On some ways to optimize and improve standardization of chemical substances in the working zone air

The implementation of the classical approach to justifying standards for safe content of substances in the air of the working zonehas some disadvantages: duration, labor intensity, and use of a large number of animals. Accelerated standardization methods are applicable in case of vast range of unregulated substances.

At the current stage of development of industrial toxicology, when standardizing using accelerated methods, it has become possible to use progressive digital technologies (for example, the QSAR Toolbox software product), as well as the capabilities of mathematical modeling and risk analysis methodology. However, the relevance of the obtained data on the toxic properties and danger of a chemical substance, their adequate implementation for the purposes of hygienic standardization depends on the level of professional competence and training of the toxicologist expert.

To identify critical toxic effects on animals for substances that do not accumulate and have long-term consequences, a 28‑day experiment is optimal in duration.

Ethics. This study did not require the conclusion of the ethics committee.

Contributions:
Vasilkevich V.M. — general concept of the study, writing an abstract, conclusions and editing the text of other sections of the article, formulating generalized conclusions on the text and conclusions;
Evtereva A.A. — research design, search for material and its selection, text writing, design and editing.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 02.07.2025 / Accepted: 09.07.2025 / Published: 05.10.2025

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