Combined subchronic toxicity of nickel and manganese oxides nanoparticles, and its decrease due to bioprotectors complex
Abstract
Stable suspensions of NiO and/or Mn3O4 nanoparticles with average diameter 16,7±8,2 nm and 18,4±5,4 nm respectively, obtained via laser ablation of the metals with 99,99% purification in deionized water, were injected intraperitoneally into rats in dose of 0,5 mg or 0,25 mg three times per week up to 18 times separately or in various dose combinations. A group of rats received combined injections of nanoparticles in the highest dose or merely water with oral «bioprotector complex» containing pectin, vitamins A, C and E, glutamate, glycine, N-acetylcysteine, selenium, iodine and polyunsaturated fatty acids of omega-3 class. Intoxication development was assessed through multiple functional parameters and histologic changes in liver, spleen, kidneys and brain. Nickel and manganese accumulation in these organs was measured via various methods. Both types of metallic oxide nanoparticles appeared to be hazardous for body, but Mn3O4 caused more harm according to major nonspecific toxicity manifestations. Moreover, they caused more intense injury to caudate nucleus and hippocamp neurons - that can be considered as an experimental model of manganese parkinsonism. Mathematic analysis based on response pattern revealed ambiguity of the combined toxicity type, depending on the effects assessed and on its level. Due to the bioprotector complex, organic and systemic toxicity and genotoxicity of Mn3O4 and NiO nanoparticles combined were diminished.
About the Authors
I. A. Minigalieva
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
Russian Federation
Russian Federation
L. I. Privalova
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
Russian Federation
Russian Federation
M. P. Sutunkova
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
Russian Federation
Russian Federation
V. Ya. Shur
The Ural Shared Experimental Facility «Modern nanotechnologies», The Ural Federal University
Russian Federation
Russian Federation
I. E. Valamina
The Central Research Laboratory, The Ural State Medical University
Russian Federation
Russian Federation
O. G. Makeyev
The Central Research Laboratory, The Ural State Medical University
Russian Federation
Russian Federation
V. G. Panov
Institute of Industrial Ecology, the Urals Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
E. V. Grigor'eva
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
Russian Federation
Russian Federation
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Review
For citations:
Minigalieva I.A., Privalova L.I., Sutunkova M.P., Shur V.Ya., Valamina I.E., Makeyev O.G., Panov V.G., Grigor'eva E.V. Combined subchronic toxicity of nickel and manganese oxides nanoparticles, and its decrease due to bioprotectors complex. Russian Journal of Occupational Health and Industrial Ecology. 2016;(10):25-29. (In Russ.)
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