Specificity of morphologic changes in target organs, associated with exposure to coal rock dust and fluorine compounds
Abstract
The studies revealed specificity of morphologic changes in target organs, depending on acting occupational hazard. Evidences are that inhalation of coal rock dust causes irreversible sclerotic and degenerative changes mostly in lungs and bronchi even on 6th week of the experiment. In liver, changes in parenchyma and stroma are controlled by reparative processes by 9th week. Accumulation of sodium fluoride in the body causes irreversible necrotic changes mostly in liver, on 6th week of the intoxication. With that, morphologic changes in lungs and bronchi are minor, characterized by immune inflammation with degenerative changes only after the 9th week. Irrespective of the acting hazard, vascular changes are characterized by media and intima hypertrophy with endothelial dystrophy and hyalinosis since the 6th week of the experiment.
About the Authors
N. N. Mikhailova
FSBSI «Research Institute for Complex Problems of Hygiene and Occupational Diseases»
Russian Federation
Russian Federation
V. V. Zakharenkov
FSBSI «Research Institute for Complex Problems of Hygiene and Occupational Diseases»
Russian Federation
Russian Federation
M. S. Bugaeva
FSBSI «Research Institute for Complex Problems of Hygiene and Occupational Diseases»
Russian Federation
Russian Federation
O. I. Bondarev
FSBSI «Research Institute for Complex Problems of Hygiene and Occupational Diseases»
Russian Federation
Russian Federation
A. S. Kazitskaya
FSBSI «Research Institute for Complex Problems of Hygiene and Occupational Diseases»
Russian Federation
Russian Federation
N. V. Kizichenko
FSBSI «Research Institute for Complex Problems of Hygiene and Occupational Diseases»
Russian Federation
Russian Federation
E. V. Ulanova
FSBSI «Research Institute for Complex Problems of Hygiene and Occupational Diseases»
Russian Federation
Russian Federation
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Review
For citations:
Mikhailova N.N., Zakharenkov V.V., Bugaeva M.S., Bondarev O.I., Kazitskaya A.S., Kizichenko N.V., Ulanova E.V. Specificity of morphologic changes in target organs, associated with exposure to coal rock dust and fluorine compounds. Russian Journal of Occupational Health and Industrial Ecology. 2016;(5):11-15. (In Russ.)
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