Importance of selecting informative laboratory biomarkers for the early diagnosis of occupational diseases
https://doi.org/10.31089/1026-9428-2019-1-51-54
Abstract
The authors specified a method to evaluate informativeness of laboratory biomarkers for early diagnosis of occupational factors’ influence on human body: calculation of diagnostic sensitivity, prenosologic importance, pathognomonicity in the case if average laboratory values are within the reference intervals. The method suggested enables considerable decrease errors in calculation of diagnostic characteristics.
About the Author
N. A. Pavlovskaya
Federal Scientifi c Center of Hygiene named aft er F.F. Erisman.
Russian Federation
Russian Federation
Nadezhda A. Pavlovskaya, scientifi c consultant, professor, Dr. Biol. Sci.
2, Semashko str., Mytischi, Moscow region, Russia, 141014.
References
1. Strategy of development of medical science. Th e government of the Russian Federation from December 28. 2012; №2580.
2. Izmerov N.F. Th e global plan of action for the protection of workers ‘ health for 2008–2017 gg: paths and prospects of realization. Med. truda i prom. ekol.2008; 6: 2–8 (in Russian).
3. Resolution XII Russian Congress “Occupation and health” and the all-Russian Congress of Doctor of Occupational Medicine. Moscow. 27–30 November. 2013. Med. truda I prom. ekol. 2014; 1: 5–8 (in Russian).
4. Bossuit P.M.M. Validity Defi nisanie Performansie Klinike validnosti Biomarkera. Journal of Medical Biochemistry.2011; 30: 193–200.
5. De Bord D.G., Burgoon L., Edwards S.W. Systems Biology and Biomarkers of Early Effects for Occupational Exposure Limit Setting. Journal of Occupational and Environmental Hygiene.2015; 12: 41–54.
6. Аltman D.G., Bland G.M., Statistics Notes: Diagnostic Tests 1: Sensitivity and Specifi city. BMG. 1994: 308; 1552–1553.
7. Аltman D.G., Bland G.M., Statistics Notes: Diagnostic Tests 2: Predictive values. DMG. 1994: 309; 102–103.
8. Men’shikov V.V. Th e Proposed guidelines. A strategy to improve the rational use of laboratory tests. Klin. lab. diagnostika. 1996; 5: 49–52 (in Russian).
9. Clinical laboratory diagnostics of occupational diseases. Kir’jakov V.A., Pavlovskaya N.A. Antoshina L.I. etc. Moscow-Yaroslavl. the Chancellor; 2013 (in Russian).
10. Pavlovskaya N. Methodological approaches to selection of informative laboratory biomarkers and their complexes for early detection of the action of harmful factors on the person and the diagnosis of occupational diseases. Klin. lab. diagnostika.2011; 4: 22–5 (in Russian).
11. Men’shikov V.V. Th e Clinical patient safety and the reliability of laboratory information. Klin. lab. diagnostika.2013. 6: 29–36 (in Russian).
12. Antoshina L.I., Pavlovskaya N.A. Jacyna I.V. Informative laboratory biomarkers in the eff ect of vibration on the human body. Klin. lab. diagnostika.2015; 1: 19–22. (in Russian).
13. Lapko I.V. Тhe Condition of neurohumoral regulation in vibration pathology. Zdravoohranenie Rossijskoj Federacii. 2013; 5: 41–3 (in Russian).
Review
For citations:
Pavlovskaya N.A. Importance of selecting informative laboratory biomarkers for the early diagnosis of occupational diseases. Russian Journal of Occupational Health and Industrial Ecology. 2019;(1):51-54. (In Russ.) https://doi.org/10.31089/1026-9428-2019-1-51-54
Views:
606
Email this article 
