Analysis of cell death indicators in employees under exposure to phenol at work
https://doi.org/10.31089/1026-9428-2018-10-62-64
Abstract
For early diagnosis of health disorders in workers exposed to excessive levels of phenol, the authors identified parameters of immune state, characterizing apoptosis of immune cells. The identification used contemporary method of laboratory immunologic studies including flow cytometry. Findings are that biologic media highly contaminated with phenol demonstrate statistically significant (twice; p < 0.05) decrease of transcription factor p53 expression and TNFRI cells count, as well as 1.2 times lower percentage of apoptosis-associated Annexin V-FITC+7-AAD- cells — that characterizes a course of cell death as its inhibition by apoptosis mechanism. Phenol-containing compounds when continuously incorporated into workers’ bodies transform components of cellular signal pathways and by changing ratio between pro-apoptotic and contra-apoptotic intracellular signals negatively modify survival of cells in carcinogenesis and form potential danger of malignancies.
About the Authors
Dina G. Dianova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Russian Federation
82, Monastyrskaya Str., Perm, 614045
Russian Federation
82, Monastyrskaya Str., Perm, 614045
Oleg V. Dolgikh
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Russian Federation
82, Monastyrskaya Str., Perm, 614045
Russian Federation
82, Monastyrskaya Str., Perm, 614045
Inga N. Alikina
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Russian Federation
82, Monastyrskaya Str., Perm, 614045
Russian Federation
82, Monastyrskaya Str., Perm, 614045
Yuliya A. Chelakova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Russian Federation
82, Monastyrskaya Str., Perm, 614045
Russian Federation
82, Monastyrskaya Str., Perm, 614045
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Review
For citations:
Dianova D.G., Dolgikh O.V., Alikina I.N., Chelakova Yu.A. Analysis of cell death indicators in employees under exposure to phenol at work. Russian Journal of Occupational Health and Industrial Ecology. 2018;(10):62-64. (In Russ.) https://doi.org/10.31089/1026-9428-2018-10-62-64
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