Assessment of the state of human cognitive functions when performing mental activity in an artificial hypoxic environment
https://doi.org/10.31089/1026-9428-2026-66-2-133-140
EDN: hqpnod
Abstract
Due to the emergence and development of fire safety systems based on a hypoxic environment, it is becoming relevant to assess the mental performance of specialists in conditions of oxygen deficiency.
The study aims to assess the state of the volunteers cognitive functions during the operation of fire protection facilities based on a normobaric nitrogen hypoxic environment.
The authors have assessed the state of the functional state of the body on a laboratory model of mental labor activity using biomedical methods: registration of heart rate, blood pressure and saturation. To assess the dynamics of cognitive activity indicators, they used the Stroop test and visual-motor tests. For a subjective assessment of the condition, the specialists conducted a survey.
The researchers noted a decrease in blood oxygen saturation and an increase in heart rate when in a hypoxic environment. Changes in cognitive function indicators were not associated with the effects of hypoxia, however, scientists noted a minor change in well-being both in the experimental group (increased headache) and in the entire sample (headache, sleepiness, rapid heartbeat).
The results of the study show that when simulating mental activity in a hypoxic environment for 30 minutes, the cognitive functions and well-being of employees do not deteriorate.
Limitations. Limitations are associated with the sample size, but the results obtained from individual volunteers did not contradict each other. The experts conducted a safety study of the fire protection system in artificially created conditions that did not fully correspond to the actual working conditions, but the characteristics of the hypoxic environment were reproduced. The studies were conducted only with an average oxygen content of 14% in the air, since it was assumed that this level was the minimum when using this fire extinguishing system.
Ethics. The study was approved by the Local Ethics Committee of the Izmerov Research Institute of Occupational Health (Minutes No. 2 of the meeting of the Local Ethics Committee dated 02/19/2025).
Contributions:
Shuporin E.S. — research concept and design, text writing, editing;
Chudova E.S. — research concept and design, text writing, editing;
Ilyenko O.V. — writing the text;
Glukhov D.V. — writing the text;
Eremeeva A.G. — data collection and processing;
Kalinina S.A. — data collection and processing;
Vaga I.N. — data collection and processing, editing.
Funding. The study had no funding.
Conflict of interests. The authors declare no conflict of interest.
Received: 15.12.2025 / Accepted: 21.01.2026 / Published: 27.03.2026
About the Authors
Evgenii S. ShuporinRussian Federation
Acting Head of the Laboratory and Researcher at the Laboratory for Personal Protective Equipment and Industrial Exosceletons (Izmerov Research Institute of Occupational Health).
e-mail: ppe-lab@irioh.ru
Elena S. Chudova
Russian Federation
Junior Research Assistant at the Laboratory for Personal Protective Equipment and Industrial Exosceletons (Izmerov Research Institute of Occupational Health).
Oleg V. Ilyenko
Russian Federation
Junior research assistant at the Laboratory for Personal Protective Equipment and Industrial Exosceletons (Izmerov Research Institute of Occupational Health).
Dmitry V. Glukhov
Russian Federation
Head of the Laboratory of Physiology of Labor and Preventive Ergonomics (Izmerov Research Institute of Occupational Health), Dr. of Sci. (Med.).
e-mail: d.gluhov@irioh.ru
Anastasiya G. Eremeeva
Russian Federation
Senior Researcher of Labor Physiology and Preventive Ergonomics of FSBSI IRIOH; assistant of department of occupational medicine, aviation, space and diving medicine of Sechenov First Moscow State Medical University, Cand. of Sci. (Biol.).
e-mail: anastasia.merkoulova@gmail.com
Svetlana A. Kalinina
Russian Federation
Senior Researcher of the Laboratory of Labor Physiology and Preventive Ergonomics (Izmerov Research Institute of Occupational Health), Cand. of Sci. (Biol.).
e-mail: kalininas.a.82@mail.ru
Ivan N. Vaga
Russian Federation
Engineer at the Laboratory for Personal Protective Equipment and Industrial Exosceletons (Izmerov Research Institute of Occupational Health).
References
1. Kimmerle G. Aspects and methodology for the evaluation of toxicological parameters during fire exposure. The Journal of Fire and Flammability Combustion Toxicology Supplement. 1974; 1: 4-51.
2. Angerer P., Nowak D. Working in permanent hypoxia for fire protection-impact on health. Int. Arch. Occ. and Environ. Health. 2003; 76(2): 87–102. https://doi.org/10.1007/s00420-002-0394-5
3. Litvitskiy P.F. Hypoxia. Voprosy sovremennoy pediatrii. 2016; 15(1): 45–58. https://elibrary.ru/vlmfmx (in Russian).
4. DiPasquale D.M., Kolkhorst F.W., Nichols J.F. Effect of acute normobaric hypoxia on peripheral sweat rate. High Altitude Medicine & Biology. 2002; 3(3): 289–292. https://pubmed.ncbi.nlmфnih.gov/12396883/
5. Ivanov A.O., Petrov V.A., Bocharnikov M.S., Bezkishkiy E.N. The possibility of prolonged human exposure to argon-containing gas environments that reduce the fire hazard of hermetic facilities. Ekologiya cheloveka. 2017; 1: 3–8. https://doi.org/10.33396/1728-0869-2017-1-3-8 (in Russian).
6. Ivanov A.O., Motasov G.P. Eroshenko A.Yu., Anistratenko L.G., Groshilin S.M., Linchenko S.N. et.al. The influence of various air environments used to reduce the fire hazard of inhabited hermetic facilities on the functional state of a person. Meditsina katastrof. 2019; 4: 24–28. https://elibrary.ru/hjzfnf (in Russian)
7. Ivanov A.O., Petrov V.A., Bezkishkiy E.N., Gudkov A.B., Eroshenko A.Yu., Groshilin S.M. et.al. Assessment of the long-term consequences of prolonged continuous human exposure to argon-containing hypoxic gas environment. Ekologiya cheloveka. 2017; 6: 9–13. https://doi.org/10.33396/1728-0869-2017-6-9-13 (in Russian).
8. Bezkishkiy E.N., Ivanov A.O., Petrov V.A., Eroshenko A.Yu., Groshilin V.S., Anistratenko L.G. et.al. Human performance during periodic stay in hypoxic air environments that reduce the fire hazard of hermetic facilities. Ekologiya cheloveka. 2018; 9: 4–11. https://doi.org/10.33396/1728-0869-2018-9-4-11 (in Russian).
9. Petrukovich V.M., Ivanov A.O., Zotov M.V. Fedorov S.I. The effect of hypoxia on the mental performance of operators with different strategies for processing information in short-term memory. Vestnik Sankt-Peterburgskogo universiteta. Sotsiologiya. 2015; 3: 27-37. https://elibrary.ru/slsefz (in Russian).
10. McCarthy D., Miller O.T. Effects of mild hypoxia on decision making: a signal detection approach. Engineering Psychology and Cognitive Ergonomics. 1997; 1: 237–244.
11. Loprinzi P.D., Matalgah A., Crawford L. Yu J.J., Kong Z., Wang B. et al. Effects of Acute Normobaric Hypoxia on Memory Interference. Brain Sci. 2019; 9: 323. https://doi.org/10.3390/brainsci9110323
12. Li L., Zhou Y., Zou S., Wang Y. The Effects of High-Altitude Mountaineering on Cognitive Function in Mountaineers: A Meta-Analysis. Int. J. Environ. Res. Public Health. 2023; 20: 5101. https://doi.org/10.3390/ijerph20065101
13. Post T.E., Heijn L.G., Jordan J., van Gerven J.M.A. Sensitivity of cognitive function tests to acute hypoxia in healthy subjects: a systematic literature review. Front. Physiol. 2023; 14: 1244279. https://doi.org/10.3389/fphys.2023.1244279
14. Pilmanis A.A., Balldin U.I., Fischer J.R. Cognition Effects of Low-Grade Hypoxia. Aerosp Med Hum Perform. 2016; 87(7): 596–603. https://doi.org/10.3357/AMHP.4558.2016
15. Ando S., Hatamoto Y., Sudo M., Kiyonaga A., Tanaka H., Higaki Y. The Effects of Exercise Under Hypoxia on Cognitive Function. PLoS ONE. 2013; 8(5): e63630. https://doi.org/10.1371/journal.pone.0063630
16. Blaginin A.A., Zhil'tsova I.I., Mikheeva G.F. Hypoxic training as a method of correction of borderline functional states of the body of operators of complex ergatic systems. In: Hypoxic training as a method of correction of borderline functional states of the body of operators of complex ergatic systems: The monograph. Nizhnevartovsk: Izd-vo Nizhnevart. gos. un-ta, 2015: 106. https://elibrary.ru/xwarnt (in Russian)
17. Zagaynaya E.E., Shchekochikhin D.Yu., Kopylov F.Yu., Glazachev O.S., Syrkin A.L., Sazontova T.G. Interval hypoxic training in cardiology practice. Kardiologiya i serdechno-sosudistaya khirurgiya. 2014; 7(6): 28–34. https://elibrary.ru/tjwtvj (in Russian).
18. Iordanskaya F.A. Hypoxia in athletes' training and factors that increase its effectiveness. Izd-vo «SPORT». 2019: 200. https://elibrary.ru/vrtcpz (in Russian).
19. Rybnikova E.A., Nalivaeva N.N., Zenko M.Y., Baranova K.A. Intermittent hypoxic training as an effective tool for increasing the adaptive potential, endurance and working capacity of the brain. Front. Neurosci. 2022; 16: Art. No. 941740. https://doi.org/10.3389/fnins.2022.941740
20. Chroboczek M., Kostrzewa M., Micielska, K., Grzywacz, T., Laskowski R. Effect of Acute Normobaric Hypoxia Exposure on Executive Functions among Young Physically Active Males. J. Clin. Med. 2021; 10: 1560. https://doi.org/10.3390/jcm10081560
21. Hanning C.D., Alexander-Williams J.M. Pulse oximetry: a practical review. BMJ. 1995; 311(7001): 367−370. https://pubmed.ncbi.nlm.nih.gov/7640545/
22. Grishin O.V., Basalaeva S.V., Ustyuzhaninova N.V. Umantseva N.D., Gladyr' S.N. Reactions of external respiration and intensity of energy metabolism in people who are not adapted to hypoxia in conditions of increasing hypoxia. Byulleten' fiziologii i patologii dykhaniya. 2014; 51: 8–14 (in Russian).
Review
For citations:
Shuporin E.S., Chudova E.S., Ilyenko O.V., Glukhov D.V., Eremeeva A.G., Kalinina S.A., Vaga I.N. Assessment of the state of human cognitive functions when performing mental activity in an artificial hypoxic environment. Russian Journal of Occupational Health and Industrial Ecology. 2026;66(2):133-140. (In Russ.) https://doi.org/10.31089/1026-9428-2026-66-2-133-140. EDN: hqpnod
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