Indicators of the relationship between heart rate variability and levels of glycemia and cholesterol in vibration pathology

Introduction. Vibration disease (VD) is one of the leaders in the structure of occupational diseases among workers in the coal mining industry. The occurrence of disorders at the systemic level (primarily in the nervous and vascular systems) leads to suppression of heart rate variability (HRV) in vibration pathology as a result of damage to vegetative fi bers, centers, ganglia. The study of metabolic disorders in relation to HRV indicators, including nonlinear ones, is of interest for understanding the mechanisms of the VD, and is also important for fi nding non-invasive and less expensive methods of dynamic control.

The aim of the study was to study the parameters of heart rate variability, total cholesterol and blood glucose levels in patients with vibration disease, to identify the relationship between them.

Materials and methods. 75 patients of the Clinic of the Research Institute for Complex Problems of Hygiene and Occupational Diseases subjected to industrial vibration for 10 years or more (the main group) and 20 people of the control group who never had contact with industrial vibration were examined. Th e age of the subjects was 40–60 years. Fasting blood glucose and total cholesterol levels were studied, heart rate variability was studied. Frequency and nonlinear phenomena of heart rate variability were analyzed. Spearman correlation coeffi  cient was determined to assess the strength of the relationship between blood and heart rate variability.

Results. Glucose and cholesterol levels were statistically higher in the group of patients with vibration disease. Spectral parameters of high — and low-frequency heart rate variability in the main group signifi cantly decreased. In patients with vibration pathology of the approximated entropy was signifi cantly lower, whereas deranty fl uctuation analysis increased. Th ese changes of heart rate variability indicate the involvement of all departments of vegetative nervous system, the development of relative sympathicotonia. Correlations of average strength between heart rate variability and levels of glycemia and cholesterol were revealed.

Conclusion. Under the infl uence of industrial vibration in workers’ blood cholesterol and glucose levels increase, heart rate variability is suppressed and correlated with an increase in metabolic disorders. 

1. Artamonova V.G., Kolesova E.B., Kuskova L.V. Some modern aspects of the pathogenesis of vibration disease. Med. truda i prom. ekol. 1999; (2): 1–3 (in Russian).

2. Kiryakov V.A., Pavlovskaya N.A., Lapko I.V., Bogatyreva I.A., Antoshina L.I., Oshkoderov O.A. Impact of occupational vibration on molecular and cell level of human body. Med. truda i prom. ekol. 2018; (9): 34–43 (in Russian).

3. Kuzmina O.Y. Clinical and epidemiological features of the metabolic syndrome in patients with occupational diseases. Mezhdunarodnyy endokrinologicheskiy zhurnal. 2011; (4): 154–60 (in Russian).

4. Panacheva L.A., Platonova E.A., Kuznetsova G.V. Prevalence and clinical manifestations of metabolic syndrome in vibration disease. Med. truda i prom. ekol. 2011; (10): 36–9 (in Russian).

5. Lapko I.V., Kir’yakov V.A., Pavlovskaya N.A., Antoshina L.I., Oshkoderov O.A. Infl uence of occupational vibration on development of resistance to insuline and of II type diabetes mellitus. Med. truda i prom. ekol. 2017; (2): 30–3 (in Russian).

6. Gemne G. Pathophysiology of white fi ngers in workers using hand-held vibration tools. Nagoya J. Med. Sci. 1994; 57(5): 87–97.

7. Mironova T.F., Davydova E.V., Utochkina I.M., Kalmykova A.V., Sokolova T.A. Clinical analysis of heart rate variability in occupational diseases. Vestnik Chelyabinskoy oblastnoy klinicheskoy bol’nitsy. 2012; (1): 20–4 (in Russian).

8. Melentev A.V., Serebryakov P.V., Zheglova A.V. Infl uence of noise and vibration on nervous regulation of heart. Meditsina truda i promyshlennaya ekologiya. 2018; (9): 19–23 (in Russian).

9. Francis D.P., Willson К., Georgiadou P., Wensel R., Davies L.C., Coats A. et al. Physiological basis of fractal complexity properties of heart rate variability in man. J. Physiol. 2002; 542 (Pt 2): 619–29.

10. Manilo L.A., Zozulya E.P. Automatic recognition of atrial fi brillation via estimation of approximated entropy. Informatsionnoupravlyayushchie sistemy. 2006; (1): 21–7 (in Russian).

11. Fleishman A.N., Korablina T.V., Smagina E.S., Petrovskiy S.A., Ioven D.E., Neretin A.A. Entropy and DFA of heart rate variability in remote ischemic preconditioning, orthostatic test in healthy young subjects and in individuals with changes in autonomic regulation of cardiodynamics. Izvestiya vysshikh uchebnykh zavedeniy. Prikladnaya nelineynaya dinamika. 2016; 24(5): 37–61 (in Russian).

12. Boulton A.J.M., Vinik A.I., Arezzo J.C., Bril V., Feldman E.L., Freeman R. et al. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005; 28(4): 956–62.

13. Millis R.M., Austin R.E., Hatcher M.D., Bond V., Goring K.L. Metabolic energy correlates of heart rate variability spectral power associated with a 900-calorie challenge. J. Nutr. Metab. 2011; 2011: 715361. DOI: 10.1155/2011/715361.

14. Liao D., Sloan R.P., Cascio W.E., Folsom A.R., Liese A., Evans G.W. et al. Multiple metabolic syndrome is associated with lower heart rate variability: Th e atherosclerosis risk in communities study. Diabetes Care. 1998; 21(12): 2116–22.

15. Severeyn E., Wong S., Passariello G., Cevallos J.L., Almeida D. Methodology for the study of metabolic syndrome by heart rate variability and insulin sensitivity. Rev. Bras. Eng. Bioméd. 2012; 28(3): 272–7.

16. Raimundo R.D., Godleski J.J. Heart rate variability in metabolic syndrome. Journal of Human Growth and Development. 2015; 25(1): 7–10. DOI: 10.7322/jhgd. 96757.

17. Doncheva N.I., Nikolova R.I., Danev S.G. Overweight, dyslipoproteinemia, and heart rate variability measures. Folia Med. (Plovdiv). 2003; 45(1): 8–12.

18. Kratnov A.E., Yakimova A.V., Silkina E.E. Heart rate variability in male patients with metabolic syndrome. Sakharnyy diabet. 2013; (1): 15–18 (in Russian).

19. Khurs E.M., Andreev P.V., Poddubnaya A.V., Evsina M.G., Smolenskaya O.G. Heart rate variability in patients with metabolic syndrome: 24-hour ECG monitoring data. Rossiyskiy kardiologicheskiy zhurnal. 2010; (2): 18–21 (in Russian).

20. Novikova D.S., Popkova T.V., Gerasimov A.N., Volkov A.V., Nasonov E.L. Association between heart rate variability and the components of the metabolic syndrome in women with rheumatoid arthritis. Ratsional’naya farmakoterapiya v kardiologii. 2014; 10 (1): 18–24 (in Russian).