Experience of using subcutaneous interstitial fluid for biomonitoring a dose load in workers of metallurgic industry

Comparative envaluation of metals content of serum and subcutaneous interstitial fluid revealed that levels of chromium, manganese, arsenic, cadmium in these biologic media have no reliable differences (p = 0.056-0.907) but strong correlation (r = 0.52-0.93). Findings are that some metals (nickel, copper, zinc, lead) contents of subcutaneous interstitial fluid have reliable differences in contents of serum and subcutaneous interstitial fluid, but these metals have strong correlations between their contents in the biologic media (r = 0.43-0.72). Chances are that subcutaneous interstitial fluid is a promising medium for biomonitoring of dose load in metallurgic industry workers and enables to increase efficiency of measures reducing risk of occupational hazards influence on the workers' health.

подкожная интерстициальная жидкость, микроиглы, масс-спектрометрия, никель, свинец, медь, цинк, мышьяк, subcutaneous interstitial fluid, micro-needles, mass spectrometry, nickel, lead, copper, zinc, arsenic

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