Influence of occupational hazards on human immune state
Abstract
Experiments helped to study features of human immune reactivity to long action of occupational hazards - coal stock dust and fluorine compounds. Findings are that coal stock dust inhalation causes activation of urgent adaptation elements at early stage, but by 6th week of the experiment - chronization of inflammatory process. Fluorine excess, due to its high reactivity, causes mostly toxic effects, early expression of anti-inflammatory cytokines and delayed anti-inflammatory immune response. Main immunologic markers of anthracosilicosis and fluorosis development risk are revealed.
About the Authors
V. V. Zakharenkov
Institute for Complex Problems of Hygiene and Occupational Diseases
Russian Federation
Russian Federation
A. S. Kazitskaya
Institute for Complex Problems of Hygiene and Occupational Diseases
Russian Federation
Russian Federation
N. N. Mikhailova
Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk branch of Kemerovo State University
Russian Federation
Russian Federation
D. V. Romanenko
Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk branch of Kemerovo State University
Russian Federation
Russian Federation
N. N. Zhdanova
Institute for Complex Problems of Hygiene and Occupational Diseases
Russian Federation
Russian Federation
A. G. Zhukova
Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk branch of Kemerovo State University
Russian Federation
Russian Federation
References
1. Величковский Б.Т. // Вестн. РАМН. - 2001. - № 6. - С. 45-52
2. Гусев Е.Ю., Черешнев В.А. // Патол. физиол. - 2013. - № 3. - С. 3-14.
3. Захаренков В.В., Михайлова Н.Н., Горохова Л.Г. и др. // Способ моделирования антракосиликоза. - Патент № 2534872 от 07.10.2014 г.
4. Измеров Н.Ф., Бухтияров И.В., Прокопенко Л.В. и др. // Мед. труда и пром. экология. - 2012. - № 11. - С. 1-7.
5. Косарев В.В., Жестков А.В., Бабанов С.А. и др. // Мед. труда и пром. экология. - 2012. - № 9. - С. 22-27.
6. Михайлова Н.Н., Сазонтова Т.Г., Алехина Д.А. и др. // Цитокины и воспаление. - 2013. - № 4. - С. 71-76.
7. Михайлова Н.Н., Уланова Н.Н., Фоменко Д.В. и др. // Способ профилактики хронической фтористой остеопатии при моделировании фтористой интоксикации в эксперименте. - Патент № 2300374 от 10.06.2007 г.
8. Оськина И.Н., Гербек Ю.Э., Шихевич С.Г. и др. // Вестн. ВОГиС. - 2008. - Т. 12, № 1/2. - С. 39-49.
9. Симбирцев А.С. // Цитокины и воспаление. - 2004. - Т. 3, № 2. - С. 16-22.
10. Zhukova A.G., Alekhina D.A., Sazontova T.G. et al. // Bull. Exp. Biol. Med. - 2013. - 156 (2). P. 224-227.
11. Zakharenkov VV., Mikhailova N.N., Zhdanova N.N. et al. // Bull. Exp. Biol. Med. - 2015. - 159 (4). - P. 431-434.
Review
For citations:
Zakharenkov V.V., Kazitskaya A.S., Mikhailova N.N., Romanenko D.V., Zhdanova N.N., Zhukova A.G. Influence of occupational hazards on human immune state. Russian Journal of Occupational Health and Industrial Ecology. 2017;(12):19-23. (In Russ.)
Views:
444
Email this article 
