Development of new methods for predicting hygienic standards for the content of medicines in the air of the working area on the example of non-steroidal anti-inflammatory drugs

Introduction. Experts predict the hygienic standards of medicines in Russia in accordance with the methods common to all medicines (MG 1.1.726-98), developed more than 25 years ago on the basis of experimental materials obtained during the rationing of 66 medicines. By 2023, the content of more than 230 medicines of various pharmacological orientation has already been normalized in the air of the working area. Such an array of experimental materials makes it possible to study the relationship between the values of standard toxicological and pharmacological indicators and hygienic standards approved by law, already within the framework of individual pharmacological groups of drugs with the same mechanism of action, as well as to develop new forecasting approaches taking into account the specifics of pharmacological actions.

The study aims to evaluate existing and develop new computational methods for predicting hygienic standards for the content of medicines in the air of the working area, taking into account the specifics of pharmacological action on the example of a group of nonsteroidal anti-inflammatory drugs.

Materials and methods. Scientists studied the pharmacological group of nonsteroidal anti-inflammatory drugs. The main method of the study was a multiple correlation and regression analysis of the relationship between the values of hygienic standards and the values of toxicological and pharmacological parameters. As a mathematical model, the authors adopted a double logarithmic model. We evaluated the suitability of the mathematical model by Fisher's F-criterion, the statistical significance of the regression coefficients by the Student's t-criterion, the quality of approximation by the standard deviation, and the accuracy of the calculation by the average multiplicity of differences.

Results. Experts have identified in a group of 15 non-steroidal anti-inflammatory substances normalized in the air of the working area, a reliable relationship between the values of toxicometry parameters and the values of therapeutic doses, on the one hand, and the values of hygiene standards, on the other. Scientists have developed and selected the most accurate and statistically significant formulas for calculating the safe concentrations of this group of drugs in the air of the working area. We found that the accuracy of the formulas developed by us, taking into account the specifics of the pharmacological action, is higher than that of the formulas from MG 1.1.726-98. From the formulas developed earlier, equations with greater accuracy for the hygienic rationing of nonsteroidal anti-inflammatory drugs have been identified.

Conclusion. Taking into account the specifics of the pharmacological action of medicines when developing mathematical models for calculating the hygienic standard increases the accuracy of the forecast.

Contribution:
Tonshin A.A. — research design, mathematical calculations and writing the text;
Tkacheva T.A. — research concept, editing;
Kayutina S.V. — data collection and processing;
Golubeva M.I. — research concept, editing.

Funding. The study was carried out within the framework of the State Task of research No. FGFE-2022-0006.

Conflict of interests. The authors declare no conflict of interests.

Received: 02.08.2023 / Accepted: 11.08.2023 / Published: 05.10.2023

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