Use of body adaptation to different oxygen levels in the prevention of occupational lung pathology

The population of resource–producing regions is exposed to a complex complex environmental impact — the combined effects of adverse factors of industrial and non-industrial origin. In coal mining and metallurgical areas, pathology of the bronchopulmonary system is especially common, which primarily reacts subtly to hypoxia in conditions of atmospheric air pollution. It is known that hypoxia underlies the pathogenesis of many occupational diseases, and is often a triggering factor in the development of the pathological process and, as a result, disorders of the energy balance in tissues. In this case, the pathways of intracellular signaling are disrupted, including the redox signaling system, whose action is mediated by the activation of free radical processes and changes in the level of protective proteins in cells. The physiological state and stability of these systems determine the adaptive capabilities of an organism in conditions of environmental disadvantage. In this regard, it is important to search for methods of treatment and prevention of occupational diseases based on the modulation of the redox signaling system. Such methods include interval normobaric hypoxic training, which is based on adaptation, in fact, to hypoxia, as well as to periods of reoxygenation at the time of returning to breathing air with a normal oxygen content. In this review, the authors have systematized studies on the use of adaptation of the human body to different oxygen levels in the prevention of occupational diseases of the bronchopulmonary system.

For this purpose, a search was conducted for literary sources on the following databases: PubMed, Google Scholar, eLibrary, ResearchGate, Web of Science, Scopus and CyberLeninka. The authors used specific keywords and phrases: occupational diseases, pathology of the bronchopulmonary system, prevention of interval normobaric hypoxic and hyperoxic training, redox signaling system, antihypoxic and antioxidant protective proteins. The experimental and clinical data presented in the review on the body's adaptation to different oxygen levels indicate that interval hypoxic and hyperoxic training can be an effective method of preventing occupational lung pathology with significant therapeutic potential for clinical practice in occupational health.

Contributions:
Zhukova A.G. — the concept and design of the review, collection, analysis and interpretation of data (literary sources), writing the text;
Kizichenko N.V. — collection, analysis and interpretation of data (literary sources);
Bugaeva M.S. — collection, analysis and interpretation of data (literary sources);
Mikhailova N.N. — the concept and design of the review, collection, analysis and interpretation of data (literary sources), writing the text;
Filimonov E.S. — collection, analysis and interpretation of data (literary sources);
Sazontova T.G. — the concept and design of the review, collection, analysis and interpretation of data (literary sources), writing the text.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 09.07.2025 / Accepted: 22.09.2025 / Published: 30.10.2025

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