Issues of the effects of lead on circulatory and respiratory diseases
https://doi.org/10.31089/1026-9428-2019-59-12-983-988
Abstract
Introduction. At the present economic stage of development of the industry there is a technological modernization of productions, decrease in operating concentrations of chemical substances in this connection reduction of frequency of occurrence of classical forms of intoxications is observed. Th is applies to the lead, occupying the leading position among industrial and environmental contaminants, which has one of the highest indexes of technological social and environmental significance.
The aim of the study was to assess the impact of metal (lead) as a trigger of various nosological forms of diseases of the circulatory and respiratory organs.
Materials and methods. Clinical and functional, laboratory examinations of 130 persons were carried out: among them 90 employees of the plant for the processing of lead batteries and cables. Th e comparison group included workers who had no contact with lead (40 people), comparable in age and experience.
Results. Analysis of the structure of non-professional diseases of internal organs showed that the leading place is occupied by diseases of the upper and lower respiratory tract (58% and 26%), circulatory organs (40%).
Conclusions. Th e results of the clinical and laboratory examination of workers of the lead batt ery recycling plant indicate the importance of combined exposure to lead as an important risk factor for cardiovascular diseases, pathology of the upper and lower respiratory tract.
About the Authors
N. S. Sorkina
Izmerov Research Institute of Occupational Health
Russian Federation
31, Budennogo Ave., Moscow, Russia, 105275
Russian Federation
31, Budennogo Ave., Moscow, Russia, 105275
L. P. Kuzmina
Izmerov Research Institute of Occupational Health
Russian Federation
Russian Federation
For correspondence: Lyudmila P. Kuzmina, Deputy director on scientifi c work, Dr. of Sci. (Biol.), prof.
31, Budennogo Ave., Moscow, Russia, 105275
L. V. Artemova
Izmerov Research Institute of Occupational Health
Russian Federation
31, Budennogo Ave., Moscow, Russia, 105275
Russian Federation
31, Budennogo Ave., Moscow, Russia, 105275
L. M. Bezrukavnikova
Izmerov Research Institute of Occupational Health
Russian Federation
31, Budennogo Ave., Moscow, Russia, 105275
Russian Federation
31, Budennogo Ave., Moscow, Russia, 105275
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14. Ermolenko A.E. et al. Hygienic and biomedical monitoring at the enterprises of the battery industry (on the example of the Podolsk battery factory). Occupational medicine at the enterprises of Moscow: Sat. scientifi c labor. 1998: 126–31.
15. Hernberg S. Lead poisoning in a historical perspective. American journal of industrial medicine. 2000; 38(3): 244–54.
16. Nawrot T.S., Staessen J.A. Low-level environmental exposure to lead unmasked silent killer. 2006.
17. Silveira E.A. et al. Low-dose chronic lead exposure increases systolic arterial pressure and vascular reactivity of rat aortas. Free Rad. Biol. & Med. 2014; 67: 366–76.
18. Flora G., Gupta D., Tiwari A. Toxicity of lead: A review with recent updates. Interdiscip. Toxicol. 2012; 5: 47–58.
19. Simoes M.R. et al. МАРК pathway activation by chronic lead-exposure increases vascular reactivity through oxidative stress/ cyclooxygenase–2-dependent ways. Toxicology and applied pharmacology. 2015; 283(2):127–138.
20. Lanphear B.P. et al. Low-level lead exposure and mortality in US adults: a population-based cohort study. Th e Lancet Public Health. 2018; 3(4): 177–84
21. Faramawi M.F. et al. Environmental lead exposure is associated with visit-to-visit systolic blood pressure variability in the US adults. International archives of occupational and environmental health. 2015; 88(3): 381–8
22. Lustberg M., Silbergeld E. Blood lead levels and mortality. Archives of internal medicine, 2002; 162(21): 2443–9.
23. Kristal-Boneh E., Coller D., Floom P. at al. Lead exposure and cardiovasculsr disease a systematic review. Am.J. Public Health. 1999; 89(7): 1083–7.
24. Gagatanova T.M. Myocardial bioelectric activity and pumping function of the heart in workers employed in lead production. Gigiyena i san. 1995; 3: 16–9
Review
For citations:
Sorkina N.S., Kuzmina L.P., Artemova L.V., Bezrukavnikova L.M. Issues of the effects of lead on circulatory and respiratory diseases. Russian Journal of Occupational Health and Industrial Ecology. 2019;(12):983-988. (In Russ.) https://doi.org/10.31089/1026-9428-2019-59-12-983-988
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