in rat red blood cells in vitro. Zhurnal evolyutsionnoy biokhimii i fiziologii. 2019; 55(2): 90-6 (in Russian).

11. Hassan H.A., Yousef M.I. Mitigating effects of antioxidant properties of black berry juice on sodium fluoride induced hepatotoxicity and oxidative stress in rats. Food Chem. Toxicol. 2009; 47(9): 2332-7.

12. Pan X., Yan W., Qiu B., Liao Y., Liao Y., Wu S. et al. Aberrant DNA methylation of Cyclind-CDK4-p21 is associated with chronic fluoride poisoning. Chem Biol Interact. 2019; (315): 108875.

13. Wang J., Yang J., Cheng X., Xiao R., Zhao Y., Xu H. et al. Calcium Alleviates Fluoride-Induced Bone Damage by Inhibiting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction. J Agric Food Chem. 2019; 67(39): 10832-43.

14. Nadey O.V., Sokolova T.V., Agalakova N.I. The effect of fluoride ions on rat cortex neurons. Morphology. 2019; 155(2): 209 (in Russian).

15. Obukhova T.Yu., Budkar L.N., Tereshina L.G., Karpova E.A. Dissociation of disorders of carbohydrate and lipid metabolism in workers in aluminum production according to a medical examination. Gigiyena i sanitariya. 2015; 94(2): 67-9 (in Russian).

16. Yadykina T.K., Zhukova A.G., Ulanova E.V., Kizichenko N.V., Scherbakova D.A., Bugaeva M.S. Functional and metabolic response of the hepatobiliary system to fluoride intoxication (experimental studies). Byulleten’ VSNC SO RA MN. 2010; (4): 64-8 (in Russian).

17. Panev N.I., Korotenko O.Yu., Filimonov S.N., Semenova E.A., Panev R.N. The prevalence of cardiovascular disease in workers in the aluminum industry. Gigiyena i sanitariya. 2019; 98(3): 276-9 (in Russian).

18. Mikhailova N.N., Yadykina T.K., Bugaeva M.S., Danilov I.P., Semenova E.A., Doroshilova A.V. et al. Clinical and experimental studies of the state of bone tissue with fluorosis. Med. truda i prom. ekol. 2019; (6): 364-370 (in Russian).

19. Ulanova E.V., Anokhina A.S., Danilov I.P., Gorbunova I.V., Gerasimova G.A. The use of nutraceuticals as a prophylaxis of occupational fluorosis. Med. truda i prom. ekol. 2006; (6): 44-8 (in Russian)

20. Bakumov P.A., Zernyukova E.A., Kozyrenko Yu.V., Kovalskaya E.N., Kochetova E.I. The influence of occupational factors on the digestive system. Lekarstvennyy vestnik. 2017; 11(2) (66): 40-51 (in Russian).

21. Budkar L.N., Obukhova T.Yu., Solodushkin S.I., Shmonina O.G., Kudrina K.S., Karpova E.A. et al. Development of chronic kidney disease in aluminum workers. Profilakticheskaya meditsina. 2019; 22(4-2): 30-4 (in Russian).

22. Partanen S. Inhibition of human renal acid phosphatases by nephrotoxic micromolar concentrations of fluoride. Exp Toxicol Pathol. 2002; 54(3): 231-7.

23. Yadykina T.K., Gorokhova L.G., Korsakova T.G. Partial kidney function and water-salt balance in experimental fluorosis. Мeditsina v Kuzbasse. 2017; 16(1): 57-63 (in Russian).

24. Petrenko O.D. The prevalence of skin diseases among workers in the electrolysis of nickel and aluminum. Ekologiya cheloveka. 2008; (10): 37-9 (in Russian).

25. Ufimtseva M.A., Bochkarev Yu.M., Struin N.L., Beresneva T.A., Sorokina K.N., Simonova N.V. Analysis of the results of a periodic medical examination by a dermatovenerologist of workers employed in metallurgical enterprises of the Sverdlovsk region. Zdorov’ye naseleniya i sreda obitaniya. 2018; 12(309): 19-23 (in Russian).

26. Bodienkova G.M., Boklazhenko E.V., Ushakova O.V. Immunoregulatory markers of bronchopulmonary pathology in workers in the aluminum industry. Meditsina truda i promyshlennaya ekologiya. 2018; (9): 29-34 (in Russian).

27. Beigel E.A., Katamanova E.V., Shayakhmetov S.F., Ushakova O.V., Pavlenko N.A., Kuks A.N., et al. The effect of prolonged exposure to industrial aerosols on the functional state of the bronchopulmonary system in workers in aluminum production. Gigiyena i sanitariya. 2016; (12): 1160-3 (in Russian).

28. Morozova V.V. The influence of adverse environmental factors on the example of fluoride compounds on the processes of pneumatization of the frontal sinuses. Sovremennyye problemy nauki i obrazovaniya. 2019; (4): 17 (in Russian).

29. Hayes J.D., Strange R.C. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology. 2000; 61(3): 154-66.