Genotoxic effect of some elemental or element oxide nanoparticles and its diminution by bioprotectors cоmbination
Marina P. Sutunkova,
Oleg G. Makeyev,
Larisa I. Privalova,
Il’zira A. Minigaliyeva,
Vladimir B. Gurvich,
Svetlana N. Solov’yova,
Svetlana V. Klinova,
Vadim O. Ruzakov,
Artyom V. Korotkov,
Evgeniy A. Shuman,
Boris A. Katsnelson https://doi.org/10.31089/1026-9428-2018-11-10-16
Abstract
Random Amplification of Polymorphic DNA (RPD) analysis was a part of toxicological studies to determine DNA fragmentation coefficient (Kfr) after the exposure to nanoparticles of silver, gold, copper oxides, iron, aluminum, zinc, lead, nickel, silicon administered intraperitoneally or by inhalation.
Intraperitoneal administration occurred 3 times a week for 6 weeks and covered empirically selected sublethal doses to provide moderate intoxication. Inhalational expositions continued 4 hours a day 5 times a week for 3, 6 or 10 months. The statistically significant increase in nuclear DNA fragmentation was observed in all cases of exposure to nanoparticles. If subjected to a combination of bioprotectors varying in the action mode, genotoxicity of the silver, copper oxide and nickel oxide nanoparticles was significantly weaker.
About the Authors
Marina P. Sutunkova
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Oleg G. Makeyev
Ural State Medical University
Russian Federation
3, Repina Str., Ekaterinburg, 620028
Russian Federation
3, Repina Str., Ekaterinburg, 620028
Larisa I. Privalova
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Il’zira A. Minigaliyeva
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Vladimir B. Gurvich
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Svetlana N. Solov’yova
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Svetlana V. Klinova
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Vadim O. Ruzakov
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Artyom V. Korotkov
Ural State Medical University
Russian Federation
3, Repina Str., Ekaterinburg, 620028
Russian Federation
3, Repina Str., Ekaterinburg, 620028
Evgeniy A. Shuman
Ural State Medical University
Russian Federation
3, Repina Str., Ekaterinburg, 620028
Russian Federation
3, Repina Str., Ekaterinburg, 620028
Boris A. Katsnelson
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers
Russian Federation
30, Popova Str., Ekaterinburg, 620014
Russian Federation
30, Popova Str., Ekaterinburg, 620014
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Review
For citations:
Sutunkova M.P., Makeyev O.G., Privalova L.I., Minigaliyeva I.A., Gurvich V.B., Solov’yova S.N., Klinova S.V., Ruzakov V.O., Korotkov A.V., Shuman E.A., Katsnelson B.A. Genotoxic effect of some elemental or element oxide nanoparticles and its diminution by bioprotectors cоmbination. Russian Journal of Occupational Health and Industrial Ecology. 2018;(11):10-16. (In Russ.) https://doi.org/10.31089/1026-9428-2018-11-10-16
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