On new screening biomarker to evaluate health state in personnel engaged into chemical weapons extinction
Abstract
The work was aimed to find new screeding parameters (biomarkers) for evaluation of health state of workers engaged into enterprises with hazardous work conditions, as exemplified by «Maradykovskyi» object of chemical weapons extinction. Analysis of 27 serum cytokines was conducted in donors and the object personnel with various work conditions. Findings are statistically significant increase of serum eotaxin in the personnel of «dirty» zone, who are regularly exposed to toxic agents in individual filter protective means over the working day. For screening detection of health disorders in the object personnel, the authors suggested new complex biomarker - ratio Eotaxin* IFNγ/TNFα that demonstrates 67.9% sensitivity and 87.5% specificity in differentiating the «dirty» zone personnel and other staffers.
About the Authors
N. G. Voitenko
Research Institute of Hygiene, Occupational Pathology and Human Ecology
Russian Federation
Russian Federation
V. V. Garniuk
Research Institute of Hygiene, Occupational Pathology and Human Ecology
Russian Federation
Russian Federation
D. S. Prokofieva
Research Institute of Hygiene, Occupational Pathology and Human Ecology
Russian Federation
Russian Federation
N. V. Gontcharov
Research Institute of Hygiene, Occupational Pathology and Human Ecology; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Voitenko N.G., Garniuk V.V., Prokofieva D.S., Gontcharov N.V. On new screening biomarker to evaluate health state in personnel engaged into chemical weapons extinction. Russian Journal of Occupational Health and Industrial Ecology. 2015;(3):38-42. (In Russ.)
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