Experimental study of quantitative and corpuscular properties of rat’s leukocytes under the influence of ore
https://doi.org/10.31089/1026-9428-2023-63-8-551-557
EDN: gxexpk
Abstract
The study aims to explore the effect of copper-zinc pyrite ore on the quantitative and corpuscular properties of peripheral blood leukocytes.
Results. In the experimental group of animals after 30 days of ore intoxication, the average volume and number of granulocytes and monocytes increased statistically compared to the control. The authors have revealed a correlation between the parameters of cell distribution and the average volume in leukocyte populations at different times of ore intoxication.
Limitations. The limitation of this study is the model of oral administration of copper-zinc pyrite ore in the form of an aqueous suspension.
Contribution:
Ayupova A.R. — the concept and design of the study, data collection and processing, the text writing;
Ziyakaeva K.R. — data collection and processing, the text writing;
Kayumova A.F. — the concept and design of the study, the editing;
Shamratova V.G. — the editing.
Funding. The study had no funding.
Received: 26.06.2023 / Accepted: 18.08.2023 / Published: 05.09.2023
About the Authors
Albina R. AyupovaRussian Federation
Klara R. Ziyakaeva
Russian Federation
The Associate Professor at the Department of Normal Physiology of the Bashkir State Medical University, Cand. of Sci. (Biol.).
e-mail: klazia@yandex.ru
Aliya F. Kayumova
Russian Federation
Valentina G. Shamratova
Russian Federation
References
1. Renu K., Chakraborty R., Myakala H., Koti R., Famurewa A.C., Madhyastha H., et al. Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) — induced hepatotoxicity. Chemosphere. 2021; 271: 129735. https://doi.org/10.1016/j.chemosphere.2021.129735
2. Liu Y.H., Wang C.W., Wu D.W., Lee W.H., Chen Y.C., Li C.H., et al. Association of Heavy Metals with Overall Mortality in a Taiwanese Population. Nutrients. 2021; 13(6): 2070. https://doi.org/10.3390/nu13062070
3. Fu Z., Xi S. The effects of heavy metals on human metabolism. Toxicol Mech Methods. 2020 Mar; 30(3): 167–176. https://doi.org/10.1080/15376516.2019.1701594
4. Kim J.J., Kim Y.S., Kumar V. Heavy metal toxicity: An update of chelating therapeutic strategies. J Trace Elem Med Biol. 2019; 54: 226–231. https://doi.org/10.1016/j.jtemb.2019.05.003
5. Hryntsova N., Hodorová I., Mikhaylik J., Romanyuk A. A Response of the Pineal Gland in Sexually Mature Rats under Long-term Exposure to Heavy Metal Salts. Prague Med Rep. 2022; 123(4): 225–242. https://doi.org/10.14712/23362936.2022.21
6. Huat T.J., Camats-Perna J., Newcombe E.A. Metal Toxicity Links to Alzheimer’s Disease and Neuroinflammation. J Mol Biol. 2019; 431(9): 1843–1868. https://doi.org/10.1016/j.jmb.2019.01.018
7. Vlasova N.V., Masyagutova L.M., Aralbaev H.F. Changes in hematological indicators in mining industry workers. Meditsina truda i ekologiya cheloveka. 2020; 23(3): 21–28 (in Russian).
8. Bakirov A.B., Suleimanov R.A., Valeyev T.K. experience of assesing water-related health risks to the population of the surrounding areas of mining. Meditsina truda i ekologiya cheloveka. 2016; 2: 5–13 (in Russian).
9. Wang Y., Tang Y., Li Z., Hua Q., Wang L., Song X., et al. Joint Toxicity of a Multi-Heavy Metal Mixture and Chemoprevention in Sprague Dawley Rats. Int. J. Environ. Res. Public Health. 2020; 17(4): 1451.
10. Huang C.H., Hsieh C.Y., Wang C.W., Tu H.P., Chen S.C., Hung C.H., et al. Associations and Interactions between Heavy Metals with White Blood Cell and Eosinophil Count. Int. J. Med. Sci. 2022; 19(2): 331–337. https://doi.org/10.7150/ijms.68945
11. Ayupova A.R., Ziyakaeva K.R., Kayumova A.F., Shamratova V.G., Samokhodova O.V., Fazlyakhmetova M.Ya. The influence of copper-zinc pyrite ore on the volumetric characteristics of leukocytes in the experiment. Modern Probl. of Sci. and Education. 2022; 5: 121. https://doi.org/10.17513/spno.32136 (in Russian).
12. Balabekova M.K. Organotoxic effects of heavy metals. Modern Problems of Science and Education. 2012; 1: 135–138 (in Russian).
13. Pavlov N.A., Nadezhdin S.V. Reactions of rat blood leukocytes to soluble and insoluble forms of metals in in vivo and in vitro experiments. Regional’nye geosistemy. 2010; 21: 88–92 (in Russian).
14. Ziyakaeva K.R., Kayumova A.F. Toxic effect of copper-zinc pyrite ore on erythropoiesis in chronic experiment. Siberian Scientific Medical Journal. 2020; 40(6): 70–79. https://doi.org/10.15372/SSMJ20200607 (in Russian).
15. Ziyakaeva K.R., Kayumova A.F., Shamratova V.G. Disregulatory shifts in the red blood system during prolonged intoxication with copper-zinc-pyrite ore (experimental study). Med. truda i prom. ekol. 2021; 61 (4): 224–230 (in Russian).
16. Pershyn O. Characteristics of rat peripheral blood leukocyte population composition under the action of plumbum cations. Universum: Med. and Pharmac. 2015; 17(4). https://clck.ru/35AUcc (in Russian).
17. Petrosyan E.A., Botashev A.A., Tereshchenko O.A., Pomeshchik Yu.V., Gubaz S.G. Phagocytic activity of neutrophil granulocytes in experimental biliary peritonitis. Experimen. and Clinical Gastroenter. 2011; 6: 42–44 (in Russian).
18. Rafikov S.Sh., Suleimanov R.A., Valeev T.K. The impact of the mining industry on the environmental and public health (literature review). Meditsina truda i ekologiya cheloveka. 2021; 27(3): 62–75 (in Russian).
19. Firsova S.S., Bucharskaya A.B., Maslyakova G.N., Zlobina O.V., Matveeva O.V., Bugaeva I. O. et al. Changes in morphological parameters of bone marrow and peripheral blood during prolonged exposure to gold nanoparticles. Izvestiya Saratovskogo universiteta. 2011; 2: 5–57 (in Russian).
20. Shamratova V.G., Tupinevich G.S. Gender features of the ratio of volume and number of blood cells. Morfologiya. 2019; 155(2): 322 (in Russian).
Review
For citations:
Ayupova A.R., Ziyakaeva K.R., Kayumova A.F., Shamratova V.G. Experimental study of quantitative and corpuscular properties of rat’s leukocytes under the influence of ore. Russian Journal of Occupational Health and Industrial Ecology. 2023;63(8):551-557. (In Russ.) https://doi.org/10.31089/1026-9428-2023-63-8-551-557. EDN: gxexpk