Inhalation toxicity of nanodispersed manganese oxide aerosol
Abstract
The article presents results of experimental study concerning acute inhalation toxicity of nanodispersed manganese oxide widely used in novelty goods production. During the technology process, nano-dimensional manganese oxide aerosol could appear in workplace air - that causes danger of the workers' inhalation exposure. Findings are that the studied substance is a nanomaterial with prevalent filiform particles measuring 15-29 nm. The substance is acutely toxic when inhaled as an aerosol. Cl50 for 4-hour exposure for Wistar rats equals 120 mg/m3 (1 jeopardy class). Clinical manifestations of acute intoxication are mostly irritative and neurotoxic effects supported by morphologic studies. Histopathologic changes in brain tissue are cerebellar ischemia with dilated perecellular spaces, faveolate appearance.
About the Authors
V. N. Zvezdin
FBSI «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»
Russian Federation
Russian Federation
M. A. Zemlyanova
FBSI «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»; FSBEI of Higher Professional Education «Perm State National Research University»; FSBEI of Higher Professional Education «Perm National Research Polytechnic University»
Russian Federation
Russian Federation
T. I. Akafieva
FSBEI of Higher Professional Education «Perm State National Research University»
Russian Federation
Russian Federation
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Review
For citations:
Zvezdin V.N., Zemlyanova M.A., Akafieva T.I. Inhalation toxicity of nanodispersed manganese oxide aerosol. Russian Journal of Occupational Health and Industrial Ecology. 2015;(12):13-16. (In Russ.)
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