Genetic features of workers with age-related arterial hypertension (exemplified by titanium magnesium production)

Opicality of the study is based on importance of genetic markers isolation to use them as indicators of arterial hypertension development in accordance with age of titanium manganese production workers. Analysis of single-nucleotide polymorphisms frequency in sites of 20 candidate genes was done with real-time polymerase chain reaction, with results assessment by allel discrimination method. Findings are that age over 40 is a modifier that has statistically significant (p<0,05) influence on disease development in the sample without genetic background consideration (OR = 3,781). Allel variants of 1^st and 2^nd phases of detoxification, nervous regulation and carbohydrate metabolism were specified - ANKK (rs1800497), SULT1A1 (rs9282861), NR3C1 (rs6195) and CYP1A1 (rs1048943) - most frequent in arterial hypertension. The cause-effect relationship between arterial hypertension and age over 40 is reliably significant in heterozygotes in ANKK (OR = 10,357) and SULT1A1 (OR = 6,462) genes, and in homozygotes of wild type in NR3C1 (OR = 4,444) and CYP1A1 (OR = 5,556). Variant allels of candidate genes ANKK (rs1800497), SULT1A1 (rs9282861), NR3C1 (rs6195), CYP1A1 (rs1048943) characterize features of arterial hypertension development, if associated with age of magnesium production workers, and are recommended as markers for decisions on lower exposure to hazardous work conditions.

вредные условия труда, полиморфизм гена рецептора дофамина, полиморфизм гена фенолсульфотрансферазы, полиморфизм гена цитохрома, полиморфизм гена рецептора глюкокортикоидов, hazardous work conditions, polymorphism of dophamine gene receptor, polymorphism of phenol sulfotransferase gene, polymorphism of cytochrome gene, polymorphism of glucocorticoids receptor gene

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