Development of lipids and carbohydrates metabolism disorders caused by drinkable water with high content of chlorine organic compounds
Abstract
Evaluation of effects caused by environmental peroral exposure to chlorine organic compounds revealed that individuals with AG variation of HTR2A gene are a community with increased sensitivity to chloroform and a risk group for lipid and carbohydrates metabolism disorders. Individual risk of endocrine disorders (ICD: E67.8 excessive nutrition and E66.0 obesity) in these individuals is higher than in general population exposed to chloroform at residence (HQ1.72). Serum serotonin level, that is functionally connected with HTR2A gene, is 1.3 times lower vs. the reference group value.
About the Authors
K. P. Luzhetsky
Federal Budget Institution of Science «Federal Research Center of medical and preventive public health risk management technologies»; Federal State Budgetary Educational Institution of Higher Professional Education «Perm State National Research University»
Russian Federation
Russian Federation
O. Yu. Ustinova
Federal Budget Institution of Science «Federal Research Center of medical and preventive public health risk management technologies»; Federal State Budgetary Educational Institution of Higher Professional Education «Perm State National Research University»
Russian Federation
Russian Federation
P. Z. Shur
Federal Budget Institution of Science «Federal Research Center of medical and preventive public health risk management technologies»; Federal State Budgetary Educational Institution of Higher Professional Education «Perm State National Research University»
Russian Federation
Russian Federation
D. A. Kiryanov
Federal Budget Institution of Science «Federal Research Center of medical and preventive public health risk management technologies»; Federal State Budgetary Educational Institution of Higher Professional Education «Perm State National Research University»
Russian Federation
Russian Federation
O. V. Dolgikh
Federal Budget Institution of Science «Federal Research Center of medical and preventive public health risk management technologies»; Federal State Budgetary Educational Institution of Higher Professional Education «Perm State National Research University»
Russian Federation
Russian Federation
V. M. Chigvintsev
Federal Budget Institution of Science «Federal Research Center of medical and preventive public health risk management technologies»
Russian Federation
Russian Federation
A. Ya. Perevalov
State Budget Educational Institution of Higher Professional Education «Perm State Medical University named after academician E.A. Wagner» Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Luzhetsky K.P., Ustinova O.Yu., Shur P.Z., Kiryanov D.A., Dolgikh O.V., Chigvintsev V.M., Perevalov A.Ya. Development of lipids and carbohydrates metabolism disorders caused by drinkable water with high content of chlorine organic compounds. Russian Journal of Occupational Health and Industrial Ecology. 2015;(12):29-32. (In Russ.)
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