Immune and genetic markers revealed in women working in technical rubber goods production
Abstract
Medical examination covered female workers engaged into chemical production of technical rubber goods, under combined exposure to chemicals (nitrogen oxides, carbon oxide) and noise exceeding MAC by 3.7-27.5%. Findings are increased phagocytary activity, lower level of serum IgM and IgG, suppressed expression of CD25 and CD95 T-cell receptors, and slower apoptosis induced via Fas receptor - all those indicators associated with work conditions. The disorders revealed are actualized on a basis of genetic variability features of the females, that is characterized by prevalence of mutant allels of FAS and TNFR genes with minor homozygous phenotype.
About the Authors
K. G. Starkova
FBSI «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»
Russian Federation
Russian Federation
O. V. Dolgikh
FBSI «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»; FSBEI of Higher Education «Perm National Research Polytechnic University»
Russian Federation
Russian Federation
A. V. Krivtsov
FBSI «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»
Russian Federation
Russian Federation
O. A. Bubnova
FBSI «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»; FSBEI of Higher Professional Education «Perm State National Research University»
Russian Federation
Russian Federation
V. A. Horoshavin
Perm Region Department of Federal Service on Customers' Rights Protection and Human Well-Being Surveillance
Russian Federation
Russian Federation
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Review
For citations:
Starkova K.G., Dolgikh O.V., Krivtsov A.V., Bubnova O.A., Horoshavin V.A. Immune and genetic markers revealed in women working in technical rubber goods production. Russian Journal of Occupational Health and Industrial Ecology. 2015;(12):10-13. (In Russ.)
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