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Comparative toxicological characteristics of lavender and coriander oils for predicting their safety in the working area air

https://doi.org/10.31089/1026-9428-2025-65-5-341-350

EDN: lnajzn

Abstract

Introduction. Essential oils have a multifaceted health and therapeutic effect, including antiseptic, anti-infective, anti-inflammatory and even antibiotic effects. Lavender and coriander essential oils also have antihistamine, immunostimulating effects, affect neurological activity — they act as analgesics, sedatives, antispasmodics, etc. Along with the positive pharmacological effects, there is literature evidence of their negative effects on humans with prolonged exposure in relatively high concentrations. Thus, the lack of hygiene standards in the air of the work area poses a threat to the health of workers who come into contact with these oils in production conditions.

The study aims to substantiate hygienic standards in the air of the working area for lavender and coriander oils based on their comparative toxicological characteristics.

Materials and methods. The authors used laboratory animals in their experiments: these are harmless white mice of both sexes, white male rats, Chinchilla rabbits, and white guinea pigs. The average lethal doses (DL50) were determined when the substances were injected into the stomach and abdominal cavity. The scientists evaluated the local irritant effect on the mucous membranes of the eyes with a single application to the conjunctival sac of the rabbit's eye, the effect on the skin with a single and repeated application of oils to the depilated skin of the rabbit's back for 4 hours. Cumulative properties were studied in male mice with daily intragastric administration of the substance for 24 days at a dose of 1000 mg/kg. The experts studied the sensitizing effect of oils on guinea pigs in a combined way. The study of the inhalation hazard of oil vapors in conditions of the maximum possible saturation concentration was carried out under static conditions on white mice in desiccators with a volume of 18 liters at an exposure of 2 hours. The researchers evaluated subchronic toxicity with repeated intragastric administration of essential oils to rats at a dose of 1/10 DL50 for 30 days.

Results. When injected into the abdominal cavity of male mice, according to the OECD and K.K. Sidorov classification, lavender oil belongs to the 5th class of toxicity, and coriander oil belongs to the 5th or 6th class of toxicity. Both oils cause mild irritation of the mucous membranes. With a single application to the skin, lavender oil has a moderate irritant effect, coriander oil has a mild irritant effect. When inhaling the saturating vapors of lavender essential oil, mice showed a tendency to decrease their respiratory rate. The skin-resorptive effect of the studied substances has not been revealed. The study of cumulative properties showed a weak cumulative activity of both oils. No sensitizing effect was detected. When studying subchronic toxicity, it was found that both oils had no significant effect on body weight dynamics, daily intake of feed and water, rectal temperature, respiratory rate, ECG parameters and peripheral blood parameters. The authors found changes in the parameters of the nervous system, an increase in the activity of alkaline phosphatase (ALP), a decrease in the pH of urine, an increase in the level of urea in urine, the excretion of protein and urea in urine, and an increase in urea clearance.

Limitations. In hygienic rationing, the method of justification by analogy is applied.

Conclusion. Taking into account the similarity in the nature of the action of lavender and coriander essential oils and the main component — linalool, as well as by analogy with other similar terpene derivatives, the maximum permissible concentrations of lavender essential oil and coriander essential oil in the air of the working area at the level of 5 mg/m3; vapors; hazard class 3 have been established and approved.

Ethics. The experimental study was conducted in compliance with the necessary regulations (Helsinki Declaration of 2013, GOST 33044-2014 "Principles of good laboratory practice"; Order of the Ministry of Health of the Russian Federation No. 188n dated 04/01/2016 "Rules of good laboratory practice"). The research protocol was approved by the University Commission for the Control of the maintenance and Use of Laboratory Animals of the Pirogov Russian National Research Medical University of the Ministry of Health, Russian Federation, with permission No. 9 dated September 20, 2023, to work with laboratory animals.

Contributions:
Tonshin A.A. — preparation of literature data, writing of text, editing;
Golubeva M.I. — collection and processing of material, data analysis, writing, editing;
Sheina N.I. — research concept and design, text writing, editing;
Bidevkina M.V. — collection and processing of material, statistical data processing, writing text;
Bobrineva I.A. — conducting research, statistical data processing, description of research results;
Fedorova E.A. — conducting research, statistical data processing, description of research results;
Bobrinev E.V. — preparation of literature data and a list of literary sources, statistical data processing.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 02.04.2025 / Accepted: 26.05.2025 / Published: 05.07.2025

About the Authors

Anton A. Tonshin
Izmerov Research Institute of Occupational Health
Russian Federation

Head of the Toxicology Laboratory, Izmerov Research Institute of Occupational Health, Cand. of Sci. (Biol.).

e-mail: atonshin@yandex.ru



Margarita I. Golubeva
Joint-Stock Company "All-Union Scientific Center for the Safety of Biologically Active Compounds"
Russian Federation

Head of the Laboratory of Preventive Toxicology and Hygiene, Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds, Cand. of Sci. (Biol.).

e-mail: golubevamargo@mail.ru



Natalia I. Sheina
Pirogov Russian National Research Medical University
Russian Federation

Professor of the Department of Hygiene, Pirogov Russian National Research Medical University, Dr. of Sci. (Biol.), Professor.

e-mail: ni_sheina@mail.ru



Marina V. Bidevkina
Federal Scientific Center of Hygiene named after F.F. Erisman
Russian Federation

Head of the Toxicology Department, Disinfectology Institute, Federal Scientific Center of Hygiene named after F.F. Erisman of the Rospotrebnadzor, Dr. of Sci. (Med.).

e-mail: mbidevkinaMV@mail.ru



Irina A. Bobrineva
Joint-Stock Company "All-Union Scientific Center for the Safety of Biologically Active Compounds"
Russian Federation

Leading Researcher at the Laboratory of Preventive Toxicology and Hygiene, Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds.

e-mail: ural955@mail.ru



Emma A. Fedorova
Joint-Stock Company "All-Union Scientific Center for the Safety of Biologically Active Compounds"
Russian Federation

Senior Researcher, Laboratory of Preventive Toxicology and Hygiene, Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds.

e-mail: emfed@mail.ru



Evgeny V. Bobrinev
Joint-Stock Company "All-Union Scientific Center for the Safety of Biologically Active Compounds"
Russian Federation

Leading Researcher, Laboratory of Preventive Toxicology and Hygiene, Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds.

e-mail: bobrinev2002@mail.ru



References

1. Perminova A.R. Beneficial properties of vegetable oils for human health. Student scientific and practical conference "Achievements of youth science in the agro-industrial complex. Tyumen; 2022: 139–150. https://elibrary.ru/dltnph (in Russian).

2. Vojtkevich S.A. Essential oils for perfumery and aromatherapy. M.: «Pishhevaja promyshlennost'», 1999. https://clck.ru/3MDHjd (in Russian).

3. Galicheva M.S., Daguzhieva Z.Sh. Biological characteristics and economic importance of narrow-leaved lavender. Proceedings of the All-Russian scientific and practical conference "Agrarian science and education at the present stage of development: experience, problems and ways of their solution". Maykop, 2023: 120–123. https://elibrary.ru/qkjnkg (in Russian).

4. Avilova L.A., Avilov A.N., Kosach L.N. Prospects for the use of essential oils in medical practice. Vestnik nauchnyh konferencij. 2022; 11–3(87): 14–16. https://elibrary.ru/cxyzrg (in Russian).

5. Serebrjakova E.N. Essential oils in the treatment and prevention of acute respiratory diseases in children and adults: effectiveness, safety, availability. Trudnyj pacient. 2015; 13(8–9): 49–56. https://elibrary.ru/xepvul (in Russian).

6. Bilan A.M., Shnjakina T.N., Shherbakov N.P. Local treatment of infected wounds in rabbits in an experiment. Proceedings of the International Scientific and Practical Conference of the Institute of Veterinary Medicine "Problems of Veterinary Medicine, Veterinary and Sanitary Expertise, Biotechnology and Animal Science at the Current Stage of Development of the Agro-Industrial Complex of Russia". 2018: 34–38. https://elibrary.ru/ortswj (in Russian).

7. Mirgorodskij N.A., Kushh G.A., Ivanov S.V. Animal studies of preparations from medicinal lavender raw materials. Aktual'nye nauchnye issledovanija v sovremennom mire. 2021; 79(11–2): 10–13. https://elibrari.ru/lkhzyun (in Russian).

8. Ovcharova A.N., Ostrenko K.S., Nevkrytaja N.V., Kol'cov K.S. The effect of emulsions of essential oils of coriander and fennel on morphological and biochemical parameters of calf blood. Tavricheskij vestnik agrarnoj nauki. 2024; 40(4): 169–182. https://doi.org/10.5281/zenodo.14184710 (in Russian).

9. Pandur E., Balatinácz A. et al. Anti-inflammatory effect of lavender (Lavandula angustifolia Mill.) essential oil prepared during different plant phenophases on THP-1 macrophages. BMC Complement Med. Ther. 2021; 21(1): 287–303. https://doi.org/10.1186/s12906-021-03461-5

10. Omar A., Barakat M., Alzaghari L.F. et al The effect of Jordanian essential oil from coriander seeds on antioxidant, anti-inflammatory, and immunostimulatory activities using RAW 246.7 murine macrophages. PLoS One. 2024; 19(8): 0297250–0297266. https://doi.org/10.1371/journal.pone.0297250

11. Poliksenova V.D. Plant extracts and essential oils as potential biofungicides. Uspehi medicinskoj mikologii. 2024; 26: 47–5. https://elibrary.ru/otcpxw (in Russian).

12. Schilder H. Effects and side-effects of essential oils. Essential Oils and Aromatic Plants. 1985: 217–231. https://link.springer.com/chapter/10.1007/978-94-009-5137-2_26 (Accessed 04.05.2023).

13. Rudoj D.V., Ol'shevskaja A.V., Pavlov P.D., Odabashjan M.Ju. et al. Lavender and its interaction with the nervous system. Collection of scientific papers of the III international forum "Youth in the AIC". Rostov-on-Don, 2022: 41–44. https://doi.org/10.23947/young.2022.41-44 https://elibrary.ru/arbcoa (in Russian).

14. de Melo Alves Silva L.C., de Oliveira Mendes F.C., de Castro Teixeira F. et al. Use of Lavandula angustifolia essential oil as a complementary therapy in adult health care: A scoping review. Heliyon. 2023. 9(5): 15446–15454. https://doi.org/10.1016/j.heliyon.2023.e15446

15. Sharipov H.S., Azonov D.A. Comparative study of hepatoprotective properties of coriander, lavender essential oils and olimethin in toxic liver damage ССl4. Zdravoohranenie Tadzhikistana. 2009; 1(300): 62–67. https://elibrary.ru/nydvlh (in Russian).

16. Talebi S.M., Naser A., Ghorbanpour M. Chemical composition and antimicrobial activity of the essential oils in different populations of Coriandrum sativum L. (coriander) from Iran and Iraq. Food Sci. Nutr. 2024; 12(6): 3872–3882. https://doi.org/10.1002/fsn3.4047

17. Suvorova T.Ju. Fragrances and oils. Rostov-on-Don: Feniks, 2005 (in Russian).

18. Salem M.A., Manaa E.G., Osama N. et al. Coriander (Coriandrum sativum L.) essential oil and oil-loaded nano-formulations as an anti-aging potentiality via TGFβ/SMAD pathway. Sci. Rep. 2022; 12(1): 6578–6592. https://doi.org/10.1038/s41598-022-10494-4

19. Al-Khayri J.M., Banadka A., Nandhini M. et al. Essential Oil from Coriandrum sativum: A review on Its Phytochemistry and Biological Activity. Molecules. 2023; 28(2): 696–718. https://doi.org/10.3390/molecules28020696

20. Schilcher H. Effects and side-effects of essential oils. Essential Oils and Aromatic Plants. 1985: 217–231. https://clck.ru/3MDHTn (Accessed: 04.05.2023).

21. Sharipov H.S., Azonov D.A. Pharmacotoxicological studies of coriander essential oil in toxic hepatitis. Izvestija akademii nauk respubliki Tadzhikistan. 2009; 1: 66–71. https://elibrary.ru/oyocsr (in Russian).

22. Lazarev N.V. Harmful Substances in Industry. Part 1. Organic Substances. M.,L., «Goshimizdat», 1963: 698-699 (in Russian).

23. Mekonnen A., Tesfaye S., Christos S.G., Dires K., Zenebe T., Zegeye N., Shiferaw Y., Lulekal E. Evaluation of Skin Irritation and Acute and Subacute Oral Toxicity of Lavandula angustifolia Essential Oils in Rabbit and Mice. J Toxicol. 2019; 2019: 5979546. https://doi.org/10.1155/2019/5979546

24. Safety Data Sheet Organic Coriander Seed Essential Oil. www.nhrorganicoils.com Reference date 04.05.2023

25. Lavender essential oil. OAO «Nizhfarm. TU 9151‑002‑00480081-2010. Predstavleno AO «Nizhfarm», 2023 (in Russian).

26. Coriander essential oil. JSC Nizhpharm. TU 9151‑006‑00480081-2010 with amendments No. 1 and No. 2. Submitted by JSC Nizhpharm, 2023 (in Russian).

27. Prozorovskij V.B. Using the Ordinary Least Squares Method for Probit Analysis of the Mortality Curve. Farmakologija i toksikologija. 1962; 22(1): 115–120. https://elibrary.ru/zvengf (in Russian).

28. Alekseeva O.G., Petkevich A.I. On the methodology for determining the allergenic properties of chemical substances. Gigiena i sanitarija. 1972; 3: 64–67. https://elibrary.ru/zvengf (in Russian).

29. Materials for substantiation of the maximum permissible concentration (MPC) of synthetic linalool in the air of the working zone. All-Russian Research Institute of Synthetic and Natural Fragrance Substances (VNIISNDV), Moscow, Research Institute of Occupational Hygiene and Occupational Diseases of the USSR Academy of Medical Sciences, Moscow, 1988. Archive of the Industrial Toxicology Section (in Russian).

30. Materials on substantiation of the maximum permissible concentration (MPC) of linalyl acetate in the air of the working zone. I.M. Sechenov Moscow Medical Academy. Moscow, 1992. Archive of the Industrial Toxicology Section (in Russian).

31. Burdock G.A., Carabin I.G. Safety assessment of coriander (Coriandrum sativum L.) essential oil as a food ingredient. Food Chem. Toxicol. 2009; 47(1): 22–34. https://doi.org/10.1016/j.fct.2008.11.006

32. European Food Safety Authority (EFSA). Scientific Opinion on the safety of "coriander seed oil as a Novel Food ingredient. EFSA Journal. 2013; 11(10): 3422. https://clck.ru/3MDHPT (Accessed: 29.05.2023).


Review

For citations:


Tonshin A.A., Golubeva M.I., Sheina N.I., Bidevkina M.V., Bobrineva I.A., Fedorova E.A., Bobrinev E.V. Comparative toxicological characteristics of lavender and coriander oils for predicting their safety in the working area air. Russian Journal of Occupational Health and Industrial Ecology. 2025;65(5):341-350. (In Russ.) https://doi.org/10.31089/1026-9428-2025-65-5-341-350. EDN: lnajzn

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