Immunological features and prognosis in modern forms of occupational lung diseases

Introduction. At present, despite scientific and technical progress and the introduction of modern safe technologies in production related to dust formation and dust emission, an increased risk of developing dust pathology of the lungs is noted in the machine-building and mining industries. Chronic lung diseases, including occupational diseases, are one of the most urgent problems of modern respiratory medicine and cause a decrease in the quality of life, working capacity and increased mortality of the working population. The features of the course of dusty lung diseases at the early stages of the pathological process are insufficiently studied, and functional and biological markers — criteria for individual prognosis of the patient’s condition-have not been identified.

The aim of the study is to assess the immunological profile, growth factors, early diagnosis and prognosis of current forms of occupational lung diseases.

Materials and methods. To assess the cytokine profile of dust lung diseases (varying degrees of severity of chronic dust bronchitis, silicosis and pneumoconiosis from exposure to welding aerosols), 161 people were examined in the main groups: 1 group–35 people who had long-term industrial contact with industrial fibrogenic aerosols, who did not show clinical and radiological signs of lung damage (contact); 2 group–39 people with chronic dust bronchitis; Group 3–56 patients with silicosis (mainly interstitial form, x-ray characteristics of the process corresponded to categories from s1 to u2); group 4–31 patients with pneumoconiosis from exposure to highly dispersed welding aerosols (mainly nodular form, x-ray characteristics of the process corresponded to categories P1, P2, q1, q2). The 5 (control) group included 60 people-donors of the Samara Regional Clinical Blood Transfusion Station, as well as employees of industrial enterprises and institutions who did not have contact with industrial fibrogenic aerosols (healthy).

Serum levels of immunoglobulins A, M, and G were determined by radial Manchini immunodiffusion. Evaluation of total immunoglobulin e (IgE), immunoglobulins A, M, G (Ig A, M, G), cytokines: interleukins 1α, 1β, 4, 8 (IL–1α, IL–1β, IL–4, IL–8), interferon γ (ifny), tumor necrosis factor α (TNFa), fibroblast growth factor (FGF2), vascular endothelial growth factor (VEGF) in blood serum it was carried out by the method of solid-phase Enzyme immunoassay.

in the machine-building and mining industries. Chronic lung diseases, including occupational diseases, are one of the most urgent problems of modern respiratory medicine and cause a decrease in the quality of life, working capacity and increased mortality of the working population. The features of the course of dusty lung diseases at the early stages of the pathological process are insufficiently studied, and functional and biological markers — criteria for individual prognosis of the patient’s condition-have not been identified.

The aim of the study is to assess the immunological profile, growth factors, early diagnosis and prognosis of current forms of occupational lung diseases.

Materials and methods. To assess the cytokine profile of dust lung diseases (varying degrees of severity of chronic dust bronchitis, silicosis and pneumoconiosis from exposure to welding aerosols), 161 people were examined in the main groups: 1 group–35 people who had long-term industrial contact with industrial fibrogenic aerosols, who did not show clinical and radiological signs of lung damage (contact); 2 group–39 people with chronic dust bronchitis; Group 3–56 patients with silicosis (mainly interstitial form, x-ray characteristics of the process corresponded to categories from s1 to u2); group 4–31 patients with pneumoconiosis from exposure to highly dispersed welding aerosols (mainly nodular form, x-ray characteristics of the process corresponded to categories P1, P2, q1, q2). The 5 (control) group included 60 people-donors of the Samara Regional Clinical Blood Transfusion Station, as well as employees of industrial enterprises and institutions who did not have contact with industrial fibrogenic aerosols (healthy).

Serum levels of immunoglobulins A, M, and G were determined by radial Manchini immunodiffusion. Evaluation of total immunoglobulin e (IgE), immunoglobulins A, M, G (Ig A, M, G), cytokines: interleukins 1α, 1β, 4, 8 (IL–1α, IL–1β, IL–4, IL–8), interferon γ (ifny), tumor necrosis factor α (TNFa), fibroblast growth factor (FGF2), vascular endothelial growth factor (VEGF) in blood serum it was carried out by the method of solid-phase Enzyme immunoassay.

Results. The features of the flow of dust lung diseases: the peculiarities of the immunological profile, increasing the level of factors allows to characterize the occurrence, course and progression of dust diseases of the lungs.

Conclusions. Determining the immunological profile allows not only to improve the quality of early diagnosis, but also to optimize strategies for primary and secondary prevention in this pathology, to predict the course of the disease, and to reduce the number of disabling forms.

dusty lung diseases, occupational risk, early diagnosis, immune profile

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