The study of the long-term effects of industrial substances by toxicologists of the I.V. Sanotsky School
https://doi.org/10.31089/1026-9428-2022-62-11-711-717
Abstract
One of the areas of scientific research that deeply interested I.V. Sanotsky was the study of the long-term effects of the influence of chemical compounds on the body, which is one of the most urgent problems of modern toxicology.
The study aims to analyze and evaluate the results of experimental studies of chemicals with long-term effects, on the basis of which a methodology for hygienic rationing of these substances in preventive toxicology.
The researchers have conducted a literature search for the period 1975–2020 according to the data of the scientific electronic library elibrary.ru and the archive of the Izmerov Research Institute of Occupational Health by keywords: preventive toxicology, long-term effects, hygienic standardization.
The results of experimental studies of chemicals with long-term effects allowed us to scientifically substantiate the basic principles of establishing MPC during hygienic rationing:
– selection of an experimental model, issues of data transfer from animals to humans;
– dependence of the studied effects on the dose or concentration of chemicals;
– threshold of effects;
– dependence of the effect on the time of exposure and observation;
– selectivity of the effect of poisons on reproductive function;
– sanitary standardization of the content of chemical compounds with a specific effect on reproductive function.
As a result of the long-term work of the Department of Industrial Toxicology, specialists have developed methodological approaches, and also have created tested, modernized, unified guidelines for the system of institutions whose task was to obtain data for the toxicological assessment of new substances with long-term effects to determine harm thresholds.
Contribution:
Fesenko M.A. — research concept and design, data analysis and interpretation.
Funding. The study had no funding.
Conflict of interests. The author declares no conflict of interests.
Received: 17.11.2022 / Accepted: 23.11.2022 / Published: 12.12.2022
About the Author
Marina A. Fesenko
Izmerov Research Institute of Occupational Health
Russian Federation
Russian Federation
The Head of the Laboratory for the Prevention of Reproductive Health Disorders of employees, Izmerov Research Institute of Occupational Health, Dr. of Sci. (Med.).
e-mail: marnast@mail.ru
References
1. Chemical Substances — CAS REGISTORY. https//www.cas.org/content/chemical-substances (Accessed 02.11.2022).
2. Rahmanin Yu.A. Actualization of methodological problems of regulation of chemical pollution and study of its impact on the quality of life and health of the population. Collection: Methodological problems of studying, evaluating and regulating chemical pollution of the environment and its impact on public health. Proceedings of the Plenum of the Scientific Council of the Russian Federation on Human Ecology and Environmental Health, edited by Academician of the Russian Academy of Sciences Yu.A. Rakhmanin; 2015: 3–11.
3. Decree of the President of the Russian Federation of March 11, 2019 No. 97 "On the Fundamentals of the State Policy of the Russian Federation in the field of ensuring chemical and biological safety for the period up to 2025 and beyond."
4. Sanotsky I.V., Fomenko V.N. Long term effects of chemicals on the organism. М.: Meditsina; 1979: 232.
5. Sanotsky I.V. Influence of different doses of radiothorium on reproduction. Dissertation of the candidate of medical sciences. Moscow; 1952.
6. Sanotsky I.V., Ulanova I.P. Criteria of harmfulness in hygiene and toxicology in assessing the danger of chemical compounds. M.: Meditsina; 1975.
7. Moscow School of Industrial Toxicologists: in 2 volumes, edited by Corresponding Member of the Russian Academy of Medical Sciences I.V. Sanotsky. Moscow: Novaya Liniya Publishing House, 2011; T.1.
8. Moscow School of Industrial Toxicologists: in 2 volumes, edited by Corresponding Member of the Russian Academy of Medical Sciences I.V. Sanotsky. Moscow: Novaya Liniya Publishing House, 2011; T.2.
9. Pravdin N.S. Manual of industrial toxicology. T.1 Moscow; Biomedgiz; 1934.
10. Kasatkin A.N. Experimental study of the criterion significance of the state of the female reproductive system for assessing the danger of new industrial substances. Abstract of the thesis of a candidate of medical sciences. Gorkiy; 1989.
11. Fesenko M.A. The use of modern morphometric methods for predicting reproductive disorders. Problems of toxicology and applied ecology. Collection of reports of the international symposium. Leningrad; 1991: 257-8.
12. Sheina N.I. The influence of tobacco smoke on the mother-fetus system and the development of offspring. Akusherstvo i ginekologiya. 1987; 1: 52–6.
13. Sanotsky I.V., Grodetskaya N.S. Chemical pollution of the environment and premature aging. Prikladnaya toksikologiya. 2010; 1(2): 10–14.
14. Sanotsky I.V. Sanotsky I.V. Some results and prospects for the development of general and industrial toxicology at the Institute of Occupational Medicine of the Russian Academy of Medical Sciences. Med. truda i prom. ekol. 2008; 6: 29–33.
Review
For citations:
Fesenko M.A. The study of the long-term effects of industrial substances by toxicologists of the I.V. Sanotsky School. Russian Journal of Occupational Health and Industrial Ecology. 2022;62(11):711-717. (In Russ.) https://doi.org/10.31089/1026-9428-2022-62-11-711-717
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