Assessment of the prevalence of potentially occupation-related lung cancers by the "case–control" study

Introduction. Lung cancer is the most common type of occupational malignancies. A "case–control" study may allow an initial assessment of the impact of certain factors on the risk of developing malignant neoplasms.

The study aims to conduct a "case–control" study by collecting data through a questionnaire and identifying a possible link between the incidence of lung malignancies and professional activity.

Materials and methods. Researchers conducted a case-control study in the Rostov region. The authors carried out data collection by the questionnaire method.

Results. Specialists received 363 questionnaires for persons from the "cases" group and 599 for persons from the control group. The ratio of lung cancer detection risks in coal industry workers was higher compared to the population control (OR=1,229(0.891–1.696)), was lower compared to humanitarian workers (OR=0.983(0.645–1.500)). The risk ratio of lung cancer detection in smoking men was higher (OR=1.997; CI (0.792–5.036)). Workers who smoke more than one pack per day have a higher risk of lung cancer detection (OR=1,667(0.860–3.231)). Statistically significant risk ratio in the group of construction sector workers compared to humanitarian workers OR=2.275(1.244–4.159), as well as in the group of technical professions OR=0.606(0.404–0.909).

Limitations. Insufficient research potential due to the high level of refusal of respondents, administrative and legal restrictions, little information and its inaccuracy.

Conclusion. There was a tendency to increase the risk of lung cancer among coal industry workers compared to other professions, as well as a tendency to increase the risk of lung cancer among coal industry workers who smoke more than one pack per day (but without achieving statistically reliable indicators). Further epidemiological studies in this direction are needed based on the use of modern digital databases.

Ethics. Protocol No. 4 of April 17, 2019 of the meeting of the Local Ethics Committee of the Izmerov Research Institute of Occupational Health.

Contribution:
Bukhtiyarov I.V. — development of the concept and design of research, editing, writing the text;
Kovalevsky E.V. — development of the concept and design of research, data collection and processing, editing, editing, writing text;
Pictushanskaya T.E. — data collection and processing, writing text;
Tshomaria I.M. — data collection and processing, text writing;
Khvalyuk P.O. — writing the text.

Funding. The work was carried out by order of the Ministry of Health, Russian Federation. The work was carried out in cooperation with the International Agency for Research on Cancer of the World Health Organization (Department of Epidemiology of the Environment and Lifestyle, Joachim Schutz and Ann Olsson): methodological support and advice on research planning, questionnaire development, approaches to the selection of research subjects and the choice of methods of statistical data analysis.

Conflict of interests. The authors declare no conflict of interests.

Received: 09.02.2023 / Accepted: 29.02.2023 / Published: 20.03.2023

1. Kaprin A.D., Starinsky V.V., Shakhzadova A.O. eds. Malignant neoplasms in Russia in 2020 (incidence and mortality). M.: P.A. Herzen Moscow State Medical Research Institute — Branch of the Federal State Budgetary Institution «NMIC of Radiology» of the Ministry of Health of Russia; 2021.

2. Malhotra J., Malvezzi M., Negri E., La Vecchia C., Boffetta P. Risk factors for lung cancer worldwide. European Respiratory Journal. 2016; 48: 889–902. https://doi.org/10.1183/13993003.00359-2016

3. Olsson A., Schubauer-Berigan M., Schüz J. Strategies of the International Agency for Research on Cancer (IARC/WHO) to reduce the occupational cancer burden. Russian Journal of Occupational Health and Industrial Ecology. 2021; 61(3): 140–54. https://doi.org/10.31089/1026-9428-2021-61-3-140-154 (in Russian).

4. Loomis D., Guha N., Hall A.L. et al. Identifying occupational carcinogens: an update from the IARC Monographs. Occupational and Environmental Medicine. 2018; 75: 593–603.

5. Kontsevaya A.V., Balanova Y.A., Myrzamatova A.O., Khudyakov M.B., Mukaneeva D.K., Drapkina O.M. Economic losses due to oncologic diseases related to modifiable risk factors. Health Risk Analysis. 2020; 1: 133–41. https://doi.org/10.21668/health.risk/2020.1.15.eng (in Russian).

6. Federal project «Fight against oncological diseases». https://minzdrav.gov.ru/poleznye-resursy/natsproektzdravoohranenie/onko#downloadable (accessed 31.01.2023) (in Russian).

7. Tenny S., Kerndt C.C., Hoffman M.R. Case Control Studies. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2022 Jan.

8. Hovanec J., Siemiatycki J., Conway D.I., Olsson A., Stücker I., Guida F. et al. Lung cancer and socioeconomic status in a pooled analysis of case-control studies. PLoS ONE. 2018: 13(2): e0192999. https://doi.org/10.1371/journal.pone.0192999

9. Denholm R., Schüz J., Straif K., et al. Is previous respiratory disease a risk factor for lung cancer? Am J Respir Crit Care Med. 2014; 190: 549–59. https://doi.org/10.1164/rccm.201402-0338O

10. Taeger D. et al. Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case-control studies. Scand J Work Environ Health. 2015; 41(5): 467–77 (Epub). https://doi.org/10.5271/sjweh.3513

11. Li L., Jiang M., Li X., Baosen Zhou B. Association between Coalmine Dust and Mortality Risk of Lung Cancer: A Meta-Analysis. BioMed Research International. 2021; Volume 2021: article ID 6624799. https://doi.org/10.1155/2021/6624799

12. Tikhonova G.I., Piktushanskaya T.E., Gorchakova T.Yu., Churanova A.N., Bryleva M.S. Mortality study in a cohort of coal miners with occupational diseases. Russian Journal of Occupational Health and Industrial Ecology. 2017; 12: 6–11 (in Russian)

13. IARC Monographs Priorities Group. Advisory Group recommendations on priorities for the IARC Monographs. Lancet Oncol. 2019; 20(6): 763–4. https://doi.org/10.1016/S1470-2045(19)30246-3

14. Burkhart G., Schulte P.A., Robinson C. et al. Job tasks, potential exposures, and health risks of laborers employed in the construction industry. Am J Ind Med. 1993; 24: 413–25. https://doi.org/10.1002/ajim.4700240407

15. Shankar A., Dubey A., Saini D., Singh M., Prasad C.P., Roy S., Bharati S.J., Rinki M., Singh N., Seth T., Khanna M., Sethi N., Kumar S., Sirohi B., Mohan A., Guleria R., Rath G.K. Environmental and occupational determinants of lung cancer. Transl Lung Cancer Res. 2019; Suppl. 1: S31–S49. https://doi.org/10.21037/tlcr.2019.03.05

16. Federal Law «On Personal Data» dated 27.07.2006 No. 152-FZ. https://www.consultant.ru/document/cons_doc_LAW_61801/ (accessed 31.01.2023) (in Russian).

17. Kauppinen T., Heikkilä P., Plato N., Woldbæk T., Lenvik K., Johnni Hansen J., Kristjansson V., Pukkala E. Construction of job-exposure matrices for the Nordic Occupational Cancer Study (NOCCA). Acta Oncologica. 2009; 48(5): 791–800. https://doi.org/10.1080/02841860902718747

18. SYNERGY Project (IARC). Available at: https://synergy.iarc.fr/ (accessed 30.01.2023).

19. Rajput Z., Hering K.G., Kraus T., et al. Investigating the association between occupational exposure to asbestos and ovarian carcinoma: results from a pilot study in Germany. BMC Public Health. 2019; 19(1): 1341. https://doi.org/10.1186/s12889-019-7590-7

20. Arfken C.L., Balon R. Declining participation in research studies. Psychother Psychosom. 2011; 80(6): 325–8.

21. Ørstavik R.E., Jacobsen G.W. Is community spirit a thing of the past? Tidsskr Nor Laegeforen. 2016; 136(12–13): 1059. https://doi.org/10.4045/tidsskr.16.0539 (in Eng., Norw.).