Antioxidant status of blood in patients with vibration disease
https://doi.org/10.31089/1026-9428-2019-59-12-978-982
Abstract
Introduction. The overwhelming number of publications contains only data on the content of individual antioxidants, but not on the overall antioxidant activity of the blood in patients with vibration disease.
The aim of the study was to determine the total antioxidant activity of blood serum in patients with vibration disease.
Materials and methods. Th e main group consisted of 30 people diagnosed with “Vibration disease” of 1 degree (n=21) and 2 degrees (n=9). Th e control group consisted of 30 clinically healthy men, comparable in age with the main group (p=0.66). Th e total activity of antioxidant systems of blood plasma was evaluated photometrically using the test system “Total antioxidant status-Novo” (“Vector-best”, Russia).
Results. The indicator of the total antioxidant status (TAS) was 1,038±0.232 mmol/l in the examined main group, against 1,456±0.225 mmol/l in the examined control group (p<0.000001). Th e coefficient of variation (CV) in patients with vibration disease was 22.35%, 1.45 times higher than in the control group (15.45%). In the main group there was a positive correlation between age and TAS (R=0.525), in the control group there was no such relationship (R=0.095). Th e degree of decrease depended on the severity of vibration disease.
Conclusions. 1. The development of vibration disease is accompanied by a decrease in the antioxidant status of blood serum. 2. Th e degree of decrease in the antioxidant status of blood serum correlates with the severity of vibration disease. 3. Reduction of TAS can serve as a pathogenetic justification of the need to include drugs and/or biologically active additives with antioxidant activity in therapy
About the Authors
N. N. Malyutina
Vagner Perm Federal State Medical University
Russian Federation
26, Petropavlovskaja str., Perm, Russia, 614990
Russian Federation
26, Petropavlovskaja str., Perm, Russia, 614990
A. F. Bolotova
Vagner Perm Federal State Medical University
Russian Federation
26, Petropavlovskaja str., Perm, Russia, 614990
Russian Federation
26, Petropavlovskaja str., Perm, Russia, 614990
R. B. Eremeev
Vagner Perm Federal State Medical University
Russian Federation
26, Petropavlovskaja str., Perm, Russia, 614990
Russian Federation
26, Petropavlovskaja str., Perm, Russia, 614990
A. Zh. Gilmanov
Bashkir Federal State Medical University
Russian Federation
3, Lenina str., Ufa, Russia, 450008
Russian Federation
3, Lenina str., Ufa, Russia, 450008
D. Yu. Sosnin
Vagner Perm Federal State Medical University
Russian Federation
Russian Federation
For correspondence: Dmitry Yu. Sosnin, professor of department of faculty therapy No. 2 of occupational diseases and
clinical laboratory diagnostics, Dr. of Sci. (Med.)
26, Petropavlovskaja str., Perm, Russia, 614990
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Review
For citations:
Malyutina N.N., Bolotova A.F., Eremeev R.B., Gilmanov A.Zh., Sosnin D.Yu. Antioxidant status of blood in patients with vibration disease. Russian Journal of Occupational Health and Industrial Ecology. 2019;(12):978-982. (In Russ.) https://doi.org/10.31089/1026-9428-2019-59-12-978-982
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