Expression of caspase-3 and bcl-2 proteins as an indicator of functional state of brain tissue in white rats exposed to argentumarabinogalactane
Abstract
The article presents results on experimental modelling an influence of silver nanoparticles incorporated into natural polymer arabinogalactane matrix on brain tissue of white outbred rats. The rats underwent parenteral injection of silver nanoparticles incorporated into polymer arabinogalactane matrix (dosage of 100 and 500 micrograms of silver per kg of the animal weight). The studies covered expression of 2 proteins participating in apoptosis process, in mitochondrial activation type - сaspase-3 and protein bcl-2. During experiment, the groups examined demonstrated significant dose-dependent effect of bcl- 2 protein expression and increased number of caspase-3 expressed and non-expressed hyperchromic cells under exposure to argentumarabinogalactane - that indicates disorders of cellular structure and apoptosis development.
About the Authors
E. A. Titov
Federal State Budgetary Scientific Institution «East-Siberian Institution of Mediko-Ecological Researches»
Russian Federation
Russian Federation
M. A. Novikov
Federal State Budgetary Scientific Institution «East-Siberian Institution of Mediko-Ecological Researches»
Russian Federation
Russian Federation
L. M. Sosedova
Federal State Institution of Science«Irkutsk Scientific Center»
Russian Federation
Russian Federation
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Review
For citations:
Titov E.A., Novikov M.A., Sosedova L.M. Expression of caspase-3 and bcl-2 proteins as an indicator of functional state of brain tissue in white rats exposed to argentumarabinogalactane. Russian Journal of Occupational Health and Industrial Ecology. 2016;(5):40-43. (In Russ.)
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